2. oral admin is more stimulatory- a small dose sublingually about 10-15min prior to workout can be very beneficial- much lower doses than topical

3. out partying or want to get really amped up yohimbine can be snorted- though dont over do it- it will make you feel crappy

LETS GET BACK TO TOPICAL AS FAT LOSS IS THE GOAL OF MOST.

A. twice daily topical admin will give you the greatest benefits

B. dosing will vary depending on tolerance, one scoop or 20mg per dosing is a good place to start though some can tolerate/enjoy much higher doses- you will know when you take too much as it will not feel good. (headache, tired, just unwell- nothing really bad just annoying)

C. best sites for application are triceps, "love handles", thighs, glutes, calves- basically any area that has fat accumulation- these areas will vary from individual to individual- though the above listed are the most common.

D. admin with aloe vera gel or aspercreme, it can go in dry but then it is harder to disperse over an area and absorption is not quite as good. FOR optimal absorption, wait 5-10min and then wet hands with warm water and vigourously rub application area again to get the yohimbine that may not have been absorbed.

any other questions E mail me or post and I will try to answer

peace

------------------
"That which does not kill me, will make me stronger."

*** Dont email me asking for a source!!!!! ***

Topical use, however is by far superior for fat loss and keep in mind that yohimbine powder is considerably cheaper than tabs.

peace

------------------

quote:

---

"Don't hate the PLAYER...hate the GAME!"

---

Here's some commentary by Brock Strasser on Dan Duchaine's topical or injectible yohimbine theories and spot reduction. I am starting site injections in a few days, will be interested to see what happens.

I believe that Dan's whole idea of using Yohimbine topically is because he wants to target avascular "white fat cells," meaning that blood flow to them is quite limited and only a little bit of orally dosed Yohimbine will ever make it to these fat cells. Muscles are reddish in color because they contain a large number of big blood vessels, allowing more "stuff" to come and go.

I believe that Dan thinks you've got to either inject a Yohimbine solution directly into the fat with an insulin syringe or spread it out with a transdermal cream or DMSO (this would appear to be an ideal solution, hence Duchaine's Yo-Be-Lean product). My big objection is that the Yohimbine won't exactly stay where you put it when administered transdermally as there are a bunch of blood vessels just under the skin to whisk it away. So it's going to get into the bloodstream and impart a systemic effect anyway (eventually).

Duchaine's response pretty much has been, "Oh, well, at least it's as effective as an oral Yohimbine, plus it hangs around the fat cells for a little while, so it's probably better." I don't really know how much longer the Yohimbine will stay around the fat cells if used in some transdermal mix. If Dan's hypothesis is correct, and it may very well be, then this would probably work quite a bit better than oral Yohimbine. DMSO almost surely is a great transdermal carrier for both compounds.

There are two main hormones, adrenaline, and noradrenaline. They are produced differently in the body. Adrenaline is circulated systematically, while noradrenaline is generated in the nerves of certain cells. Fat cells don't get much blood circulation due to the lack of veins or major arteries. Fat cells only have capilaries. So adrenaline is not mainly used by fat cells, noradrenaline is. Both of these hormones are being produced continuously and used constantly.

There are hormone receptors on cells that are like parking spaces, tailored in size and shape to each type of hormone. The receptors for adrenaline and noradrenaline are called adrenoreceptors. The are everywhere in the body, including fat cells. There are 4 types of these receptors, but we'll concern ourselves with only two, B1 and A2.

Fat cells have both of these receptors. Since fat cells don't get much blood circulation, noradrenaline attaches itself to these receptors.

B1 receptors are good. They activate lipase, the enzyme that breaks down the fat. Lipase causes the fat cell to disassemble itself, breaking down stored triglycerides into fatty acids and glycerol, which get used up for energy. These are our friends, and it is the noradrenaline that makes em work.

A2 are evil. They block lipase in the fat cell. They also encourage the formation of triglycerides in the cell. Also, A2's decreat the generation of noradrenaline a the nerve sites. Of course less noradrenaline means the less effective B1 receptors become. Unfortunately, lower body fat doesn't have many B1's anyway. One more thing, low-calorie diets cause an increase in the number of A2 receptors.

When you go on a low-calorie diet, the following things happen:

1. Fat is lost first and fastest at the
cells with lots of B1 receptors.

2. Very little fat is lost in the cells that have lots of A2 receptors.

3. Noradrenaline levels drop, reducing your body temperature.

4. The number of A2 receptors increase

5. When you give up the diet, even normal eating will cause new fat accumulation in the fat cells that have just increased their number of A2 receptors.

So we need something to block the A2 receptors from accepting the noradrenaline. yohimbe is the answer. It is an A2 antagonist. But here is the bad part, yohimbe is taken oraly and is then transmitted throughout the body via the blood. Now remember that fat cells don't get much blood, so the effects of yohimbe are greatly reduced. You would have to overdose the rest of the receptors in your body just to get enough to your lower fat.

So just taking pills will not produce optimal results. Yohimbe's effect needs to be localized. Direct local injection of yohimbe would work much better.