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Author | Topic: GRAPEFRUIT: IT IMPROVES ORAL DRUG ABSORPTION (DBOL) !!! | ||
Elite Bodybuilder ![]() ![]() ![]() Posts: 1357 |
Hey Boys, Upon reading a comment on Grape Fruit Juice by E2. I started reading. I found a couple very interesting articles: They are all short so go ahead and read them. They say This is good because that enzyme is responsible to breaking down drugs. ------------------ ![]() ![]() ![]() ![]() | ||
Amateur Bodybuilder ![]() ![]() Posts: 204 |
DREXX..Good info bro.Got a question..I still have your 2on/2off cycle "experiment"--and I eventually plan on trying this out.Using Prop instead of Enanthate.But I don't understand Metformin and what this is or what it does for you.Yes I searched damn it.lol.no good input.Could you elaborate for me what this is and how you incorporated it's effects into your ..hehe..experiment? ------------------ ![]() ![]() ![]() ![]() | ||
Elite Bodybuilder ![]() ![]() ![]() Posts: 1357 |
Hey, By the way its 2on/4off. I may have posted 2on/2off by accident. It's best to take 4 weeks off and I have done 3 weeks off before with good results. Metformin = Glucophage It is basically an oral diabetes medicine. It has similar effect as insulin however this doesn't increase insulin levels. It makes your insulin recpetors more receptive. Great for people who are insulin resistant. It helps a little but I found that it doesn't work enough to keep using it so I stopped using it. Using Glutamine/Creatine when you come off the cycle should be as effective. ------------------ ![]() ![]() ![]() ![]() | ||
Pro Bodybuilder ![]() ![]() ![]() Posts: 568 |
I just finished a cycle, 4 on, gonna go 6 off, maybe 8, depending on stats. I did 2 on 4 off almost all last year at low dosages of Sust/deca, and Sust/primo/winny ![]() ![]() ![]() ![]() | ||
Amateur Bodybuilder ![]() ![]() Posts: 186 |
Try adding Bioprene and/or LPC to your oral stack...both are proposed to increase absorbtion of oral compounds. ![]() ![]() ![]() | ||
Amateur Bodybuilder ![]() ![]() Posts: 92 |
Thats some good info. Thanx Drexx InstantGrowth ![]() ![]() ![]() ![]() | ||
Cool Novice ![]() ![]() Posts: 48 |
thanks for the info drexx, im about to start some dbol. one question though, how much grapefruit juice should be enough? ![]() ![]() ![]() | ||
Amateur Bodybuilder ![]() ![]() Posts: 204 |
Thanks DREXX for the return input.Let me know if you are planning another experiment ![]() ------------------ ![]() ![]() ![]() ![]() | ||
Pro Bodybuilder ![]() ![]() ![]() Posts: 493 |
good info Drexx ------------------ ![]() ![]() ![]() ![]() | ||
Amateur Bodybuilder ![]() ![]() Posts: 149 |
GOOD POST...we need more like this. Thanks for the info! ![]() ![]() ![]() ![]() | ||
Amateur Bodybuilder ![]() ![]() Posts: 95 |
I have heard about this some years ago now but unfortunately I don't think it works with steroids. Please tell me I am wrong? It only works on certain types of drugs. ![]() ![]() ![]() ![]() | ||
Pro Bodybuilder ![]() ![]() ![]() Posts: 575 |
Very Interesting. Great Post!! Mass Monster ![]() ![]() ![]() ![]() | ||
Pro Bodybuilder ![]() ![]() ![]() Posts: 515 |
Oh, really? I gotta go guys. Grapefriut juice is waiting me in the supermarket ![]() ![]() ![]() ![]() ![]() | ||
Elite Bodybuilder ![]() ![]() ![]() Posts: 1357 |
shoulders: The grapefruit inhibits an enzyme in the liver that is responsable for breaking down foreign objects such as drugs. When this enzyme is inhibited the drug skips a step and keeps going. It should work with any oral drug since less of it is degraded by the first phase enzyme. ------------------ ![]() ![]() ![]() ![]() | ||
Amateur Bodybuilder ![]() ![]() Posts: 102 |
No flame intended Drexx. Grapefruit does not improve the absorption of drugs. A compond found in grapefruit juice can slow down the rate of metabolism of certain drugs that are metabolized by certain cytochrome p450 (Liver) enzymes (CYP3A4 and CYP1A2). There are many other p450 enzymes (as well as non-p450 enzymes) that are responsible for metabolizing a wide range of drugs. I don't think that the primary metabolic pathway of DBol (or any other oral steroids) is through CYP3A4 and CYP1A2. Grapefruit would therefore have little effect on oral steroid metabolism. It certainly would be nice, but we cannot generalize this effect to steroids. ![]() ![]() ![]() ![]() | ||
Amateur Bodybuilder ![]() ![]() Posts: 135 |
Just to add on. Grapefruit juice has been shown to stress the kidneys and may cause gallstones if taken regularly. Grapefruit does contains trace amounts of HMB, good for those who are already on HMB supplements. [This message has been edited by yiyangzhi (edited February 16, 2001).] ![]() ![]() ![]() ![]() | ||
Elite Bodybuilder ![]() ![]() ![]() Posts: 601 |
Grapefruit constituents (naringen, bergapten, quercetin) have been shown to increase the availability of some steroidal compounds, namely estrogens and corticosteroids. I do not know if the enzymes that metabolize estrogens are different than that for androgens, but since it has been shown to increase estrogens AND corticosteroids, I would imagine it does the same for androgens. This could be both beneficial and deleterious, since one would get higher levels of androgens, but any estrogens formed may reside in the body for longer than normal. ![]() ![]() ![]() | ||
Amateur Bodybuilder ![]() ![]() Posts: 53 |
Good info bro... But does this mean that grapefruit can in any way contribute undirectly to liver damage. I mean, since it destroys this enzyme used to break down the drug, does it require more "passes" through the liver in order to be broken down? ![]() ![]() ![]() ![]() | ||
Cool Novice ![]() ![]() Posts: 38 |
This is very true but quantifying the increase is nearly impossible. Sometimes this could be good but it could be dangerous for people on heart drugs, etc. ![]() ![]() ![]() ![]() | ||
Pro Bodybuilder ![]() ![]() ![]() Posts: 477 |
DREXX YOU HAVE MAIL! ![]() ![]() ![]() ![]() | ||
Amateur Bodybuilder ![]() ![]() Posts: 142 |
i don't care... grapefruit juice taste like shit anyway! ![]() ![]() ![]() | ||
Cool Novice ![]() ![]() Posts: 26 |
i think that is great info and it will probably help a lot of guys on this bored that are taking orals...like my guy ..he had liver problems after taking orals now he can take the orals he wants without me being so worried ![]() Roxy ![]() ![]() ![]() ![]() |
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