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 Best dosaging schedule for Arimidex
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| Author | Topic: Best dosaging schedule for Arimidex | ||
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Pro Bodybuilder 
Posts: 352 |
Here is what I came up with: Desired blood concentrations for peak ant-estrogenic activity is 1mg. This will nullify 98% of all circulating estrogens. The half-life of anastrozole is 48hrs. So, the desire is to maintain blood levels of the drug constantly around 1mg. Anything above that would be a waste of money, Day 1: Take 2mg upon arising(2.0) Day 2: nothing(1.5) Day 3: Take 0.5mg upon arising(1.5) Day 4: Take 0.25mg upon arising(1.375) Day 5: Take 1/4 tab(1.28) Day 6: Take 1/4 tab(1.21) Day 7: Take 1/4 tab(1.14) Day 8: Take 1/4 tab(1.07) Day 9: Take 1/4 tab(1.00) Then keep taking 1/3 tab everyday in order to maintain blood levels of 1mg The brackets denote the blood levels at the end of the given day. Godspeed [This message has been edited by Fonz (edited February 04, 2001).]     | ||
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Amateur Bodybuilder 
Posts: 126 |
Great info Fonz. Bump. | ||
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Amateur Bodybuilder
Posts: 127 |
heck yeah that was cool. ------------------ | ||
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Cool Novice 
Posts: 13 |
That would be a good idea but we do not know if the strength of the pill is equal throughout if i am correct. Also I'm curious how you found out the halflife is 48 hours. | ||
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Elite Bodybuilder 
Posts: 866 |
Hmmm. Thats really helpfull. Thanks. bump for others. ------------------ | ||
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Amateur Bodybuilder
Posts: 115 |
FONZ not trying to start an arguement but wouldn't it be easier to take 1/2 EOD after the initial "loading" phase. I own a pill splitter it is easy to split a pill in half accurately how the hell do you split a pill into four even pieces. What would blood levels look like at 1/2 EOD? Just curious FONZ. | ||
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Pro Bodybuilder
Posts: 352 |
Blakek2 go to the FDA clinical database and check their scientific data on anstrozole. 3CCEOD you are correct. 1/2mg EOD would work just as well after the initial loaing phase Godspeed [This message has been edited by Fonz (edited February 04, 2001).] | ||
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Freak 
Posts: 1989 |
Fonz, you posted this 98% figure earlier today. I am going to go out on a limb here and say that none of the control subjects who were used in the Zeneca study were taking a gram of test a week. These doses are fine for those who are using low doses of 200mg/wk, but if you're taking moderate to high doses you'll need more than what you have laid out there. ------------------ | ||
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Pro Bodybuilder
Posts: 352 |
That is a very good point. Unfortunately there are no studies done on subjects taking 1g test/week. But to theorize, excess test is converted to estrogen via the aromatase enzyme. Now, two things can happen: 1) There is a specific amount of aromatase enzymes in our system. In other words enzyme level is consistent and totally independent of test. levels. In this case, the results the 200mg/week patients saw would be duplicated exactly on a typical bodybuilder using 1g/week. 2) The body increases the number of aromatase enzymes due to the high levels of test. In this case more arimidex would be needed to nullify the extra enzymes. I BUMP this for someone who knows the answer because I certainly don't Godspeed | ||
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Pro Bodybuilder
Posts: 352 |
Bump, because I'm perplexed. Godspeed | ||
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Amateur Bodybuilder
Posts: 117 |
Good topic, very useful. I have just one observation: Isn't it the case that the subjects in the clinical trials received 1 mg every day? If so, then after a few days of this regimen, the plasma concentration of the drug would stabilize at around 3.5 or so mg active. If so, then in order to get the 98% suppression of circulating E, one would need to take the full 1 mg dose daily (and load with 4 mg on day one, if desired.) The other question raised earlier by Ulter, whether or not Arimidex's suppression of aromatization is dependent on the serum concentrations of testosterone, is one the answer to which would be very helpful to know, of course. ------------------ | ||
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Freak
Posts: 1989 |
The reason I raised this question of "how much is enough in the presents of a gram of test" is because if in fact the number of aromatase enzymes was not increased when you add that test then how would your system account for it. In other words, if they didn't increase in number then there wouldn't be enough to aromatize the extra gram of test present, that gram of test would just overwhelm your system, but that is just not the case. As your body seeks homeostasis it would naturally increase the amount of aromatese enzymes in order to create a balance. So you would need at least the amount in the trials or more. ------------------ | ||
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Amateur Bodybuilder
Posts: 52 |
I know Arimidex keeps estorgan low witch = no water retention but does it = more strenght & size? This is what i want to know! | ||
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Pro Bodybuilder
Posts: 384 |
Fonz, excellent post. Ulter, you are 100% correct on that last post; I don't think Fonz was thinking about that... You would need more with more test. If not, test would aromatise the same in high doeses as it does in low doses. And, you should gain better with armidex in your cycle because it keeps more of your test as test. It would make sense. -Stew | ||
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Freak
Posts: 1989 |
Come on Macro.. You're on the board I see you. Can we get a ruling on this?? ------------------ | ||
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Pro Bodybuilder
Posts: 352 |
Ok, I'm back, and I have some partial answers, I'll wait for Macro or Huck to give the full explanation. 1) We are all pretty much in agreement now that the body increases the amount of aromatase enzymes present if test levels go up. 2) But, here is the conundrum: Wasn't anastrozole(arimidex) designed to suppress the production of the aforementioned estrogen-converting enzyme? Having taken into account this last sentence of reasoning, would it matter if the body tried to make new enzymes. I mean the arimidex works at a pre-enzymatic level therefore blocking the production of the last enzyme(e.g. the aromatase enzyme). so, wouldn't an attempted increase by the body to reach homeostasis be futile, due to the fact that the arimidex is not letting our bodies produce the necessary aromatase enzyme? Godspeed | ||
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Elite Bodybuilder
Posts: 1240 |
Anecdotal evidence shows that guys who are doing 1gm or greater of test per week (plus other anabolics/androgens) are doing well with as low as 1/-4-1/3cc EOD. 1/2 cc eod is certainly worth the extra cost if needed IMO. ------------------ |
All times are ET (US) | |
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posted February 04, 2001 04:28 PM