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  Halflives of common AS...check out this plot

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Author Topic:   Halflives of common AS...check out this plot
Zeke_B

Pro Bodybuilder

Posts: 459
From:
Registered: Jun 2000

posted April 13, 2001 04:58 PM

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I've plotted mg vs time for some common
AS. Hope someone finds this useful. I
normalized everything to a single 100mg
injection. For 250mg, just look up the
mg at a particular time and multiply by 2.5.

http://y42.briefcase.yahoo.com/bc/zekebrules/vwp?.dir=/My+Docum ents&.dnm=halflives.JPG&.src=bc&.view=t&.hires=t

[This message has been edited by Zeke_B (edited April 13, 2001).]


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Zeke_B

Pro Bodybuilder

Posts: 459
From:
Registered: Jun 2000

posted April 13, 2001 05:23 PM

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Does no one find this interesting?


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beefmaster

Pro Bodybuilder

Posts: 349
From:outerspace
Registered: Sep 2000

posted April 13, 2001 05:28 PM

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Thats pretty cool. You could actually reverse the data and come up with detection times as well. Not everyone has a yahoo password to view it though so I bet thats why responses have been low.


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BONZ^

Amateur Bodybuilder

Posts: 235
From:Canada
Registered: Jan 2001

posted April 13, 2001 05:33 PM

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Very nice. Great job bro. The line colors are a bit confusing though.


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40butpumpin

Amateur Bodybuilder

Posts: 230
From:Schenectady, NY USA
Registered: Feb 2001

posted April 13, 2001 05:37 PM

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Bro, how did you do that?


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NYStrip

Amateur Bodybuilder

Posts: 60
From:
Registered: Mar 2001

posted April 13, 2001 05:49 PM

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quote:
Originally posted by beefmaster:
Thats pretty cool. You could actually reverse the data and come up with detection times as well. Not everyone has a yahoo password to view it though so I bet thats why responses have been low.

Do you mean swap x and y? I don't do Yahoo, and I see it ok.


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Riker29

Pro Bodybuilder

Posts: 339
From:San Diego, CA, USA
Registered: Jan 2001

posted April 13, 2001 05:56 PM

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That cannot be correct.

Or at least, not necessarily USEFUL to us the way it is shown.

Why?

Consider this, there is a differnce between something being "in the body:" and it being active.

Sure, the moment , THE MOMENT that you inject TestCyp into your body, its 100% IN THERE. Correct. But is it ACTIVE? No.

It takes a few days or weeks for the more popular Esters to RELEASE the Test so that it is actually moving throughout your body.

So, there are actually 2 things at work here - firsty, how long does it take for the ester to release the substance, then how long does that substance stay active once it has been released.....

I think if you look at that, actually the avalaible amount of Test in your system due to various component, you would see a "bump" sort of graph, starting at zero concentration at time zero ...... rising to a maximum level over time (depending upon how long it took for the ester to release that actual Test into your system. ........ then for the conecntration to lower as the available amount was released and utilized.

Nothing personal to the bro who did the graph.

It look alsmots as if someone took one opf those little "half life" table, and pout that into Exccel, and graphed it ouyt based on a descending slope formula (whatever the std formula is for a half-life numeric progression ....)


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NYStrip

Amateur Bodybuilder

Posts: 60
From:
Registered: Mar 2001

posted April 13, 2001 05:56 PM

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Good work. Brings up an interesting issue. If you run EQ or Primo, and you want to keep a constant amount in the body (re you first sust plot), would the half-life be such that you would take less the following week, then a fractional increase each week thereafter?


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Zeke_B

Pro Bodybuilder

Posts: 459
From:
Registered: Jun 2000

posted April 13, 2001 10:01 PM

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Ok Riker, you have a good point. This is
a simple exponential decay plot. The math
is very simple for a single drug

Q(t) = Qo * exp(r * t)

r is a constant function of the halflife.
I believe it's -ln(2)/halflife. If anyone
is curious I can re-derive it. I left
everything at work.

Here is the way I would use a plot such as
this. Most of the drug that is in the body
at any moment is bound to the ester and
sitting dissolved in oil in the muscle
tissue where it was injected. Since for a
relatively small percentage of the time the
drug is actually in the bloodstream and
doing it's work, I think the rate at which
the drug is leaving the body at any moment
would correlate very nicely to the amount
of the drug entering the bloodstream and
therefore correlate to the steroidal effect
at that moment. In other words, what should
be looked at is the first derivative with
respect to time or the slope of the plot.

This makes sense because as everyone knows,
test with shorter halflives works faster
than test with longer halflives. This is
because it is entering the bloodstream and
being used by muscles at a much faster rate
or in other words the slope is steeper on my
plot.


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liftingnjuicing

Cool Novice

Posts: 11
From:Madison, WI, USA
Registered: Apr 2001

posted April 13, 2001 10:12 PM

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Riker is correct, I know this. Testosterone levels rise up slowly after an ester is injected, peak, and then decline. For example, a regular shot of testosterone enanthate creates peak blood levels around 36 hours post dose.


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Zeke_B

Pro Bodybuilder

Posts: 459
From:
Registered: Jun 2000

posted April 13, 2001 10:28 PM

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I know he's right, I've seen empirically
generated plots of blood testosterone
levels. There's an initial delay because
it takes time for the test to get into the
blood. This causes the bump. Let me
reiterate though, the drug leaves the body
at a rate that is the slope of the plots
I posted. Where is the drug going? Some
of it is entering muscle tissue. How much?
I don't know, but how do you quantify muscle
building effectiveness anyway...the point is
that the rate it is leaving the body for a
given drug probably correlates to the amount
entering the muscles.


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beefmaster

Pro Bodybuilder

Posts: 349
From:outerspace
Registered: Sep 2000

posted April 13, 2001 10:32 PM

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Zeke.....You da man, we'll expect this new plot asap.........LOl


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Riker29

Pro Bodybuilder

Posts: 339
From:San Diego, CA, USA
Registered: Jan 2001

posted April 13, 2001 10:37 PM

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I think actually we would see a resulnat graph, combining these 2 effects:

One effect is that of the ester release - so, this would start at zero, and we would see it rise up to a level of 100% (nominalized of course, saying that at some time in the futute, 100% of the Test which was bound to the ester had in fact been released into the bboody or bloodstreem .... my limited detailed knowledge of biology starting to show when we get into specifcs....)

Then a second effect, which was, of the Test which HAD been released, we would see that this would indded drop off at a constant rate.

This would give us a bump, whose delay from ingestion (how long it takes to get to a usable conentration) and the relative "letngth" of that bump would be determined by the ester involved.

But these graphs which show 100% at day or TIME zero are meaningless for our uses.

Forgives the typos. I am ON now, and my bodyt is shaling a bit from just doing 4 miles of rollerbladinf for some cardio.


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Zeke_B

Pro Bodybuilder

Posts: 459
From:
Registered: Jun 2000

posted April 13, 2001 10:45 PM

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It's okay Riker. I won't bust your balls
for spelling.

I disagree that what I am posting is not
useful. Actually, this is the only point
I am arguing. I, however, totally agree
with you that blood test (or whatever)
levels versus time would be the MOST useful.
I really don't have enough info on the
mechanisms of test entering the blood and
leaving the blood so I could only produce
these plots by faking the constants. All I
have seen are empirical plots with very few
data points. I'll tell you what, I'll do
more research and see what I can find.


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