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  Which OTC pain killers are hepatoxitic?

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Author Topic:   Which OTC pain killers are hepatoxitic?
px1138

Amateur Bodybuilder

Posts: 229
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Registered: Sep 2000

posted February 10, 2001 10:35 AM

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I know acetaminophen is hard on the liver, and i think ibruprofen is too. How about aspirin?

I've got a damn cavity the size of texas in one of my wisdom teeth, only slept 2 hours because of it last night. im on a cycle right now, and im trying to take it easy on the liver...


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slappydog

Amateur Bodybuilder

Posts: 57
From:FL
Registered: Jan 2001

posted February 10, 2001 12:30 PM

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A good question...I too would like to know about this as I am currently on one 17aa oral and would like to take motrin for my shoulder but am worried about the added liver stress.


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px1138

Amateur Bodybuilder

Posts: 229
From:
Registered: Sep 2000

posted February 10, 2001 02:29 PM

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bump


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px1138

Amateur Bodybuilder

Posts: 229
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Registered: Sep 2000

posted February 10, 2001 03:57 PM

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no one?


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E-Toon

Amateur Bodybuilder

Posts: 100
From:Massachusetts
Registered: Jun 2000

posted February 10, 2001 05:04 PM

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Aspirin, Ibufrofen, Naproxen are fine to take. So is Tylenol for that matter.

Tylenol is not particularly hepatotoxic, it's toxic effect after a single oral dose in adults occures at ~10-15 grams... or 20-30 500mg capsules or tablets.

For the FDA to allow OTC drugs to be OTC, the need to fit several criteria and a good safety profile is one of them. If you follow the recommended doses (and warnings on the label) and excercise common sense in terms of your dosage regimen, it is EXTREMELY unlikely to have toxicity with OTC drugs.

I hope this helps,

Toon


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chewbacca

Novice

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Registered: Nov 2000

posted February 10, 2001 05:09 PM

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ANY medicine you take orally that goes through first pass metabolism is to some degree "hepatotoxic". Anything you ingest undergoes processing by the liver. It is an amazing organ to say the least.

17aa gear stresses liver function by inhibiting degradation/metabolism therefore, increasing the half-life of the compound. Remember the does not have a finite # of cells. It is in a constent process of generating new ones. When drugs are introduced into the system at recommended FDA dosages, your liver can metabolize them without too much stress. However, if someone drinks alcohol, tylenol, winny, D-bol and A-50's then your organ would look worse than my moth-eaten sweater passed down from my grandfathers former college roomate. Elevated liver markers such as the P450 enzymes are tell-tale sign of hepatotoxicity. Herbal liver support formulas help a small degree. I think picrorhiza kurroa root extract(active ingredient is usually 4%standardized kutkin) is HIGHLY UNDERATED and IS MORE effective than milk thistle extract(standardized silymarin).

High doses of Aspirin will cause intestinal bleeding.The interesting thing about this drug is that if it had just come up to the FDA for maket approval...it would have never had made it on the pharmacy shelves!
Tylenol should never be taken after a night of drinking. You should always substitute it with Ibuprofen/Advil. I hope this helps...


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slappydog

Amateur Bodybuilder

Posts: 57
From:FL
Registered: Jan 2001

posted February 10, 2001 05:20 PM

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Thanks


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panerai

Pro Bodybuilder

Posts: 578
From:usa
Registered: Nov 2000

posted February 10, 2001 05:35 PM

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Ibuprofen is the safest choice,stick to it.Don't ever take Tylenol,if you use 17-AA.


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chewbacca

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Registered: Nov 2000

posted February 10, 2001 05:38 PM

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ANY medinine you take orally is going to be hepatotoxic to some degree. all drugs you ingest undergoes first-pass metabolism that involves processing by your liver. the liver is an amazing organ consistantly detoxifying harmful substances. Keep in mind that it does not have a finite # of cells. it is in a constant state of generating new cells as old ones die(sometimes as a result of that one that last D-bol tab).

Ingesting tylenol, winny, D-bol, an A-50's would make your liver look worse than my moth-eaten hand-me-down from my grandpa's former roomate from college. Elevated liver markers such as the P450 enzymes are a tell-tale sign of heptotoxicity.

Herbal liver support formulas help to some degree by increasing bile flow. Picroliv the trade name for Picrorhiza kurroa root extract(usually standardized for 4% kutkin-the active ingredient) is HIGHLY UNDERRATED an IS MORE EFFECTIVE than milk thistle extract (usually with standardized silymarin).

Aspirin in high doses will cause G.I. tract (intestinal bleeding). The interesting thing is that if aspirin tried to make it through the FDA drug approval process today...it would have failed miserably!
Always substitute ibuprofen/advil instead of tylenol after a night out drinking with a night out with the boys hookin it up with the hoochies. I hope this helps...
Feel free to email me with any additional questions...


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