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 Anabolic Discussion Board
 Theory on possible benefits of prohormones post-cycle
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| Author | Topic: Theory on possible benefits of prohormones post-cycle | ||
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Amateur Bodybuilder 
Posts: 115 |
I got to thinking about how prohormones, such as andro, might be beneficial when coming off a cycle. I haven't seen any research and would like your opinion on my thoughts. Obviously many feel that under normal conditions, prohormones don't work and one usually ends up with more crappy side-effects (acne, increased estrogen, possible hair loss, etc.)than testosterone increases sufficient to cause muscle hypertrophy. I think this is because prohormones are molecules very similar to testosterone but they are also similar to estrogen and other metabolites of testosterone. Therefore the prohormones have many possible pathways of conversion. Since testosterone is at higher levels when not using AS, then the prohormone is likely to experience a flux toward hormones and other metabolites which are at lower concentrations such as estrogen, DHT, etc., and thus giving the negative side effects. However, the hormonal environment would be the exact opposite when comming off a cycle. Testosterone would be lower, estrogen and other metabolites would be higher, and the prohormone would experience a flux towards conversion to testosterone. The prohormone molecule would not be sufficiently shaped to bind to the hypothalamus and keep endogenous testosterone production supressed by means of the negative-feedback loop. Meanwhile the high concentrations of the prohormone would create a flux towards increased testosterone production instead of other pathways. Thus aiding in keeping gains while the use of clomid helps restore normal functioning. I'm not saying this is correct, just some thoughts. Tell me what you think?
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Amateur Bodybuilder
Posts: 248 |
YOu think to much. | ||
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Amateur Bodybuilder
Posts: 115 |
LOL! | ||
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Freak 
Posts: 2087 |
Not a great idea, I'll tell ya why. Pro-horomones also shut down nat. test, just not to the extent that juice does. So, when coming off a cycle and you are trying to get the nat. test going again by the use of clomid or what have you, it would be more detramental the benificial. Now, the use of tribulas would be good to use. It stimulates the production of LH, as does clomid so the use of them in conjunction, in theory, would be productive, whereas the use of andro and clomid would be counter-productive. | ||
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Amateur Bodybuilder
Posts: 115 |
If it does shut down natural test production, then yes your point is correct. However, I'm not sure it does this. I have heard people say that but haven't seen or heard of any studies showing this to be the case. I would think that the the substrate-receptor complex in the negative feedback loop is quite specific in that only androgens having the required structure and orientation of functional groups to bind and cause HTPA shutdown. Prohormones do not have the same functional group as androgens and would therefore not bind the receptor in that mechanism. Otherwise several molecules in the body similar to testosterone in structure could theoretically cause inhibition as well? I think the receptor would have to be more stereospecific than that. Correct? Also I don't believe that test production can be suppressed to differing extents. Either the pathway is inhibited or it isn't. [This message has been edited by bigtbone (edited March 31, 2001).] [This message has been edited by bigtbone (edited March 31, 2001).] | ||
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Amateur Bodybuilder
Posts: 115 |
I have to bump. Nobody has any opinions or knowlegde that would confirm or dispute this? |
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posted March 31, 2001 07:19 PM