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 Anabolic Discussion Board
 half lives?
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| Author | Topic: half lives? | ||
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Amateur Bodybuilder 
Posts: 184 |
I know everyone on the board uses the half lives of the various A.S. as an indication of how rapidly they "kick in" so to speak. When you refer to half lives(don't worry, i know what a half life is, i've taken chemistry and much math and physics), are you referring to the amount of time that the molecule (ie test. propinate) takes to degrade to half of its initial number of moles, or are you referring to the time it takes the test to break off of the propinate subunit, and be free floating test.? I'd imagine that it cannot break off of the propinate molecule right away, because then you just have free floating test., and there wouldn't be differances in the tests you use(ie test propinate and test cypionate). Someone who knows the chemistry of these drugs, please inform me as to exactly what happens. I haven't taken organic chem. yet (but i am next year).     | ||
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Amateur Bodybuilder
Posts: 184 |
bump for the biochem majors out there... | ||
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Amateur Bodybuilder
Posts: 184 |
dammit, don't no one know shit?!? | ||
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Elite Bodybuilder 
Posts: 1057 |
When we talk about the half-lives of esters, we are usually talking about the half-life of the depot itself. That is to say, we are talking about the length of time it takes for the drug to be released from its injection site into general circulation. | ||
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Amateur Bodybuilder
Posts: 184 |
ok...why would that vary with the differant esters? | ||
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Cool Novice 
Posts: 41 |
It's based on the length of the ester chain. Esters are chains of hydrogen & carbon that have been placed at (generally speaking) the 17th carbon position on the steroid itself. The longer the chain, the longer the ester takes to break down and allow the steroid to do it's job. If I remember correctly, the longer the chain, the less water soluable the steroid becomes and the more fat soluable it becomes. Keeping it in the injection muscle for longer. Releasing the hormone slower as the long ester chain breaks down. I think, anyway... I'm sure there's chemical gurus out there who can explain this better than myself. | ||
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Pro Bodybuilder 
Posts: 304 |
Right-on Jafar. The ester lowers the water solubility which raises the partition coefficient (the ratio between lipid solubility and water solubility). Apparently, it also raises the lipid solubility as well allowing higher drug concentrations in the oil. The gist (I'm no biochemist) is that this partition coefficient correllates to how quickly the drug reacts chemically with the water in the body which replaces the ester with a hydroxy (OH) group restoring it to testosterone. |
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posted March 31, 2001 07:16 PM