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To optimise your next cycle, you may want to choose gear that A. wouldn't suppress your LH/LHRH (your natural hormone production) so that your hormonal axis can recouperate while you still see anabolic benefits from a cycle. Primobolan and Anavar would be excellent choices, and along with Clen, ECA, and perhaps PGF2a, could substitute as an excellent follup cycle allowing you to shed some of the fat that accumilated from the former cycle and still be able to add more lean mass. A. would need less time off and possibly even no time (considering you employ clomid and HCG therapy).

B. you could use AS that would react with androgen receptors via different enzymatic pathways. Different enzymes are used not only to metabolise different meds, but to enable the steroid to reach its substrate level so that it may bind to the androgen receptor.
All androgens are not equal, but all bind to the same receptor.

In truth, the metabolic process a.k.a. the tolerance effect, can have more of an influence on the effects of the cycle and duration of off-time and would have almost nothing to do with receptors. In fact, you will actually GAIN receptors for the anabolic steroids as you inject them. These gains take time to occur and are more time dependant than dose dependent. Receptors will not downregulate meaning the binding affinity does not deminsh due to the addition of exogenous hormone.

Why does everyone think that androgen receptors are these static molecules that you've had since the day you were born? Androgen receptors have half lives just like drugs do. You gain new AR's each day.. Likewise, you metabolize AR's everyday.

Immunity to gear? What a load of shit. Not only are all androgen receptors completely identical, the one's of today dont know which steroids bound the one's of yesterday.

Steroids that activate AR's are not altered beforehand. Otherwise, they would be different molecules and wouldnt activate the receptor (duh).

FOLLOWING activation, the steroid may be metabolized and/or have groups such as sugars added to them to make them more water soluble and more easily excreted.

Different steroids can have different affinities for these enzymes that alter them.. That is one factor to be included in total effectiveness of the drug.

Back to "clearing the receptors"... Why would you want to do that in the first place? A steroid that binds a receptor is a good thing!!! It's not like the steroid binds the receptor and does it's job and then just hangs on to it making it inactive. As long as the steroid is in the active site of the receptor, the receptor will have a nuclear localization sequence exposed so that it may be imported into the nucleus to begin transcription. Different steroids have different affinities for ARs (as you know) and so the rate of transcription of that particular DNA sequence may be increased accordingly.

Were are not talking about a steroids affinity for that AR.. Or the AR's ability to bind the steroid. "upregulation" means that the transcription factors are activated upstream of the DNA sequence coding for the androgen receptor. The end result is MORE ar's.. This DOES NOT MEAN that the AR's are any better or worse at binding steroids as all AR's are identical and have the same ability to bind a particular steroid.

Likewise, "downregulation" means that the DNA sequence coding for the AR is transcribed at a lower rate than before.

RECAP--

UPregulation means there are more ARs per cell than before

DOWNregulation means that there are LESS AR's per cell than before.

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Originally posted by Hero:
Man, you guys really know your stuff.It's reading post like these that I realize how much I don't know!!So are you saying then that if someone just finished a 12 wk decca/sus cycle say 400mg/500mg,that it would be better to continue with say 5-6wks of fina before going on clomid therapy??

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Why would that be better? I guess I dont understand the question.