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  Post cycle clomid thearpy no worries w\ estrogen?

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Author Topic:   Post cycle clomid thearpy no worries w\ estrogen?
biggredd31

Amateur Bodybuilder

Posts: 59
From:
Registered: Apr 2000

posted April 25, 2001 09:13 PM

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are the natural test levels up enough after the 100mg ed 1st week after and 50 mg a week 2nd week after cycle to not worry about estrogen levels?


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Stew Meat

Elite Bodybuilder

Posts: 1097
From:Louisiana
Registered: Jul 2000

posted April 25, 2001 10:33 PM

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Estrogen will be worse post cycle and clomid will do nothing to block estrogen receptors in any tissue other than the hypothalamus: clomid will not prevent gyno or other symptoms of excess estrogen. Make sure you use proviron or armidex while coming off of a cycle.

-Stew


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biggredd31

Amateur Bodybuilder

Posts: 59
From:
Registered: Apr 2000

posted April 26, 2001 01:15 AM

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I have not seen any cycle usages post cycle for proviron and nolvadex. how much and how long after my last shot should i be taking them?


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Weam

Amateur Bodybuilder

Posts: 152
From:Santa Barbara, CA, USA
Registered: Apr 2001

posted April 26, 2001 01:33 AM

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Clomid will block Estrogen receptors, it will combines with estrogen receptors, thus decreasing the number of available receptor sites. Through negative feedback, the hypothalamus and pituitary are thus stimulated to increase secretion of LH and FSH
it can't works without block estrogen receptors, LH & FSH can't be increased without this process

reference :
Fitzgerald, K.R., Shepard, M.D., Young, P.C.M., Stamich, B.M., and Yager, K.L. "Time-Dose Related Effects of Clomiphene Citrate on Estrogen Receptors in the Rat Uterus Utilizing Whole Cell Technique" In Press.


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Weam

Amateur Bodybuilder

Posts: 152
From:Santa Barbara, CA, USA
Registered: Apr 2001

posted April 26, 2001 01:36 AM

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Proviron should not be used after the cycle, it will do nothing for keeping Estrogen low when you're not using Anabolic Steroids, it will just prevent Steroids from aromatising & will not decrease Estrogen level by it self, and especially while Testosterone level after any cycle is low, then there is a very little chances for aromatising, just Estrogen level will be increased due to the inhibition of some hormones as Testosterone, but when Estrogen level increased it might bind to Estrogen receptors therefor either Clomid or Nolvadex is very important after every cycle for many reasons


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biggredd31

Amateur Bodybuilder

Posts: 59
From:
Registered: Apr 2000

posted April 26, 2001 01:48 AM

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muchas gracias bro


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JayisCrazy

Pro Bodybuilder

Posts: 347
From:An Igloo somewhere in Canada
Registered: Jul 2000

posted April 26, 2001 09:26 AM

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Don't even worry about it unless you feel the gyno coming on. Use the clomid post cycle, but not for estrogen blockage! If you need to use Nolva's or Armidex for gyno symptoms.
Cheers,
Jay


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Maxx Out

Amateur Bodybuilder

Posts: 179
From:
Registered: Feb 2001

posted April 26, 2001 09:39 AM

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Clomid will block estrogen sides and also bring your own test production back to normal! Mg for mg it's not as good nolv. but it works and works well!

------------------

Maxx >>>>>


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biggredd31

Amateur Bodybuilder

Posts: 59
From:
Registered: Apr 2000

posted April 26, 2001 12:23 PM

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Thanks for the replies! I made a post a few days ago and got nottin. I was starting to feel like a red-headed step child. (I do have red hair when it is not bleached)


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Spunky

Freak

Posts: 2281
From:USA
Registered: Jun 2000

posted April 26, 2001 12:28 PM

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The way I understood it, clomid does work as an anti-estrogen and isn't as effective as Nolvadex but will help some.. but thats just my opinion, so take it with a grain of salt. Thats just what i've always been told by the "roid-heads" at my gym....


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Stew Meat

Elite Bodybuilder

Posts: 1097
From:Louisiana
Registered: Jul 2000

posted April 26, 2001 04:31 PM

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Clomid will not bind to estrogen receptors outside of the hypothalamus. Clomid was NOT designed as an antiestrogen. It is NOT a drug used to treat breast cancer. Clomid is a fertility drug. It works to produce fertile eggs by selectively binding to estrogen receptors in the hypothalamus. Since it is selective, it allows the production of a fertile egg which. By binding to ER in the hypothalamus, it stimulates the release of LH and FSH. FSH or folicile stimulating hormone, is required for the formation of a mature egg. LH stimulates the overies in females to produce estrogen which allows for the mature egg to become encapsulated. LH in males, stimulates the leydig cells of the testicles to produce testosterone. FSH in males stimulates the visceral cells to produce semen.
Clomid's selective binding affinities are what causes it to differ from Nolvadex which WILL bind to estrogen receptors throguhout the body and would thereby terminate pregnancy and is slightly affective for birthcontrol (since a fertile egg can not be produced if estrogen is blocked).

SECONDLY:
Proviron does not only block estrogen formation while on a cycle. Proviron binds the active sites of aromitase enzymes. This prevents testosterone from aromitising into estrodiol. Taking an antiaromitase while off of a cycle, would have the same effect, in reducing the overall level of estrogen (which is not a good thing) by preventing the conversion of your natural testosterone.

THIRDLY:
Estrogen levels are HIGHER post cycle. This is due to the increased number of aromitase enzymes that were transcripted to accompany the influx of exogenous hormone in an effort for the body to regulate itself. Your body tries to keep a regulated hormonal axis with a 10 to 1 ratio of testosterone to estrogen. With the increase in androgens binding to their AR-mediated reaction sites, there is not only a mRNA signal for the transcription of contractile proteins from myosein, there is also a mRNA signal for the transcription of aromitase enzymes from their respected gene so that the level of homeostasis of 10 to 1 T/E can be reached. Post cycle, when the exogenous hormone levels plumit, there is still a considerable number of antiaromitase enzymes still present in the blood stream. So, whenever the leydig cells of the testicles again begin to produce testosterone, a VERY high percentage of this gets converted to estrodiol. This leaves very low androgen levels and is the time at which people loose most to all of their gains from the cycle (especially if you have an over extened and lenghty cycle).

Proviron 50mg/day; HCG 5000iu/week; Clomid 100/50/25.


-Stew


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