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  George Spellwin's ELITE FITNESS Discussion Boards
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  Testosterone is not testosterone

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Author Topic:   Testosterone is not testosterone
Milk_Man
Amateur Bodybuilder
(Total posts: 61)
posted May 20, 2000 11:40 AM     Click Here to See the Profile for Milk_Man   Click Here to Email Milk_Man     Edit/Delete Message
I've seen alot of people claim that Mexican gear is underdosed, is dosed right, don't work, works, and compare it with European steroids. So whats the big difference between a bottle of T200 tested at 196mg/ml and lets say 200mg of testosterone enanthate by ICN(european)?

The difference is that some people see no results except bloat, hair loss, and zits from the fully doesed T200 while others make excelent gains on the ICN at half the doseage with very little side effects.

Why? Because of something called STEREOCHEMISTRY.

Stereochemistry refers to chemisty in three dimensions. Two testosterone molecules can have the same exact number of atoms that are connected in the same order in two dimensions(like if you draw it on paper) BUT may differ because the arrangement of their atoms in space(3d) is different.

So what does that mean? It means that most Mexican testosterone is not identical to human testosterone, and even the slightest difference will prevent that Mexican testosterone from acting the way it should inside a human body. Your gear can be fully doesed but there is no way of knowing the stereochemistry of the molecule. On the other side, European gear is produced with better methods and does resemble human testosterone so you see the results you should.

You heard it here first. PS, some people will respond better to Mexican steroids than others because everyone is different so its not the end of the world if you only have mex connections.

[This message has been edited by Milk_Man (edited May 20, 2000).]

[This message has been edited by Milk_Man (edited May 20, 2000).]

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lexicon
Pro Bodybuilder
(Total posts: 167)
posted May 20, 2000 11:53 AM     Click Here to See the Profile for lexicon     Edit/Delete Message
I totally agree with you. I definately believe quality is by far the most important thing. I personally stay away from products like T200 and NOR200 for these same reasons. I think your much better off spending a little bit more as the quality is much better.

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2Thick
Pro Bodybuilder
(Total posts: 2135)
posted May 20, 2000 12:42 PM     Click Here to See the Profile for 2Thick   Click Here to Email 2Thick     Edit/Delete Message
Finally, somebody has made use of organic chemistry...besides myself.

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Check out my Injection and Syringe Info Site= Injection and Syringe Info Site

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big_guy1
Pro Bodybuilder
(Total posts: 772)
posted May 20, 2000 12:47 PM     Click Here to See the Profile for big_guy1   Click Here to Email big_guy1     Edit/Delete Message UIN: 5126477
nice post bro..good info..thanks

big-guy

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happymf'er
Amateur Bodybuilder
(Total posts: 63)
posted May 20, 2000 01:08 PM     Click Here to See the Profile for happymf'er   Click Here to Email happymf'er     Edit/Delete Message
Good info bro.

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cockdezl
Amateur Bodybuilder
(Total posts: 69)
posted May 20, 2000 05:34 PM     Click Here to See the Profile for cockdezl     Edit/Delete Message
Milk, please show references showing that stereoisomers of test are ineffective androgens. All the positions on testosterone are filled except for the 17 carbon, which allows for an alpha and beta isomer.

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macrophage69alpha
Moderator
(Total posts: 1423)
posted May 20, 2000 05:57 PM     Click Here to See the Profile for macrophage69alpha   Click Here to Email macrophage69alpha     Edit/Delete Message
Milk Man
"It means that most Mexican testosterone is not identical to human testosterone, and even the slightest difference will prevent that Mexican testosterone from acting the way it should inside a human body. Your gear can be fully doesed but there is no way of knowing the stereochemistry of the molecule. On the other side, European gear is produced with better methods and does resemble human testosterone so you see the results you should."

ON WHAT EVIDENCE DO YOU BASE YOUR EVALUATION OF TESTOSTERONE PRODUCED IN MEXICO?

ON WHAT EVIDENCE DO YOU BASE YOU EVALUATION ON THE EFFECTS OF STEREOISOMER BINDING AND AR ACTIVATION?

TESTOSTERONE IS TESTOSTERONE THERE IS NO VARIANCE BETWEEN TESTOSTERONE PRODUCED FOR USE IN ANIMALS V. THAT FOR USE IN HUMANS, IT IS THE SAME- YES THERE IS THE POTENTIAL FOR DIFFERING ISOMERS-
I WOULD HOWEVER LIKE TO KNOW HOW YOU KNOW THAT

A. HUMANS DO NOT THEMSELVES PRODUCE DIFFERENT ISOMERS OF TESOSTERONE?

B. THAT DIFFERING ISOMERS EFFECTS THE ACTIVITY OF THE MOLECULE?

C. THAT THE PRODUCTION METHODS IN EUROPE HAVE ANY EFFECT ON THE PERCENTAGES OF DIFFERENT ISOMERS PRODUCED IN THE SYNTHESIS OF TESOSTERONE?

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MP

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Anabolicum Mister
Pro Bodybuilder
(Total posts: 153)
posted May 20, 2000 06:16 PM     Click Here to See the Profile for Anabolicum Mister   Click Here to Email Anabolicum Mister     Edit/Delete Message
I am by no means a chemist, but I would think that there must only be a finite number of stereoisomers for the molecule. How many are there for testosterone? WHY do european manufacturing methods make more of one isomer than another? Need more info.

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Milk_Man
Amateur Bodybuilder
(Total posts: 61)
posted May 20, 2000 06:39 PM     Click Here to See the Profile for Milk_Man   Click Here to Email Milk_Man     Edit/Delete Message
EVIDENCE? Do you have any evidence to prove me wrong. I doubt it. I do not have any documentation on the process that lets say brovel or tornel uses to synth testosterone. Neither does anyone else. What I do have is real world results that demonstrate what I have said. You can't beat something like that no matter how many medline abstracts you throw out. Let me say it again, REAL WORLD RESULTS is what works not some bs abstract.
Macro, you know that neither you nor anyone else can fully answer those questions without funding a team of lab workers and doing a study that has not been done as of yet, so why ask? The best answer I can give you is all the evidence that I have witnessed in myself and others points to this. Now to the other guy, I'm no organic chemist, I'm a computer/electrical engineer, but I have had some organic chem background and it looks from here that testosterone has more than 2 variations. Lets not forget about the chemicals and procedures that will also effect its shape and structure that are used in the synth.

[This message has been edited by Milk_Man (edited May 20, 2000).]

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macrophage69alpha
Moderator
(Total posts: 1423)
posted May 20, 2000 07:17 PM     Click Here to See the Profile for macrophage69alpha   Click Here to Email macrophage69alpha     Edit/Delete Message
My response to this is that I have seen the real world results- Everyone I know uses mexican gear [they sometimes use European but always go back to mexican(costs less for same results+ easier to get)], and they get good results. My "twin" has used both european and mexican enanthate- found there to be no difference. Twin has used european, asian, middle eastern and mexican Sustanon- no difference.
I will have to say that I find your argument to be interesting, however you have no scientific data to back it up-at all. Your anecdotal evidence conflicts with what I have found. I feel that the main problem with mexican produced gear is related to potency-mg/ml and the underdosig which frequently occured. However, I will add that quality control seems to have improved because of both increased demand and increased competition both from overseas and domestically- especially from the austrailians.

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MP

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Milk_Man
Amateur Bodybuilder
(Total posts: 61)
posted May 20, 2000 07:31 PM     Click Here to See the Profile for Milk_Man   Click Here to Email Milk_Man     Edit/Delete Message
Thats funny because I and most of the people I know have had very poor results from mexican gear vs. european. Now of course we are only talking about testosterone esters. I myself can take 2g of T200/week and gain only water, while a high quality ICN product does me very well. One more thing, I count 6 stereogenic centers on a proper test molecule, that 64 different possible variations. And thats only even if the molecule was synthed properly. Another thing macro, you only gave me your results to back you up against my result "that you have no scientific data to back it up"-in your own words. Sounds like you are doing the same thing I am but claiming your argument over mine.

[This message has been edited by Milk_Man (edited May 20, 2000).]

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macrophage69alpha
Moderator
(Total posts: 1423)
posted May 20, 2000 07:53 PM     Click Here to See the Profile for macrophage69alpha   Click Here to Email macrophage69alpha     Edit/Delete Message
I WAS REFERRING TO YOUR THEORY THAT ISOMERS HAVE DIFFERENT BINDING OR AR ACTIVIATION/TRANSCRIPTION CAPABILITIES- WHICH THEY MUST HAVE IN ORDER FOR YOUR THEORY TO HAVE MERIT.

ORGANIC CHEMISTRY IS NOT MY FIELD OF SPECIALTY, HOWEVER I AM PRETTY SURE THAT JUST BECAUSE AN ISOMER IS POSSIBLE TO CREATE ON PAPER/COMPUTER DOES NOT MEAN THAT IT CAN EXIST IN NATURE. BUT THEN AGAIN O-CHEM IS NOT MY SPECIALTY.

AS TO THE ANECDOTAL RESULTS- ARE YOU CLOSE TO MEXICO? BECAUSE THE FURTHER AWAY YOU GET THE MORE LIKELY TO BE FAKES. DUE TO MY LOCATION- I KNOW, SEE AND TALK TO LOTS OF PEOPLE WHO USE GEAR BOTH MEXICAN AND EUROPEAN- AS WELL AS QUITE A BIT OF ASIAN AND AUSTRALIAN PRODUCTS RECENTLY. I AM NOT QUESTIONING YOUR OBSERVATIONS, MERELY TRYING TO SAY THAT MY OBSERVATIONS HAVE BEEN DIFFERENT.

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MP

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TEXASAMM
Pro Bodybuilder
(Total posts: 146)
posted May 20, 2000 08:02 PM     Click Here to See the Profile for TEXASAMM   Click Here to Email TEXASAMM     Edit/Delete Message
i will have to say that i have done plenty of gas,and i dont grow off tornel or brovel either.There was a time when i was youngerthat i worked at a vet clinic in USA and i would steal 1cc of test cyp. a week i couldnt get anymore without it being noticable and i put on weight. there was also a time that i took 1700mgs. of tornel and brovel gear a week and only got bloated and acne.no muscle increase at all just my 2 cents

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macrophage69alpha
Moderator
(Total posts: 1423)
posted May 20, 2000 08:12 PM     Click Here to See the Profile for macrophage69alpha   Click Here to Email macrophage69alpha     Edit/Delete Message
Milk Man
here is little info, which supports both you and cockdezl

. Although many stereoisomers of this nucleus are possible (and may be synthesized), the saturated nuclear structures of most classes of natural steroids are alike, except at the junction of rings A and B. Simplified three-dimensional diagrams may be used to illustrate stereochemical details. For example, androstane, common to a number of natural and synthetic steroids, exists in two forms (2 and 3), in which the A/B ring fusions are called cis and trans, respectively.

However, other stereoisomers are possible.


Texsamm
are you sure it was not fake?
have you taken other enanthate esters and not gotten results?
just curious


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MP

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bignate73
Pro Bodybuilder
(Total posts: 592)
posted May 20, 2000 09:03 PM     Click Here to See the Profile for bignate73   Click Here to Email bignate73     Edit/Delete Message UIN: 65081685
oh dammit.
now i have to take this into consideration too??? damn.
well ill bump this for some more insight here. good topic. hehe.

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got big?
Amateur Bodybuilder
(Total posts: 50)
posted May 20, 2000 09:38 PM     Click Here to See the Profile for got big?   Click Here to Email got big?     Edit/Delete Message
ah fuck it, even if all I get is acne from this T200 at least i'll have fun popping em, i'm not about to throw this shit in the garbage!

[This message has been edited by got big? (edited May 20, 2000).]

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Brutis
Amateur Bodybuilder
(Total posts: 31)
posted May 20, 2000 10:13 PM     Click Here to See the Profile for Brutis   Click Here to Email Brutis     Edit/Delete Message
Is it just me, or did all this techno-mumble jumble go ever everyone else's head too?

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Slim Whitman
Pro Bodybuilder
(Total posts: 171)
posted May 20, 2000 10:30 PM     Click Here to See the Profile for Slim Whitman     Edit/Delete Message
It's just a fact of science and medicine that some products, whether they are the same or minutely different, respond better in some than they do in others. Choose your poison accordingly.

Slim

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PhatPat
Amateur Bodybuilder
(Total posts: 84)
posted May 20, 2000 10:48 PM     Click Here to See the Profile for PhatPat   Click Here to Email PhatPat     Edit/Delete Message UIN: 56498003
I agree Slim. That makes a bunch of sense. It is kinda like how some medicine works for some, but not for others. Maybe, TEXASAMM, you just didnt respond well to the Mexican product, but did to the European. But I would have to say that from what I have heard and seen, Brovel and Tornel(especially Brovel) products have some impurities because of the environment in which they are produced. Good Topic, Bump.

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TEXASAMM
Pro Bodybuilder
(Total posts: 146)
posted May 21, 2000 12:22 AM     Click Here to See the Profile for TEXASAMM   Click Here to Email TEXASAMM     Edit/Delete Message
there is always the possibility of fake products but this has happened more than once that little vet clinic on Indepedencia in TJ that has shelves of t200 t-50 refovit and decas is one place i used to shop very very cheap prices and Matamorros on the Texas border and we are talking a few years back. I have learned mylesson i dont buy tornel or brovel anymore....SAMM

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cockdezl
Amateur Bodybuilder
(Total posts: 69)
posted May 21, 2000 12:55 AM     Click Here to See the Profile for cockdezl     Edit/Delete Message
I am not of this belief that Mexican steroids are isomerically different for two reasons:

1. The process for the synthesis of testosterone is archaic. To screw it up would be doubtful for a company that specializes in it's manufacture. This is essentially on par with screwing up the synthesis of aspirin.

2. The more likely scenario is underdosing. Why not sell products that contain little or none of the active ingredients claimed? You make all profit since essentially you now have very little costs.

"What I do have is real world results that demonstrate what I have said. You can't beat something like that no matter how many medline abstracts you throw out. Let me say it again, REAL WORLD RESULTS is what works not some bs abstract."

Milk, your rationale that real world evidence is sufficient to support your theory is false, since there are many variable theories to make for your observations. Your theory may be valid, but you are simply denying more plausable theories. Also, those BS abstracts are what allowed for man to learn to synthesize your beloved steroidal compounds to begin with.

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Milk_Man
Amateur Bodybuilder
(Total posts: 61)
posted May 21, 2000 07:55 AM     Click Here to See the Profile for Milk_Man   Click Here to Email Milk_Man     Edit/Delete Message
Cockdezl, do you have a chemical background? Would you consider posting the method that Brovel/Tornel uses to synth testosterone? What is "archaic"? Sounds like achiral.

So you are saying that in the synth process of testosterone only achiral compounds are used? If so you should know that every step of that synthisis can produce a racemic mixture-I don't know if it does or not personally but if you could explain it to me that would be great.

For all I know the end result is 10% human testosterone and 90% garbage. Thats how I explain no results from a 196mg/ml tested T200 product that produced NO (good)RESULTS and a high qualitly European product that does produce muscle gain, keeping everything else relativly constant.

Do you have a better theory for that? Now you can hide in your medline abstracts that contradict themselfs but I think I will stick to the real world.

[This message has been edited by Milk_Man (edited May 21, 2000).]

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coolhandluke
Pro Bodybuilder
(Total posts: 644)
posted May 21, 2000 11:33 AM     Click Here to See the Profile for coolhandluke   Click Here to Email coolhandluke     Edit/Delete Message UIN: 47436318
mex gear= crap
euro gear= good!

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mokhtarsayed
Amateur Bodybuilder
(Total posts: 1)
posted May 21, 2000 12:03 PM     Click Here to See the Profile for mokhtarsayed   Click Here to Email mokhtarsayed     Edit/Delete Message
I don't really know about if mexican gear is bad, but let me tell you a fact that it doesn't really cost too much for a company to manufacture steroids. If the use of steroids is legal in a given country, the manufacturer will have no problem obtaining the raw material from the original supplier (e.g. Organon or Schering), and this would remove any doubt of an inactive stereo isomer. Also, the local manufacturer would be able to produce a large quantity of the drug i.e. no governmental limitations, so the unit price would go down. As long as the active ingredient is original, the rest of the manufacturing process is standard. I have personal experience with Egyptian anabolics, and they were just as effective and ALOT cheaper.

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cockdezl
Amateur Bodybuilder
(Total posts: 69)
posted May 21, 2000 12:32 PM     Click Here to See the Profile for cockdezl     Edit/Delete Message
Milk, I have only minor in Chemistry, so I am not as up to speed on this subject as I wish to be. BUT, I am using the information that I know and several other tidbits of information to help create my argument.

First, from the Encyclopedia of Chemical Technology (3rd Edition, vol. 12), there is a huge chapter on the synthesis of all the various steroids (sex hormones and adrenal), which gives the various syntheses of the androgens. It states that "The two most important routes to testosterone use diosgenin or androstenedione." Then it states that "All of the above procedures give excellent yields of testosterone."

Second, looking in Merck for stereoisomers of testosterone, I do not find any mentioned. Testosterone is called 17B-hydroxy-4-androsten-3-one, thus I can assume that there can be a 17a-stereoisomer, but none is listed. Looking at estradiol, I do find a 17a and B listed.

Finally, you state:
"For all I know the end result is 10% human testosterone and 90% garbage. Thats how I explain no results from a 196mg/ml tested T200 product that produced NO (good)RESULTS and a high qualitly European product that does produce muscle gain, keeping everything else relativly constant."

I must ask, how was this product tested and by whom. The actual contents of the two vials are what I believe to be the most variable factors in this picture.

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Anabolicum Mister
Pro Bodybuilder
(Total posts: 153)
posted May 21, 2000 12:36 PM     Click Here to See the Profile for Anabolicum Mister   Click Here to Email Anabolicum Mister     Edit/Delete Message
MM,

You could be right that mexican test products are inferior to european. You could also be right that this is due to the different isomers of the testosterone molecule. However, the "real world" results that you and others have seen do not prove your theory (while it may support the hypothesis it does not prove it). However, right or wrong, it is an interesting theory and a good post.

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