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  Endogenous T-production and clomid therapy...

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Author Topic:   Endogenous T-production and clomid therapy...
HUCKLEBERRY FINNaplex

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From:Timbuktu
Registered: Jan 2000

posted February 17, 2001 12:48 PM

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I posted this on another thread,but wanted to make sure everyone got a chance to read it,as there's still some confusion regarding the whole clomid therapy issue...

Testosterone production begins at the hypothalamus,which scans blood levels of estrogens,androgens and other pertinent hormones.In a presence of low androgens and estrogens the hypothalamus will produce leutenizing-hormone-releasing-hormone(LHRH)which in turn stimulates the pituitary to produce leutenizing hormone(LH).LH then signals the leydig cells in the testicles to begin producing testosterone.Hence the Hypothalamic Pituitary Testicular Axis,as production is ran in that order.Now on to the clomid...

Clomid is a selective estrogen receptor modulator(much like nolvadex,only their binding capacities are more aggressive in seperate areas).Clomid stimulates L-H-R-H/LH production by binding to ESTROGEN receptors on the hypothalamus and pituitary,thus giving the illusion of a low presence of circulating estrogen.Note the key word here-ESTROGEN.CLOMID DOES NOT BIND ANDROGEN.Therefore,on a cycle of moderate to high amounts of ANDROGENS,clomid will have no effect whatsoever on endogenous testosterone production,as we are in a state of ANDROGENIC inhibition.It's post cycle,when blood levels of androgens begin to normalize and the typical estrogenic rebound/lag occurs,that clomid is able to re-initialize this process of testosterone production.Hope this clears up how clomid works and why to save it for post cycle,unless you're using it as an anti-estrogen.---Huck

[This message has been edited by HUCKLEBERRY FINNaplex (edited February 17, 2001).]


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BIG HURT

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From:COMISKEY PARK
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posted February 17, 2001 12:59 PM

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Huck,I'm interested to hear your opinion/theory,on the proper way to use clomid,i.e.,when to start it postcycle,at what dosage,and the duration of intake.

------------------
CUBS SUCK


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Fener

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From:rome italy
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posted February 17, 2001 01:10 PM

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hey huck, great post,but please help us all with a major problem with clomid: acne.at the end of the cycle you're supposed to look at your best, expecially if it was a cutting cycle.So what's the matter of building a great phisyque if you cant take your shirt off?give us a good way to really prevent acne form coming while using clomid, because i think once you have it you'll keep it for a few months


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HUCKLEBERRY FINNaplex

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posted February 17, 2001 01:17 PM

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First you have to figure out the activity life/clearance time of your particular ester.They don't have to be completely cleared from your system,just enough that androgen levels are within normal to high normal ranges.For instance sust's longest acting and most potent ester,the undecanoate ester clears your system in roughly 3-4 weeks.So beginning clomid therapy 3 weeks after your last injection would be ideal.This is the pattern I would run my clomid in...

Day 1)300mgs...2 tabs every 4 hours or so.This will drive up blood levels of the drug for an immediate "therapeutic" response(one that would normally take many consecutive days of usage to be reached)and get the drug working aggressively towards re-initializing endogenous hormonal production.

Days 2-11)100mgs/day(bothtabs can be taken together now,as it's half life is so long it will make no difference...

Days 12-21)50mgs/day...

Day 22)DONE!


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littlearnold1069

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From:Houston, TX Reside: Hattiesburg, MS
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posted February 17, 2001 01:27 PM

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i like the way you use clomid huck

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BIG HURT

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From:COMISKEY PARK
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posted February 17, 2001 01:30 PM

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Very informative info. Huck!Straight and to the point.This should be a permanent(non-responding) post at the top of the board.It will put an end all to the worry,head spinning questions, and use of clomid.

Good info Huck!Makes the most sense.Thanks

------------------
CUBS SUCK


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Daeo

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posted February 17, 2001 01:31 PM

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That's the way I'm taking clomid now also. I'm already shooting bigger loads..

------------------

The Other Board.


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'ORCHITIS'

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posted February 17, 2001 01:31 PM

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I like that method also, and I think I'll give it a try next time.....oh, wait....I don't use or condone the use of AS. Sorry guys, but that sure is some good info for all you CRAZY juicers

------------------
'This is what it's all about'


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HUCKLEBERRY FINNaplex

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From:Timbuktu
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posted February 17, 2001 01:34 PM

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None of us do.This just a disussion board for informative purposes only


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Stealth Assasin

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From:One Step Behind Ya
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posted February 17, 2001 01:34 PM

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quote:
Originally posted by Daeo:
I'm already shooting bigger loads..



Porn start size loads?

Great post


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Jeff_rys

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From:The future a 1000 years from now
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posted February 17, 2001 01:46 PM

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saved to disk.

------------------
Jeff

Don't look back, life is too short


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CB38AC

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posted February 17, 2001 02:13 PM

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what about how it helps stop your nuts from shrinking? isn't that a good reson to use it durring cycle?


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Sadist

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From:St.Louis
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posted February 17, 2001 02:14 PM

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bump this up!


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hooch

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posted February 17, 2001 07:30 PM

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There should be a Steroid FAQ on here someplace...and Hucks post should be on it


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HUCKLEBERRY FINNaplex

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From:Timbuktu
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posted February 17, 2001 11:04 PM

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Please keep this bumped for a while fellas,as it will help answer a lot of bro's questions...


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Transcend1

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posted February 17, 2001 11:11 PM

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Excellent post - as always Huck.


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ROIDRANGER

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posted February 17, 2001 11:11 PM

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ill bump 4 huck

also i agree w/ a steroid FAQ section--it'd be nice...

------------------
power to gain from the ROIDRANGER.


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ItalianSweetness

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posted February 17, 2001 11:22 PM

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thats almost exactly how i used my clomid after last cycle. Good info for all the new guys.

----During a cycle for cutting purposes....does clomid cause more water to be retained? Would novaldex be better for eliminating the chance of gyno AND getting rid of excess water?

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~~~~~~~In order to look UNIQUE.....you have to eat UNIQUE.~~~~~~~


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Holy souldier

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posted February 18, 2001 12:32 AM

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bump


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BerkeleyJuice

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From:Redding
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posted February 18, 2001 03:44 AM

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Hey Huck, if you take proviron at the end also, would you have to take as much Clomid? I was planning on taking 25mg Proviron eod for 2 weeks at the end of my cycle and 50 mg Clomid ed 10 days after my last injection of enathate. What do you thinK?


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TheDragon

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posted February 18, 2001 06:19 AM

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Bump...very good info..thanks Huck


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Tomo

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posted February 18, 2001 06:24 AM

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huck- what about lower levels for a longer period of time


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Juice Monkey

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posted February 18, 2001 10:51 AM

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I agree with HUCK's reasoning. It's what I've been advocating for years. Hopefully everyone will listen.

------------------
I am the original JM
Author of "The GainsKeeper Formula" and
Co-Author of "Secrets of Mail Order Success"


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Daeo

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posted February 18, 2001 01:21 PM

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------------------

The Other Board.


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BRICK

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posted February 18, 2001 01:27 PM

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thanks Huck great post...


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lawnsaver

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posted February 18, 2001 01:32 PM

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quote:
Originally posted by BerkeleyJuice:
Hey Huck, if you take proviron at the end also, would you have to take as much Clomid? I was planning on taking 25mg Proviron eod for 2 weeks at the end of my cycle and 50 mg Clomid ed 10 days after my last injection of enathate. What do you thinK?

Proviron wont help with test production. It is a weak androgen, which will hinder natural test at high levels. A low dose of proviron(25mg to 50mg) will help keep eccess estrogen down and help with errections. Clomid will still be needed at those doses.

------------------
" That which does not kill me, will make me stronger"

"Catch a man a fish, he eats for a day. Teach a man to fish, and he eats for a lifetime."


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pittbull2

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posted February 18, 2001 01:46 PM

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Very good post Huck!


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way2thin

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posted February 18, 2001 01:58 PM

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Great advice bump for huck


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MeanOne

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posted February 18, 2001 02:37 PM

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GASP.....Excellent post Huck! Reminds me of an email....lol

Anyway, here's a hypothetical question for you. If HCG works to directly stimulate the leydig cells in the testicles to begin producing testosterone, much like LH does, would using maybe small amounts (2500iu/wk) not be of benefit while on cycle. My train og thought here is that by keeping the testicles stimulated, they wouldn't lay unused for so long, which would quicken there response to the increased LH levels brought about by the clomid.

In other words, HCG to keep you nuts working, clomid to begin to make the other glands of the body work, for the quickest possible recovery.

Oh yeah, and a big ole' fat ass BUMP


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pittsburgh*

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posted February 18, 2001 02:46 PM

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Men get their estrogen ONLY from the aromatization of testosterone. if Clomid increases LH levels and LH stimulates the testes to produce testosterone then clomid during androgen therapy will keep the testes producing testosterone...therefore no "ball shrinkage".
the only way for the hypothalamus to normalize estrogen levels is to increase test levels with LH.


clomid---LH---testosterone--estrogen.


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HUCKLEBERRY FINNaplex

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From:Timbuktu
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posted February 18, 2001 02:50 PM

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Great thinking,as always meanone.E2 really hates HCG with a passion,but if one really is concerned with testicular atrophy during a cycle,I think it is a decent option.Short,intermittent bursts of HCG could be used during the cycle to stimulate the testes to grow,then clomid can work its magic post cycle.Just make sure your using an anti-estrogen while hitting the HCG,as it raises estrogen levels appreciably as well,haha...


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hooch

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posted February 18, 2001 04:42 PM

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bump for newbies


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HUCKLEBERRY FINNaplex

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posted February 18, 2001 11:21 PM

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I can't believe this was already in the middle of the second page and there's like a half dozen clomid questions on page 1...Keep it bumped for a while fellas...


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Keep it beefy

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posted February 18, 2001 11:51 PM

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Why do high levels of androgens preclude the process that you described above huck? You said that it(clomid) binds to estrogen receptors in the hypothalumus and pituitary(which is what raises LH and FSH levels) Doesn't this override the negative feedback induced by high levels of androgens? Obviously it does, because those who use clomid mid cycle, keep there balls hypertrophied(by keeping endogenous test levels up).


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HUCKLEBERRY FINNaplex

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posted February 19, 2001 12:07 AM

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I can't explain exactly what it is occurring to keep the testes full,but I can tell you that it isn't LH production.Dr. Raymond Scruggs who specializes in hormonal therapy and has the chartwork of multitudes of patients upon patients has conferred with me on this and all of his patients bloodwork have come back with zeroed out LH production EVEN WHILE ADMINISTERING CLOMID DURING A CYCLE.Reknowned Guru Bill Roberts confers this as well.So as stated above,ANDROGENS themselves will shut down endogenous T production,even in a presence of suppressed estrogen.Don't equate your testicles not atrophying with LH production,because it's not always as simple as that...


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yiyangzhi

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From:Ipoh
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posted February 19, 2001 05:46 AM

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Keep this thread bumped high up.


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PokeMeMon

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posted February 19, 2001 10:19 AM

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bump


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Daeo

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posted February 19, 2001 12:17 PM

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------------------

The Other Board.


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greenhouse

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posted February 19, 2001 12:24 PM

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Nice one Huck...

Bump, in case some guys have some Q's for ya...

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hayesjones

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posted February 19, 2001 01:25 PM

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Nice 411 Huck! Thats why George has you on the throne!


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