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good (simple) DNP reading.

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Topic: good (simple) DNP reading.

bstrong

Elite Bodybuilder

Posts: 1222
From:
Registered: Jun 2000

posted April 03, 2001 05:08 PM

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i had this book for a year now, and only today (by mistake) red this.

2,4-Dinitrophenol (DNP)

DNP is a chemical uncoupler of electron transport and oxidative phosphorylation.

DNP permeabilizes the inner mitochondrial membrane to protons, destroying the
proton gradient and, in doing so, uncouples the electron transport system from the
oxidative phosphorylation. In this situation, electrons continue to pass through the
electron transport system and reduce oxygen to water, but ATP is not synthesized in
the process. The compound, trifluorocarbonylcyanide phenylhydrazone (FCCP) , is also an uncoupler.

The phenolic group of DNP is usually dissociated at intracellular pH. However, a
DNP molecule that approaches the inner mitochondrial membrane from the outside becomes protonated (because the pH is
lower there). Protonation increases the hydrophobicity of DNP, allowing it to diffuse into the membrane and, by mass action, to
pass through. Once inside, the higher pH of the matric deprotonates the phenolic hydroxyl again. Thus, DNP has the effect of
transporting H+ back into the matrix, bypassing the F0 proton channel and thereby preventing ATP synthesis.

mrhamilton

Cool Novice

Posts: 16
From:
Registered: Mar 2001

posted April 03, 2001 05:36 PM

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damn, that clears everything up now! lol

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bstrong

Elite Bodybuilder

Posts: 1222
From:
Registered: Jun 2000

posted April 03, 2001 05:51 PM

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sorry, my bad, i'm a little tired.
DNP "trickes" the cel to enter it, and once inside lower the ATP proudction.
hopes this clear it up, i think it's a good reading anyway.

SHREADER

Amateur Bodybuilder

Posts: 55
From:THE FUTURE
Registered: Mar 2001

posted April 03, 2001 08:14 PM

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Bstrong what is the name and author of the book. I'D like to read it.

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