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 I get so freaking sick of hearing about DOWNREGULATION of receptor cells from gear!
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| Author | Topic: I get so freaking sick of hearing about DOWNREGULATION of receptor cells from gear! | ||
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Elite Bodybuilder 
Posts: 941 |
This was originally posted as an argument with Thegoodandthebad in the "Hello all" thread. Taking steroids will NOT downregulate your androgen receptors. In fact, they will significantly upregulate the AR. Sloan, Jason; Springfield College; The Effects of Testosterone and Insulin-Like Growth Factor-1 on Cultured Human Skeletal Muscle Cells "Androgen receptor was upregulated under all treatment conditions compared to control. Testosterone treatment caused the larges increase in androgen receptor expression. QUANTITY OF RECEPTOR PROTEIN IS AN INDICATION OF THE FUNCTIONAL CAPABILITY OF THE MUSCLE CELL TO RESPOND TO HORMONES WHICH MAY AFFECT MUSCLE HYPERTROPHY. With the addition of testosterone, these systems (the muscles) increased their functional ability to respond to hormonal stimulation by increasing receptor concentration." Here's a little more for you if you are interested in learning about IGF-1: "Combined testosterone and IGF-1 treatment caused a larger increase in IGF-1 receptor protein expression than did either treatment alone... the increased mRNA levels with IGF-1 treatment might be a result of the ability of the IGF-1 system to upregulate gene transcription at a faster rate than the testosterone system."
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Moderator 
Posts: 6067 |
Up this one goes...Keep it at the top...Nice as usual Stew... | ||
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Cool Novice 
Posts: 36 |
At the risk of sounding 'stoopid', let me get this straight. The more you take, the more effective it is? So would this be a reason for longer cycles over the short 3 week on/1-2 week off cycles? I am just trying to figure out how to make the most of this knowledge. | ||
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Moderator
Posts: 6067 |
Thats right TX,the higher the dosage(up to a certain point)and the longer the duration,the greater this effect will be.... | ||
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Elite Bodybuilder
Posts: 941 |
The problem with repeated or long cycles lies in the fact that one can develop a tolerance toward gear just as one can develop a tolerance to any drug. For instance, its been so long since I had a beer, I'd be buzing after one. However, if I drank one or two every day for a week, one may not give me as much of a buz. However, if I drank 12 per day for a week, it may take me 3-4 beers before I got a buz. Tolerance. This must be avoided if you want to gain from your cycles. Tolerance can be avoided by incorporating the time on = time off standard to your cycling. The longer you stay off, the better your anabolic response will be on your next cycle.
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Cool Novice
Posts: 36 |
Damn, in the last few weeks I have been on here, Stew has given me a serious education with all of his informative posts. Thanks, stew! | ||
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Amateur Bodybuilder 
Posts: 247 |
Stew:Hypothetically, can you minimize your receptor downgrade by changing your stack? For example do a 12 week cycle, bridge with primo for only 6 weeks and than continue a second cycle with entirely different gear? Or do the receptor see AS as AS, Test as Test, etc��.. Also what about the older bodybuilder, I�m 50 and have only done two cycles, each one year apart. It seems like anything I take gives me legitimate gains on a low calorie or a high calorie diet. The only major variable in my experience is the intensity of my workout.
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Cool Novice
Posts: 49 |
Stew (or anyone), how do you develop tolerance to an AAS? With alcohol, I recall it's something like your liver cells produce more ribosomes or rough endoplasmic reticulum, so you can synthesize more alcohol dehydrogenase. AAS obviously work through a different pathway, so how does one become tolerant to them? H | ||
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Amateur Bodybuilder
Posts: 229 |
Haywood There are enzymes in the Liver that are responsible for removing excess Testosterone, drugs etc. Now when you first start taking steroids your liver is not prepared for the huge quantities of extra androgens that you throw at it. However the longer you take steroids the more efficient your liver becomes at removing them. This is why the effect of your cycle wears off after X weeks. Not because the receptors are being down regulated. There are some things that can actually block the enzymes in your liver from breaking down drugs. Grapefruit juice and aspirin are two. Was this one of the reasons Munzer took 30 - 40 aspirin per day? You tell me. | ||
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Elite Bodybuilder
Posts: 941 |
quote:
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Elite Bodybuilder
Posts: 1154 |
out of curiosity, is the tolerance drug specific? for instance, if I did a 10 week cycle of deca, and then took a limited time off - 4 weeks, and then did a 10 week cycle of EQ - would the tolerance built up against the deca be applicable to the EQ and/or vice versa on future cycles? I would assume that if I use sust on the first cycle and then cyp on the next it wouldn't really matter b/c test is test and the tolerance towards that is there... this is a great thread, actually a good discussion here for once ------------------ | ||
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Pro Bodybuilder 
Posts: 471 |
They may not downregulate but after a certain time, your body gets used to a certain level of any substance. That is why rest is needed (or a switch to another compound) for continued growth. You may have more receptors int he future, but they don't help you right now. ------------------ Great Information on Injections and Syringes |
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posted April 11, 2001 01:11 AM