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  DNP-the governments toxicity opinions-MACRO'S COMMENTS

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Author Topic:   DNP-the governments toxicity opinions-MACRO'S COMMENTS
macrophage69alpha
Moderator
(Total posts: 1115)
posted March 30, 2000 02:02 AM     Click Here to See the Profile for macrophage69alpha   Click Here to Email macrophage69alpha     Edit/Delete Message
you will find my comments in ALL CAPS


What are dinitrophenols?
(Pronounced die ni'tro fe' nolz)

Dinitrophenols are a class of manufactured chemicals that do not occur naturally in the environment. There are six different dinitrophenols.

The most commercially important dinitrophenol, 2,4-dinitrophenol (DNP), is a yellow solid with no smell. It is used in making dyes, wood preservatives, explosives, insect control substances, and other chemicals, and as a photographic developer.

DNP DOES SMELL-VERY STRONG- KIND OF LIKE CHERRY WOOD

It was used in diet pills in the 1930s but was banned for this use in 1938. It may be sold under several trade names, including Caswell No. 392, Sulfo Black B, and Nitro Kleenup. Use of trade names is for identification only and does not imply endorsement by the Agency for Toxic Substances and Disease Registry, the Public Health Service, or the U.S. Department of Health and Human Services.

What happens to dinitrophenols when they enter the environment?

DNP enters the air, water, and soil during its manufacture and use.
It may be formed from reaction of other chemicals in the air.
DNP may also enter the environment through landfill and storage tank leaks, or accidental spills during manufacture or transport.
It dissolves slightly in water, and does not easily evaporate to air.
It can be broken down slowly in water and soil by small organisms or by reacting with other chemicals.
DNP sticks to particles in water, which will cause it to eventually settle to the bottom sediment.
DNP also sticks to some types of soil particles, which may prevent it from moving very deep into the soil with rainwater.
DNP probably does not build up significantly in fish.
How might I be exposed to dinitrophenols?

Breathing contaminated workplace air where it is manufactured or used.
Breathing contaminated air from DNP-containing waste sites, waste incineration, or automobile exhaust.
Touching contaminated soil or water near DNP-containing waste sites.
Ingesting contaminated soil or water near DNP-containing waste sites.

DONT FORGET ENCAPUSLATING AND CONSUMING IT


How can dinitrophenols affect my health?

Most of the information on the health effects of dinitrophenols comes from old studies of patients who were prescribed diet pills containing dinitrophenol before it was banned.

Deaths have occurred in people who ingested 3-46 milligrams of dinitrophenols per kilogram of body weight per day (3-46 mg/kg/day) for short periods, or 1-4 mg/kg/day for long periods. WHILE THIS MAY BE TRUE THEY DIED FROM DEHYDRATION, HYPERTHERMIA, AND STARVATION/EXTREME LOW BLOOD SUGAR, ETC..- ALL OF WHICH CAN BE AVOIDED WITH PROPER NUTRITION, SUPPLEMENTS AND EATING- DONT FORGET THOSE CARBS. Also, people who breathed air containing 40 mg dinitrophenols per cubic meter of air (40 mg/m3) for long periods have died.

The amount of dinitrophenols ingested that causes harmful effects varies among people. Increased basal metabolic rate (the rate that you use energy at complete rest)- MAKES YOU LOSE FAT, increased sweating- DEHYDRATES YOU- WHY YOU TAKE GLYCEROL AND 2 GALLONS OF WATER MIN., a feeling of warmth, weight loss-WHY MOST PEOPLE TAKE IT, and increased heart rate-THIS IS NOT TRUE-EXCEPT IN CASES WHERE LOW BLOOD SUGAR RESULTS IN THE RELEASE OF GLUCAGON,ETC.., breathing rate-INCREASED RESPIRATION IS A NORMAL FUNCTION OF INCREASED METABOLISM, and body temperature have been observed in people who swallowed as little as 1 mg/kg/day or as much as 46 mg/kg/day for short or long periods of time.

Ingesting 2-4 mg/kg/day DNP for short or long periods has caused cataracts in some people-ONE PERSON-THEY HAVE ONE ANECDOTAL CASE- WHICH REMARKABLY, WHEN COMPARED TO THE DNP INGESTING POPULATION, IS THE SAME AS AMONG THE GENERAL POPULATION-STILL WE TAKE EXTRA ANTIOXIDENTS- JUST IN CASE, while ingesting 1-4 mg/kg/day for short or long periods has caused skin rashes and decreases in white blood cells.-I HAVE SEEN NO RESEARCH THAT POINTS THIS OUT BUT SKIN RASHES WERE PROBABLY DUE TO LESS FATTY ACIDS FOR SKIN MAINTANANCE AND SOME ALLERGIC REACTIONS

How likely are dinitrophenols to cause cancer?

The Department of Health and Human Services (DHHS), the International Agency for Research on Cancer (IARC), and the EPA have not classified dinitrophenols for carcinogenicity. FOR GOOD REASON DNP HAS BEEN SHOWN TO NOT BE CARCINOGENIC

There are no studies available in people or animals on the carcinogenic effects of dinitrophenols.
WELL AREN'T WE LITTLE LIARS- THERE HAVE BEEN CANCER STUDIES IN ANIMALS 6 MONTHS AT HIGH EXPOSURE LEVELS IN MICE- NO CARCINOMAS

Is there a medical test to show whether I've been exposed to dinitrophenols?

Tests are available that measure the amount of DNPs or their breakdown products in blood, urine, and samples of tissue from the body. However, these tests may require special equipment and may not be available in your doctor's office.

Has the federal government made recommendations to protect human health?

The EPA recommends that not more than 70 parts of dinitrophenols per billion parts of water (70 ppb) be present in lakes or streams used for swimming.

The EPA lists DNPs as hazardous air pollutants (HAP) under the Clean Air Act. The EPA also requires that discharges or spills into the environment of 10 pounds or more be reported.

SOME EXTRA POINTS DNP IS ANTI PROTEOLYTIC- MUSCLE SPARING-

DNP IS STILL DANGEROUS IF TAKEN INCORRECTLY AND/OR WITHOUT THE PROPER PREPARATIONS. ITS USE IS NOT AN UNDERTAKING THAT SHOULD BE ENTERED INTO WITHOUT CONSIDERABLE KNOWLEDGE AND RESEARCH- KNOWLEDGE IS POWER.

BTW- DNP IS NOT FOR PREGNANT WOMEN- DNP IS A TERATOGEN- YOU SHOULD ALSO NOT TAKE IT AND HAVE SEX WITH YOUR PREGNANT WIFE OR GIRLFRIEND- EVEN SLEEPING IN THE SAME BED COULD BE HARMFUL BECAUSE YOU BREATH AND SWEAT OUT DNP ALL THE TIME- SO BASICALLY DONT TAKE IT IF YOUR SIGNIFIGANT OTHER IS PREGNANT

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MP

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WCP
Pro Bodybuilder
(Total posts: 520)
posted March 30, 2000 02:10 AM     Click Here to See the Profile for WCP   Click Here to Email WCP     Edit/Delete Message UIN: 39184064
Kick ass stuff Macro..
I have one question..it does mention some effects on animal..but lets say you have a 130lb Rotty that just has to take up half the bed. Would sweating DNP, and exhaling it be detrimental to the health of the animal? Or what about handling infants or small children?
Good Stuff,
WCP

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champion
Pro Bodybuilder
(Total posts: 111)
posted March 30, 2000 02:13 AM     Click Here to See the Profile for champion   Click Here to Email champion     Edit/Delete Message
Interesting. worth the read. thanks mac

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Suffering is virtue. Progress is pain.
Anything less than a stoic lust for this philosophy will leave you short of your ultimate potential.

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bignate73
Pro Bodybuilder
(Total posts: 242)
posted March 30, 2000 02:54 AM     Click Here to See the Profile for bignate73   Click Here to Email bignate73     Edit/Delete Message UIN: 65081685
it would be cool to be around little kids and the like. A teratogen is something that would effect an unborn child's development. marijuana being another teratogen.
thats pretty good info macro. it never ceases to amaze me how you find all this info. geez, some people just have their finger on the pulse...lol. peace!

oh yeah i found old junior high photos too....lol.

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lift eat grow!!!

[This message has been edited by bignate73 (edited March 30, 2000).]

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Painkiller
Amateur Bodybuilder
(Total posts: 94)
posted March 30, 2000 08:06 AM     Click Here to See the Profile for Painkiller   Click Here to Email Painkiller     Edit/Delete Message
good post......bump!

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ozzymandius
Pro Bodybuilder
(Total posts: 173)
posted March 30, 2000 04:28 PM     Click Here to See the Profile for ozzymandius   Click Here to Email ozzymandius     Edit/Delete Message
Great Post Worth reading more then once. I'll bimpity BUMP it.

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gamer
Amateur Bodybuilder
(Total posts: 67)
posted March 30, 2000 04:31 PM     Click Here to See the Profile for gamer   Click Here to Email gamer     Edit/Delete Message
Good post on a contraversial topic ...as usual.
bumppppp.

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macrophage69alpha
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(Total posts: 1115)
posted March 30, 2000 06:14 PM     Click Here to See the Profile for macrophage69alpha   Click Here to Email macrophage69alpha     Edit/Delete Message
bump- hear the governments side- with appropriate comments and corrections by yours truly

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MP

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giantset
Amateur Bodybuilder
(Total posts: 98)
posted March 30, 2000 07:10 PM     Click Here to See the Profile for giantset   Click Here to Email giantset     Edit/Delete Message
Hey macro,

I've noticed that weight loss decreases with successive cycles of DNP. I done 4 cycles in a row, 6-7days on and 4-6 days off, and on the 4th cycle it seems that I only lost about 2-3 pounds but on the first one I lost more like 5-7. Could this be due to falling t3 levels resulting from repetitive dieting or is the post cycle carb loading possibly putting some fat back on?

Later,
giantset

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macrophage69alpha
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(Total posts: 1115)
posted March 30, 2000 07:30 PM     Click Here to See the Profile for macrophage69alpha   Click Here to Email macrophage69alpha     Edit/Delete Message
that is not enough time off
depending on the dosage you may not ever go off- becuase of DNP insulin blunting effect you are probably not getting good glycogen uptake during your carb up phase- take at least 2 weeks in between cycles

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MP

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Doc Ponch
Amateur Bodybuilder
(Total posts: 27)
posted March 31, 2000 09:52 PM     Click Here to See the Profile for Doc Ponch   Click Here to Email Doc Ponch     Edit/Delete Message
Good post, Mac. Thanks.

The Doctor

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macrophage69alpha
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(Total posts: 1115)
posted April 02, 2000 09:56 PM     Click Here to See the Profile for macrophage69alpha   Click Here to Email macrophage69alpha     Edit/Delete Message
bump

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MP

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D-Town
Pro Bodybuilder
(Total posts: 164)
posted April 02, 2000 10:19 PM     Click Here to See the Profile for D-Town   Click Here to Email D-Town     Edit/Delete Message
Macro, would DNP adversely affect some one with low blood sugar?

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macrophage69alpha
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(Total posts: 1115)
posted April 02, 2000 10:35 PM     Click Here to See the Profile for macrophage69alpha   Click Here to Email macrophage69alpha     Edit/Delete Message
depends on why they had low blood sugar

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MP

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A-mass
Pro Bodybuilder
(Total posts: 382)
posted April 02, 2000 10:45 PM     Click Here to See the Profile for A-mass     Edit/Delete Message
bump it. nice work Macro.

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the alpha male


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D-Town
Pro Bodybuilder
(Total posts: 164)
posted April 03, 2000 12:01 AM     Click Here to See the Profile for D-Town   Click Here to Email D-Town     Edit/Delete Message
Macro, How bout Hypoglycemia? Would A.S. affect this as well since they affect the glucose level.

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macrophage69alpha
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(Total posts: 1115)
posted April 03, 2000 12:19 AM     Click Here to See the Profile for macrophage69alpha   Click Here to Email macrophage69alpha     Edit/Delete Message
hypoglycemia=low blood sugar
you need to be more specific as to the cause-insulin hypersensitive, over produce insulin, intermittant glucagon release etc etc etc.

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MP

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D-Town
Pro Bodybuilder
(Total posts: 164)
posted April 03, 2000 12:31 AM     Click Here to See the Profile for D-Town   Click Here to Email D-Town     Edit/Delete Message
So all of the things you mentioned above can cause Hypoglycemia? I did't know that. The reason I'm asking is because me cousin has Hypo. and he asked me if taking A.S. would be dangerous. I know he has to eat every half hour. I told him I didn't think it would be dangerous as long as he ate even more protien than what he needed to with his A.S. Basically do you think it would be dangerous or cause somthing like Diabeties?

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giantset
Amateur Bodybuilder
(Total posts: 98)
posted April 03, 2000 01:43 AM     Click Here to See the Profile for giantset   Click Here to Email giantset     Edit/Delete Message
Thanks macro. I have taken about 2.5 weeks off and I am back on now. I hope I will lose at least 5 lbs this week. I keep you posted on the results.

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macrophage69alpha
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(Total posts: 1115)
posted April 03, 2000 02:04 PM     Click Here to See the Profile for macrophage69alpha   Click Here to Email macrophage69alpha     Edit/Delete Message
d-town
more LOW GLYCEMIC carbs to keep blood sugar even.
DNP will not cause DIABETES
DIABETES TYPE I is most likely caused by a retrovirus/autoimmune disease where your body recognizes pancreatic beta cells as invaders.
diabetes type II- is insulin insensitivity and is easily controlled through diet, weight loss, exercise and supplementation

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MP

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D-Town
Pro Bodybuilder
(Total posts: 164)
posted April 03, 2000 02:39 PM     Click Here to See the Profile for D-Town   Click Here to Email D-Town     Edit/Delete Message
Thanks for the help Macro!!!

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macrophage69alpha
Moderator
(Total posts: 1115)
posted April 04, 2000 12:41 AM     Click Here to See the Profile for macrophage69alpha   Click Here to Email macrophage69alpha     Edit/Delete Message
bump

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MP

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