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  ARIMIDEX YEAR-ROUND...?

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Author Topic:   ARIMIDEX YEAR-ROUND...?
Jafar

Amateur Bodybuilder

Posts: 50
From:Salt Lake City, UT, USA
Registered: Sep 2000

posted April 04, 2001 12:50 PM

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Something I've been trying to research lately. What if you were to take arimidex year-round? You know, off cycle, all the time, in small doses, like .5mg EOD. Maybe even less.

Is it safe? Would your body develop a tolerence to it?

If it's realistic it seems it would be a decent way to keep your natrual test level slightly elevated and your estrogen level very low while not on cycle.

Am I out of my tree or is this possible?


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Stew Meat

Elite Bodybuilder

Posts: 831
From:Louisiana
Registered: Jul 2000

posted April 04, 2001 01:02 PM

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First off, estrogen is absolutely nessassary in the mail body. It is used in fat metabolism, sleep and mood regulation, mylenization of neurons, influencing dendritic branching (concentration and learning), and hundreds of other processes. To take an antiestrogen year round or whenever it is not needed, comprimises the ability of the system to regulate those processes. It could also have a detremental effect on HPTA.
What would probably happen is that the hypothalamus would be sincing less estrogen than what is being produced. That in mind, there would be an increase in the production of aromatase enzymes in dirrect correlation to the dose that you are taking. Over time, your body would be producing enough aromatase so that it could cope with the inactive aromatase (bound by armidex) in an effort to stabalize itself. If you ever stopped taking the armidex, the body woudl still be producing the same amount of aromatase enzymes and all most all of your testosterone may be converted into estrogen leaving you unable to support muscle mass, extreme cases of female pattern fat distribution, and gyno enough to give you large breasts. You will be tottally reliant on antiestrogens to keep from becoming deformed, depressed, and unactrive. It could take years before your natural hormonal homeostasis could be resumed.


-Stew


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Jafar

Amateur Bodybuilder

Posts: 50
From:Salt Lake City, UT, USA
Registered: Sep 2000

posted April 04, 2001 02:04 PM

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Okay, so it won't work. I guess I thought that the HPTA response would be a positive one, i.e. upping LHRH, in turn raising the testosterone, due to the extremely low estrogen, sort of like the clomid response. I wasn't aware that the hypothalamus could turn up aromatase enzyme production.

Very interesting indeed.

[This message has been edited by Jafar (edited April 04, 2001).]


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'ORCHITIS'

Elite Bodybuilder

Posts: 831
From:Deep within the Ttokkyo Labs
Registered: Sep 2000

posted April 04, 2001 04:54 PM

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That sucks! I guess I shouldn't use it when off-cycle, huh. Do you think that three straight months of use will have this effect? I have been using it to attempt to raise my natural test level while I have been off, so do you think I'm screwed?

------------------
'This is what it's all about'

[This message has been edited by 'ORCHITIS' (edited April 04, 2001).]


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Stew Meat

Elite Bodybuilder

Posts: 831
From:Louisiana
Registered: Jul 2000

posted April 04, 2001 05:03 PM

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You could possible consider yourself a test subject Have you been getting frequent blood work? If so, and you know what your baseline was precycle, you will be able to tell how long it takes for your natural hormone levels to restore. I'm very interested to know how long it takes for your baseline testosterone to return to normal after you stop the armidex...
There has been no studies performed (to my knowlege) about the effects of Armidex overtime. Therefore, all I can do is speculate.


-Stew


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'ORCHITIS'

Elite Bodybuilder

Posts: 831
From:Deep within the Ttokkyo Labs
Registered: Sep 2000

posted April 04, 2001 05:07 PM

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No, I haven't had any bloodwork done in a while. So, if I stop "cold turkey" what do you think will happen? Also, is there anything I could take to help?

------------------
'This is what it's all about'


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Jafar

Amateur Bodybuilder

Posts: 50
From:Salt Lake City, UT, USA
Registered: Sep 2000

posted April 04, 2001 06:57 PM

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What if you switched over to clomid for the time being? I mean, if what Stew says is correct, and you now have excess aromatase enzyme, taking clomid would block the estrogen receptors, let the free estrogen run its course, and you should return to normal.

Or, what about Proviron? It is a mild aromatase inhibitor that from what I understand operates under a different mechanism than arimidex. So, since your body is currently used to countering the effects of arimidex, perhaps a short high dose cycle of proviron could even it out.

Again, all theories. Guess-work.


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apbt549

Amateur Bodybuilder

Posts: 115
From:fl
Registered: Jan 2001

posted April 04, 2001 07:12 PM

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hey since stew did the first off i will do the 2nd off you would be broke then you wouldn't have to worry about it if you took it year around


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'ORCHITIS'

Elite Bodybuilder

Posts: 831
From:Deep within the Ttokkyo Labs
Registered: Sep 2000

posted April 04, 2001 07:49 PM

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Bump

------------------
'This is what it's all about'


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gotmilk

Cool Novice

Posts: 20
From:
Registered: Feb 2001

posted April 04, 2001 08:05 PM

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you must have some serious cash.

don't forget..just EOD..hehhee


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'ORCHITIS'

Elite Bodybuilder

Posts: 831
From:Deep within the Ttokkyo Labs
Registered: Sep 2000

posted April 04, 2001 08:28 PM

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quote:
Originally posted by 'ORCHITIS':
No, I haven't had any bloodwork done in a while. So, if I stop "cold turkey" what do you think will happen? Also, is there anything I could take to help?


Anyone?

------------------
'This is what it's all about'


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40butpumpin

Amateur Bodybuilder

Posts: 215
From:Schenectady, NY USA
Registered: Feb 2001

posted April 04, 2001 09:19 PM

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Stew brought up some excellent points here, thanks for that info Stew I know it helps me a lot.

I don't feel that 3 months will bother you, however, because I actually used it for longer than that at one time and I was taking a 1 mg. tab nearly every day. I stopped about 2 months ago and haven't had any problems. 3 months isn't enough to get you into real trouble, you'll be fine, don't sweat it.


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'ORCHITIS'

Elite Bodybuilder

Posts: 831
From:Deep within the Ttokkyo Labs
Registered: Sep 2000

posted April 04, 2001 10:22 PM

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Thanks bro, that's what I was hoping to hear. I think I will start to taper the dose down a little per day that way I don't shock my body so bad. I appreciate the info.

------------------
'This is what it's all about'


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Stew Meat

Elite Bodybuilder

Posts: 831
From:Louisiana
Registered: Jul 2000

posted April 05, 2001 12:44 AM

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quote:
Originally posted by Jafar:
What if you switched over to clomid for the time being? I mean, if what Stew says is correct, and you now have excess aromatase enzyme, taking clomid would block the estrogen receptors, let the free estrogen run its course, and you should return to normal.

Or, what about Proviron? It is a mild aromatase inhibitor that from what I understand operates under a different mechanism than arimidex. So, since your body is currently used to countering the effects of arimidex, perhaps a short high dose cycle of proviron could even it out.

Again, all theories. Guess-work.


Cloimid works like Nolvadex in that it binds to estrogen receptors and prevents estrogen from doing so. The difference, however, is that clomid is a selective estrogen inhibitor. It binds to the receptors in the hypothalamus and does not bind to receptors throughout the body. This said, it should have almost no effect as an antiestrogen during a cycle. It will however give the appearance of stimulated testicles as they will not shrink, but that is due to FSH stimulating the production of semen. That aside....

Proviron is still an antiaromitase. It will bind to aromatase enzymes in the blood and the body would eventually produce more aromatase in an effort to stabilize itself.


This is all "Stew Theroy" and will be hard to prove wrong, but I can not prove that it is right. But based on logic, I believe that it is true.

-Stew


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DCS

Amateur Bodybuilder

Posts: 292
From:
Registered: Jan 2001

posted April 05, 2001 12:53 AM

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there is no evidence that the body adjusts the amount of aromatase enzymes in response to a low estrogen level. TO say this is pure speculation and probably not true.


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QuadCam

Cool Novice

Posts: 39
From:C-bus, OH
Registered: Feb 2001

posted April 05, 2001 04:04 AM

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I was using Teslac as an anti-aromitase during several weeks of my Sust 500 cycle. I've heard that it can permanently inhibit a males ability to "foster" (I know we can't actually produce it) estrogen. Anyone with any experience?
The dosage was 250mg ED for weeks 2-5.5, I have 10 left which I plan on taking in conjunction with clomid at the start of my 3rd off week. Thanks


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Jafar

Amateur Bodybuilder

Posts: 50
From:Salt Lake City, UT, USA
Registered: Sep 2000

posted April 05, 2001 06:34 AM

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quote:
Originally posted by DCS:
there is no evidence that the body adjusts the amount of aromatase enzymes in response to a low estrogen level. TO say this is pure speculation and probably not true.

That's what I thought too. However, on second thought, if we need some estrogen in our bodiesfor various things, then there must be some mechanism to start converting test into it, right? The only way to do that is with aromatase enzyme.


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