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 Anabolic Discussion Board
 RECEPTORS
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| Author | Topic: RECEPTORS | ||
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Elite Bodybuilder 
Posts: 744 |
The reason gear doesn't work the same has NOTHING TO DO WITH YOUR RECEPTORS. If anything, you will get BETTER results after your first cycle in regards to receptor sensitivity to gear. Testosterone INCREASES the numbers of androgen receptors. The problem lies in the liver's ability to metabolise it. Works the same way that you can build up a tolerance to any drug. You can build up a tolerance to gear. The longer you wait post cycle, the less tolerance you will have and the better your results will be. If you still don't see gains as good as your first cycle, well friend, you are experiencing what is known as the placebo effect. Since it was your first cycle, you probably worked out twice as hard. If you had injected canola oil, you would probably have seen awsome gains too. Gear does not work magic. It is all about how hard you bust your ass. Receptors come and go just as the cells of your skin... The idea of "receptor cleaning" is ludacrious. What determines effectivenss of gear aside from how easy it is metabolized (destroyed by the liver) is the NUMBER of receptors. Now, testosterone (and its derivitives supossedly) can have a direct effect on receptor transcription. This has been studied and is well documented. What this means is that while you are taking gear, the number of receptors will increase (upregulate). -Stew     | ||
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Elite Bodybuilder
Posts: 789 |
Damn good post! ------------------ | ||
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Elite Bodybuilder
Posts: 744 |
Bump so people will quit asking this question...
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Pro Bodybuilder 
Posts: 351 |
Is this your "scientific" opinion based on your research and findings, or are you quoting exact research on this topic? The body does down-regulate and up-regulate receptors. This is a fact. I have always thought, so have most others, that this occurred due to an increase in that particular hormone in the blood. Why do you say that it is dependent on liver metabolism? I was not aware that the liver "activated" the hormone, but was only involved in eliminating it. I would like to hear more about this. What you said about taking more time off between cycles makes sense. Time off will increase the effectiveness of the next cycle. But I don't think that it has anything to do with the liver becoming resistant to the effects of the hormone or due to an impaired ability to metabolize it. You are right in saying that the number of hormone receptors is dynamic. They change just like any other tissue. I think that the time off that you are talking about is an opportunity for the body to up-regulate its receptors due to a decrease, or normal blood hormone levels. Regardless of the reason why, I agree with you about taking time off between cycles so that you can optimize your gains. | ||
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Elite Bodybuilder
Posts: 744 |
quote: I was not giving an opinion. I was presenting FACTS.
quote: The body UPREGULATES its receptors when introduced to testosterone. The body DOWNREGULATES its receptors when they are no longer needed. This is a fact.
quote: Correct. The amount of the hormone will cause an increase in receptor site transcription in a dose specific manner.
quote: Because it is scientific fact and not uneducated myth. Just as the world is not flat, the liver will break down (metabolise) exogenous hormone. Maybe you don't understand the definition of "metabolise." The liver does not "activate" hormone. But you are correct in saying that the liver "eliminates" hormone.
quote: Wrong. The liver will metabolise hormone from the time that you first inject it. The liver's efficiency at doint this will improve over time until you have to use higher dossages to compensate. This is what is known as a tolerance and it will diminish when one takes a break from cycling.
quote: Wrong. The body WILL NOT UPREGULATE its receptors when coming off of a cycle. The body will DOWNREGULATE post cycle. The body increases androgen receptor concentration (upregulate0 whenever large amounts of hormone are introduced into the system. Perhaps you have an incorrect definition of "upregulate/downregulate."
[This message has been edited by Stew Meat (edited March 30, 2001).] | ||
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Amateur Bodybuilder 
Posts: 74 |
Some good points there mate, a lot of people seem to find it much more difficult to gain 'naturally' while off the juice, do you think this is 'all in the head' too, this is something ive also been wondering for a while...... Gymbob. | ||
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Elite Bodybuilder
Posts: 744 |
The bigger you are, the harder it is to gain naturally. Well, the harder it is to gain period. Our bodies have a natural resistance to adding additional muscle (myostatin gene). When people reach a certain point, it is very hard to grow and gear is even more helpful. But most people should grow "naturally" while off cycle if they exercise the same ferver that they did while "on."
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Amateur Bodybuilder
Posts: 277 |
Bump, there are olat of real good points beign made here, very educational.... ------------------ |
All times are ET (US) | |
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posted March 30, 2001 01:32 AM
