posted March 18, 2000 08:08 PM            

Sorry, i will look and see what i can find.

posted March 18, 2000 08:43 PM            

Oxymetholone

Pronunciation (oks i METH oh lone)

Brand Names Anadrol�

Canadian/Mexican Brand Names Anapolon� (Canada)

Therapeutic Category
Androgen
Use Anemias caused by the administration of myelotoxic drugs

Restrictions C-III

Pregnancy Risk Factor X

Contraindications Carcinoma of breast or prostate, nephrosis, pregnancy, hypersensitivity to any component

Warnings/Precautions Anabolic steroids may cause peliosis hepatis, liver cell tumors, and blood lipid changes with increased risk of arteriosclerosis; monitor diabetic patients carefully; use with caution in elderly patients, they may be at greater risk for prostatic hypertrophy; use with caution in patients with cardiac, renal, or hepatic disease or epilepsy

Adverse Reactions
Male:

Postpubertal:

>10%:

Dermatologic: Acne

Endocrine & metabolic: Gynecomastia

Genitourinary: Bladder irritability, priapism

1% to 10%:

Central nervous system: Insomnia, chills

Endocrine & metabolic: Decreased libido

Gastrointestinal: Nausea, diarrhea

Genitourinary: Prostatic hypertrophy (elderly)

Hematologic: Iron deficiency anemia, suppression of clotting factors

Hepatic: Hepatic dysfunction

<1%:

Hepatic: Hepatic necrosis, hepatocellular carcinoma

Prepubertal:

>10%:

Dermatologic: Acne

Endocrine & metabolic: Virilism

1% to 10%:

Central nervous system: Chills, insomnia

Dermatologic: Hyperpigmentation

Gastrointestinal: Diarrhea, nausea

Hematologic: Iron deficiency anemia, suppression of clotting factors

<1%: Hepatic: Hepatic necrosis, hepatocellular carcinoma

Female:

>10%: Endocrine & metabolic: Virilism

1% to 10%:

Central nervous system: Chills, insomnia

Endocrine & metabolic: Hypercalcemia

Gastrointestinal: Nausea, diarrhea

Hematologic: Iron deficiency anemia, suppression of clotting factors

Hepatic: Hepatic dysfunction

<1%: Hepatic: Hepatic necrosis, hepatocellular carcinoma

Overdosage/Toxicology Abnormal liver function test

Drug Interactions Increased toxicity: Increased oral anticoagulants, insulin requirements may be decreased

Mechanism of Action Stimulates receptors in organs and tissues to promote growth and development of male sex organs and maintains secondary sex characteristics in androgen-deficient males

Pharmacodynamics/Kinetics
Half-life: 9 hours

Elimination: Primarily in urine

Usual Dosage Adults: Erythropoietic effects: Oral: 1-5 mg/kg/day in 1 daily dose; maximum: 100 mg/day; give for a minimum trial of 3-6 months because response may be delayed

Monitoring Parameters Liver function tests

Test Interactions Altered glucose tolerance tests, altered thyroid function tests, altered metyrapone tests

Dosage Forms Tablet: 50 mg