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 A STUDY TAKEN FROM MEDLINE ABOUT ALPHA LIPOIC ACID. VERY INTERESTING READING!
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| Author | Topic: A STUDY TAKEN FROM MEDLINE ABOUT ALPHA LIPOIC ACID. VERY INTERESTING READING! | ||
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Elite Bodybuilder 
Posts: 877 |
I THINK ALA MAY BE A VERY USEFULL SUPPLEMENT. I AM SURPRISED THIER HAVE NOT BEEN MORE DISSCUSIONS ABOUT THIS SUPPLEMENT DUE TO IT'S INSULIN MIMICKING ABILITIES. TAKEN FROM MEDLINE. Engagement of the insulin-sensitive pathway in the stimulation of glucose transport by alpha-lipoic
Yaworsky K; Somwar R; Ramlal T; Tritschler HJ; Klip A [Find other articles with these Authors] AIMS/HYPOTHESIS: A natural cofactor of mitochondrial dehydrogenase complexes and a potent antioxidant, Major Subject Heading(s) Find other articles with similar
Language: English     | ||
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Novice 
Posts: 4 |
ALA will increase carb uptake in fat and muscle cells about equally(some say more so in adipose). Sorry guys you will not get leaner by simply adding ALA into your daily regimine. I'm not trying to argue with what others have posted, but I worked on a study by a major U.S. university. For reasons of anonimity I can not give more details. But just like Metformin will not get you leaner neither will ALA. However, both are capable of helping to add more LBM and in that sense you could state that you have increased your BMR and thus indirectly given yourself the potential to lose more fat. However, this is an imperfect science. [This message has been edited by gy (edited March 14, 2001).] | ||
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Elite Bodybuilder
Posts: 1026 |
quote: Sorry to burst your bubble, but lipoic acid increases glut-4 levels in MUSCLE cells not FAT cells. Godspeed | ||
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Novice
Posts: 4 |
Sorry bro, but you need to re-read the medline article JS posted above. It talks about ALA's potentiation of glucose uptake in adipocytes not rhabdocytes. You see "adipocyte" is a synonim for fat cell. As stated previously, I'm not trying to argue, but the subjects I collected data on gained as much if not more fat mass as FFM. Hey it's up to you believe what you want but why do you think ALA is such a good suppl. for diabetics?...because it lowers blood glucose by cramming it into all available cells, not just muscle. It's pretty implausible to think that ALA is a magic compound that somehow can select Glut-4 R in muscle over fat cells just because it wants to be a nice guy and help us get BUFF lol. A glut-4 R is a glut-4 R no matter where it is located in-vivo. Not trying to flame you and I'm sure you have had good experience with it, but there is no way ALA is as "smart" as you say it is. If it were, hey no need for anabolic hormones since ALA will drive carbs into your sarcoplasm while tottally ignoring the exact same receptors on those mean old fat cells right next door, you should be getting huge and ripped just by tossing in a few more potatoes into each meal...I wish it was true, but sadly it is not. Please, I ask you to carefully re-read the article posted above. Thank you and good luck on your physique goals. | ||
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Moderator 
Posts: 5860 |
LOL...Good read... | ||
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Elite Bodybuilder
Posts: 1026 |
quote: I still disagree. 90% of all the studies I've read say that it increases glucose up-take to MUSCLE cells. And I well know what ADIPOCYTES ARE BTW....... Godspeed | ||
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Elite Bodybuilder
Posts: 877 |
YOU BOTH HAVE GOOD POINTS. BUT LET US KEEP THIS DISSCUSSION MATURE AND FLAME FREE. | ||
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Elite Bodybuilder
Posts: 1026 |
quote: Flame-free....LOL Definately not in my nature....... Godspeed | ||
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Cool Novice 
Posts: 44 |
So should I take my 200mg a day or not???.....you guys confused the HELL out of me...... ------------------ | ||
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Elite Bodybuilder
Posts: 1026 |
quote: herapeutical dose is 600mg a day. 200mg 3 times a day basically. Godspeed | ||
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Novice
Posts: 4 |
There has never been an agent that either directly or indirectly stimulates glucose deposition known to man, that can selectively shuttle said nutrient into muscle over fat or vice a versa. Insulin?...NO, Metformin?...NO, Rezulin?...NO, Actos?...NO, Glypizide...NO, Glyburide...NO, Vanadyl?...NO, Chromium?...NO...etc...Now here is a little bit of pharmaceutical grist for the mill concerning the now imfamous Rezulin. The company(PD) that manufactured Rezulin made an intentional error (in the opinions of some of their competitors) in the original package insert they released with the drug. This piece of literature stated that Rezulin selectively increased insulin sensitivity on muscle cells(with no mention of it's affect on adipocytes). Well desperate overweight diabetics and their endocrinologists immediately started Rx Rezulin as if God was running the GMP facility him/herself. Months later when returning patients were ready to sue their doctors and the company because they had experienced a hefty gain of weight(not all of it quality) despite attenuated Hgb A1c levels, this little tity of pharmaceutical fairy tale was quickly denounced and ammended for fear of legal action. Only a short time later this miracle drug was taken off the market due to a nasty little side effect involving the hepato-biliary system. What is the moral of this story? When it comes to glucose uptake love sees no boundaries...Wether it's your ass or biceps femoris, that sugar wants in and it doesn't care what type of cell it is. Except post INTENSE workout blah, blah, blah. Anyway it's time for tea and crumpets and I am running unforgivably late. Cheerio. | ||
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Amateur Bodybuilder 
Posts: 118 |
This is a healthy, positive discussion. There's disagreement on just about every supplement I've come across and heard about so this is nothing new to me. ALA is definitely good for us, no one disagrees with that. I'm still going to take it and I'll post my results from it. | ||
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Elite Bodybuilder
Posts: 1026 |
[QUOTE]Originally posted by gy: [B]There has never been an agent that either directly or indirectly stimulates glucose deposition known to man, that can selectively shuttle said nutrient into muscle over fat or vice a versa. Insulin?...NO, Metformin?...NO, Rezulin?...NO, Actos?...NO, Glypizide...NO, Glyburide...NO, Vanadyl?...NO, Chromium?...NO...etc...Now here is a little bit of pharmaceutical grist for the mill concerning the now imfamous Rezulin. The company(PD) that manufactured Rezulin made an intentional error (in the opinions of some of their competitors) in the original package insert they released with the drug. This piece of literature stated that Rezulin selectively increased insulin sensitivity on muscle cells(with no mention of it's affect on adipocytes). Well desperate overweight diabetics and their endocrinologists immediately started Rx Rezulin as if God was running the GMP facility him/herself. Months later when returning patients were ready to sue their doctors and the company because they had experienced a hefty gain of weight(not all of it quality) despite attenuated Hgb A1c levels, this little tity of pharmaceutical fairy tale was quickly denounced and ammended for fear of legal action. Only a short time later this miracle drug was taken off the market due to a nasty little side effect involving the hepato-biliary system. What is the moral of this story? When it comes to glucose uptake love sees no boundaries...Wether it's your ass or biceps femoris, tha Get your head out of your ass....LOL!!!! In all the studies, ALA increased glycogen storage when calories were kept the same. So please tell me how on earth ALA incrased glucose disposal to the fat cells if the subjects in question did not gain any bodyfat, just bodyweight(from the increased glycogen storage)!!!????? Godspeed | ||
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Elite Bodybuilder
Posts: 642 |
Great posts, GY. Don't mind Fonz... In his little brain he believes that saying other people are wrong validates his credibility. He is a typical kid that knows just enough to sound like he is talking about and has had just enough school to know how to use the big words... just not enough to know exactly what they mean. No study can prove him wrong because he believes that he gets closer and closer to being a mod by trying to establish himself as having intellectual intuition that is above science, reason, logic, and research. I'm glad to see another bro on this board that has some sense. Not everyone is like Fonz and I'm sure that if you hang around you'll grow to like this board. You'll just have to overlook some people. That's cool that you're in research... I'm awaiting my first publication as a first author on my research at the University of Louisiana at Monroe. Good posts! -Stew -Stew | ||
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Novice
Posts: 4 |
Dear Fraud...I mean Fonz, Now you've done it, you have disturbed my afternoon tea...I must punish you. First of all I beg of you to slowly and gently remove the cock stuck in your ass and insert it firmly in your mouth. This should help to rectify the diarrehea of the mouth you seem to be suffering from on a chronic basis. Now let's move on to more pertinent matters... I will make a mockery of you quickly but painfully. You state that in the studies you have had read to you..I mean that you have read yourself, that glucose uptake was increased, well it certainly was not only taken up by muscle cells but also fat cells because for the last time the mechanism for cellular uptake that ALA modulates is exactly the same. ALA is not Albert Einstein, it is not ingenious enough to decipher the difference between the membranes of the two cell types that use the exact same receptors. Your intelligence is as remedial as your face is grotesque, because you are failing to see the obvious...ALA does not effect the cells, it manipulates the enzymes and receptors that both cell types contain. It could care less if these pathways were present in muscle, fat, nervous tissue or any other suitable biological compartment. Again: IT DOES NOT AFFECT THE CELL...IT AFFECTS THE COMPONENTS THAT ARE FOUND IN BOTH MUSCLE AND FAT. Furthermore, you state that bodyweight increased but bodyfat did not. No reputable study would measure "bodyweight" or "bodyfat", rather they would measure Fat Free Mass, Fat Mass, and so on...to qualitate their findings. But by all means Doctor Dipshit, please post these scientific studies so that you may prove me wrong. However, I believe these clinical trials were either done at U.C.L.A (the University of Clueless Lame Asses) or simply don't exist. I must apologize to the members of this board, as I certainly did not come here to spew such venom but some need a reminding of their own worthlessness from time to time. Hey sometimes you gotta take out the garbage. Fonz, I also apologize to you and your loved ones for exposing your shortcomings, but I'm sure your significant other, Mr. Cunningham, already knew about your lack of male fortitude. I am finished with you and will not respond to any forth coming message you may wish to post. Please enjoy the rest of your evening. Ole! | ||
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Amateur Bodybuilder
Posts: 181 |
Bump for Macro, Meanone, E2, 2Thick, or anyone else who can clear up this drama. I take this supplement and am curios on the truth! | ||
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Moderator
Posts: 1751 |
GY, in my opinion, is correct with respect to Non-selective action. However, ALA's impact on insulin production- which should be down regulated in the face of increased insulin sensitivity- will have an impact on cellular disposition of blood glucose. In addition- from anecdotal evidence, it does not seem that those taking ALA have increased bodyfat.
Peace ------------------ | ||
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Elite Bodybuilder
Posts: 1026 |
quote: Thanks Macro. That's a very interesting insight on anabolism. Going to have to research that aspect more in depth. Godspeed | ||
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Pro Bodybuilder 
Posts: 481 |
so gy ar3e you saying that anyone who is interested in fatloss should avoid ala? |
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posted March 14, 2001 03:14 PM