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  GRAPEFRUIT: IT IMPROVES ORAL DRUG ABSORPTION (DBOL) !!!

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Author Topic:   GRAPEFRUIT: IT IMPROVES ORAL DRUG ABSORPTION (DBOL) !!!
DREXX

Elite Bodybuilder

Posts: 1357
From:Canada
Registered: May 2000

posted February 15, 2001 03:08 PM

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Hey Boys,

Upon reading a comment on Grape Fruit Juice by E2. I started reading.

I found a couple very interesting articles:
http://www.media.wayne.edu/iws.back.issues/iws3_6_97/grapefruit.html http://www.heartinfo.org/science/grapefruit41698.htm http://umcnews.com/askthepharmacist/grapefruitjuice.html

They are all short so go ahead and read them. They say
that something grapefruit destroys an enzyme produced by the liver.

This is good because that enzyme is responsible to breaking down drugs.
If you take grapefruit juice with your oral drugs you can expect to use
up to 30% more of it.

------------------
If it's not hard it's not worth doing...


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DIXIEBOY

Amateur Bodybuilder

Posts: 204
From:MAN-WHOREVILLE
Registered: Jan 2001

posted February 15, 2001 03:18 PM

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DREXX..Good info bro.Got a question..I still have your 2on/2off cycle "experiment"--and I eventually plan on trying this out.Using Prop instead of Enanthate.But I don't understand Metformin and what this is or what it does for you.Yes I searched damn it.lol.no good input.Could you elaborate for me what this is and how you incorporated it's effects into your ..hehe..experiment?

------------------


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DREXX

Elite Bodybuilder

Posts: 1357
From:Canada
Registered: May 2000

posted February 15, 2001 03:39 PM

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Hey,

By the way its 2on/4off. I may have posted 2on/2off by accident. It's best to take 4 weeks off and I have done 3 weeks off before with good results.

Metformin = Glucophage

It is basically an oral diabetes medicine. It has similar effect as insulin however this doesn't increase insulin levels. It makes your insulin recpetors more receptive.

Great for people who are insulin resistant.

It helps a little but I found that it doesn't work enough to keep using it so I stopped using it.

Using Glutamine/Creatine when you come off the cycle should be as effective.

------------------
If it's not hard it's not worth doing...


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Adonis

Pro Bodybuilder

Posts: 568
From:Central Cal
Registered: Jan 2000

posted February 15, 2001 03:45 PM

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I just finished a cycle, 4 on, gonna go 6 off, maybe 8, depending on stats. I did 2 on 4 off almost all last year at low dosages of Sust/deca, and Sust/primo/winny


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Phreaky

Amateur Bodybuilder

Posts: 186
From:
Registered: Mar 2000

posted February 15, 2001 03:50 PM

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Try adding Bioprene and/or LPC to your oral stack...both are proposed to increase absorbtion of oral compounds.


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InstantGrowth

Amateur Bodybuilder

Posts: 92
From:Cali
Registered: Oct 1999

posted February 15, 2001 04:44 PM

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Thats some good info. Thanx Drexx
InstantGrowth


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WaNNaJuiCe

Cool Novice

Posts: 48
From:Eunice,LA,U
Registered: Jun 2000

posted February 15, 2001 05:02 PM

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thanks for the info drexx, im about to start some dbol. one question though, how much grapefruit juice should be enough?


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DIXIEBOY

Amateur Bodybuilder

Posts: 204
From:MAN-WHOREVILLE
Registered: Jan 2001

posted February 15, 2001 05:06 PM

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Thanks DREXX for the return input.Let me know if you are planning another experiment

------------------


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littlearnold1069

Pro Bodybuilder

Posts: 493
From:Houston, TX Reside: Hattiesburg, MS
Registered: Dec 2000

posted February 15, 2001 07:56 PM

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good info Drexx

------------------
Please visit my website - Http://thewrightstuff2k.tripod.com


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LittleSavage34

Amateur Bodybuilder

Posts: 149
From:
Registered: Sep 2000

posted February 15, 2001 08:38 PM

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GOOD POST...we need more like this. Thanks for the info!


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shoulders

Amateur Bodybuilder

Posts: 95
From:Gold Coast Queensland Australia
Registered: Jun 2000

posted February 16, 2001 05:35 AM

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I have heard about this some years ago now but unfortunately I don't think it works with steroids. Please tell me I am wrong? It only works on certain types of drugs.


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Mass Monster

Pro Bodybuilder

Posts: 575
From:
Registered: Dec 2000

posted February 16, 2001 05:45 AM

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Very Interesting. Great Post!!

Mass Monster


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Retabolil2

Pro Bodybuilder

Posts: 515
From:Steroid Land
Registered: Aug 2000

posted February 16, 2001 06:33 AM

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Oh, really? I gotta go guys. Grapefriut juice is waiting me in the supermarket


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DREXX

Elite Bodybuilder

Posts: 1357
From:Canada
Registered: May 2000

posted February 16, 2001 10:10 AM

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shoulders:

The grapefruit inhibits an enzyme in the liver that is responsable for breaking down foreign objects such as drugs.

When this enzyme is inhibited the drug skips a step and keeps going. It should work with any oral drug since less of it is degraded by the first phase enzyme.

------------------
If it's not hard it's not worth doing...


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E-Toon

Amateur Bodybuilder

Posts: 102
From:Massachusetts
Registered: Jun 2000

posted February 16, 2001 10:14 AM

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No flame intended Drexx.

Grapefruit does not improve the absorption of drugs. A compond found in grapefruit juice can slow down the rate of metabolism of certain drugs that are metabolized by certain cytochrome p450 (Liver) enzymes (CYP3A4 and CYP1A2). There are many other p450 enzymes (as well as non-p450 enzymes) that are responsible for metabolizing a wide range of drugs.

I don't think that the primary metabolic pathway of DBol (or any other oral steroids) is through CYP3A4 and CYP1A2. Grapefruit would therefore have little effect on oral steroid metabolism. It certainly would be nice, but we cannot generalize this effect to steroids.


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yiyangzhi

Amateur Bodybuilder

Posts: 135
From:Ipoh
Registered: Dec 2000

posted February 16, 2001 10:31 AM

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Just to add on. Grapefruit juice has been shown to stress the kidneys and may cause gallstones if taken regularly. Grapefruit does contains trace amounts of HMB, good for those who are already on HMB supplements.

[This message has been edited by yiyangzhi (edited February 16, 2001).]


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cockdezl

Elite Bodybuilder

Posts: 601
From:
Registered: 2000

posted February 16, 2001 01:33 PM

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Grapefruit constituents (naringen, bergapten, quercetin) have been shown to increase the availability of some steroidal compounds, namely estrogens and corticosteroids. I do not know if the enzymes that metabolize estrogens are different than that for androgens, but since it has been shown to increase estrogens AND corticosteroids, I would imagine it does the same for androgens.

This could be both beneficial and deleterious, since one would get higher levels of androgens, but any estrogens formed may reside in the body for longer than normal.


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Unnatural

Amateur Bodybuilder

Posts: 53
From:
Registered: Jan 2001

posted February 16, 2001 01:55 PM

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Good info bro...
But does this mean that grapefruit can in any way contribute undirectly to liver damage. I mean, since it destroys this enzyme used to break down the drug, does it require more "passes" through the liver in order to be broken down?


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40butpumpin

Cool Novice

Posts: 38
From:Schenectady, NY USA
Registered: Feb 2001

posted February 16, 2001 04:50 PM

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This is very true but quantifying the increase is nearly impossible. Sometimes this could be good but it could be dangerous for people on heart drugs, etc.


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Wynn

Pro Bodybuilder

Posts: 477
From:NJ,USA
Registered: Feb 2000

posted February 16, 2001 08:57 PM

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DREXX YOU HAVE MAIL!


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avenger

Amateur Bodybuilder

Posts: 142
From:the underground
Registered: Feb 2001

posted February 16, 2001 10:21 PM

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i don't care... grapefruit juice taste like shit anyway!


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Roxy_Chic

Cool Novice

Posts: 26
From:bakersfield
Registered: Oct 2000

posted February 16, 2001 10:25 PM

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i think that is great info and it will probably help a lot of guys on this bored that are taking orals...like my guy ..he had liver problems after taking orals now he can take the orals he wants without me being so worried thankx!
Roxy


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