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  reduced sensitivty to juice?

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Author Topic:   reduced sensitivty to juice?
DCS

Cool Novice

Posts: 47
From:
Registered: Jan 2001

posted January 26, 2001 01:02 AM

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Any long time/heavy users out there feel that their sensitivty to roids has been diminished?


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Iron God

Elite Bodybuilder

Posts: 961
From: Parts Unknown
Registered: May 2000

posted January 26, 2001 01:04 AM

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It's not demininshed but once you reach a certain size you take alot more to get alot less.

[This message has been edited by Iron God (edited January 26, 2001).]


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DCS

Cool Novice

Posts: 47
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Registered: Jan 2001

posted January 26, 2001 01:11 AM

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I am starting 6th cycle now. The last one was a huge overdose by my standards. At least my body told me that it was. I had really bad headache, blurry vision, trouble focusing. Now with this 6th cycle I find I don't have the intense feeling of well being I had with the cycles 1 through 4. I actually feel a little dopy. Im worried that the last cycle, the bad overdose one, blew out my receptors or something like that. You think its possible or am I being stupid?


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DCS

Cool Novice

Posts: 47
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Registered: Jan 2001

posted January 26, 2001 01:19 AM

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....


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DCS

Cool Novice

Posts: 47
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Registered: Jan 2001

posted January 26, 2001 01:27 AM

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someone in the know please throw their opinion in here


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Hardcore4Evr

Elite Bodybuilder

Posts: 825
From:Alabama
Registered: Sep 2000

posted January 26, 2001 01:38 AM

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Think about it like this. Most on their first cycles gained large amounts of poundages.....anywhere from 15 to 30. Now, lets say, that every cycle you were on, that you could keep gaining this amount. If this were the case, i dont think Ronnie Coleman would be weighing 300 pounds, but probably 400 instead.
Its crazy, but true. The more you weigh, the harder to gain. Ask any guy who weighs 275 and see what his goals are. Probably to gain around 5 to 10 good pounds of solid mass.......IF they are lucky. Just gotta keep trying, and you will succeed.

------------------
"If you believe in yourself & have dedication & pride, and never quit, you'll be a winner. The price of victory is high, but so are the rewards."
-Paul "Bear" Bryant, Alabama Crimson Tide

EMAIL: [email protected]


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DCS

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posted January 26, 2001 01:45 AM

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I understand the weight thing but Im talking about the brain here. Could I have friedd the brain cells that give you the good feelings from roids?


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DCS

Cool Novice

Posts: 47
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Registered: Jan 2001

posted January 26, 2001 01:49 AM

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Im asking if any of you long time heavy users still get the endorphin rush from the juice or if you've found its diminished over time


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DCS

Cool Novice

Posts: 47
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Registered: Jan 2001

posted January 26, 2001 02:07 AM

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could someone at least tell me I m wrong? Or that they don't know? Or that I might be right? Its actually an important issue.

Also what does anyone think about this cycle-I've started...
500mg test enantate weekly (week 1-4)
100mg Masteron every three days (week 2-3)
1-2tabs Arimidex daily

I haven't hit the masteron yet. Its expensive and I want everything else to be going weel before I use it. Its the first itme I ever got Masteron. Some say its the same as test, others say it gets them super duper hard. Opinions?


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macrophage69alpha

Moderator

Posts: 1595
From:San diego, CA
Registered: Jan 2000

posted January 26, 2001 02:15 AM

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too much arimidex
some estrogen is necessary for proper brain function
2 tabs of arimidex at that dosage is OVERKILL
1/2 tab eod or even 1/3-1/4 tab eod should be enough

------------------
MP



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DCS

Cool Novice

Posts: 47
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Registered: Jan 2001

posted January 26, 2001 02:20 AM

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hmmmm... for some reason I didnt think of that. That might indeed be why Im not feeling well. Its actually the first time Ive used this much. Thanks alot


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ironmaster

Pro Bodybuilder

Posts: 597
From:
Registered: Apr 2000

posted January 26, 2001 03:11 AM

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Anti-estrogens make you feel shitty in general. That is a light cycle, you sure don't need that much. On those doses, I would just keep some around in case the need arose.


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DCS

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Registered: Jan 2001

posted January 26, 2001 03:31 AM

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Talk of antiestrogens asidde what do you think would happen if someone injected say something rediculous like 1000mg test suspension. IF the guy didn't duy that would have to cause some permanent damage wouldn't you think. Test levels would be something like 500 - 5000 times normal levels.


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*B*

Amateur Bodybuilder

Posts: 280
From:USA
Registered: Jun 2000

posted January 26, 2001 04:17 AM

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I think that you will find that quite a few bros on this board go with 1 g of test a week (rediculous?). And of course using anti-e's is a must with that amount of test. I know that is what I am probably going to go with on my next cycle...... "B"


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Stew Meat

Pro Bodybuilder

Posts: 328
From:Louisiana
Registered: Jul 2000

posted January 26, 2001 04:49 AM

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There's a big difference in 1000g of test. and 1000g of test suspension. Test suspension has no ester so all is released at the same time. You system would probably go into shock. You would probably have a massive heart attack.

As far as your other subject:
To my knowlege no evidence has supported receptor downregulation from repeated steroid use but, the theroy is still in existance.
You will, however, recieve less benefit over time. Just as an alcoholic can drink more beer and not get drunk, the liver of the repeated steroid user becomes more efficient at metabolising androgens.
I support Macrophage 100% on his answer. You problem most probably lies in your Armidex.
Also, Hardcore is right. What the androgen receptor's purpose is in life is to instruct via mRNA the transcription of the Myosin gene. This gene is responsible for the assemblage of contractile proteins within the muscle fiber. The more dense the layer of contractile molecules, the greater the muscle size, and the greater the resistence is in contractile protein production. Here's where genetics come into play. The Myosin gene may contain genetic instructions to accept feedback from contractile protein density or may contain instructions to continue construction of the proteins anyway (construction in ribosomes). Regardless, the more dense the contractile proteins in muscle fibers, the less chance you have of additional manufactoring. Hence, genetic limits in muscular growth.


-Stew


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DCS

Cool Novice

Posts: 47
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Registered: Jan 2001

posted January 26, 2001 05:26 AM

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Im still up...too much andrgoen receptor activity working in my bod I guess. Oh well at least I get my ambien today. I 'll rough it out and crash early.

I appreciate your response stew. One idea is that actual DNA/mRNA could be damaged from super high hormonal concentrations. They could cause tears in the DNA strands. This doesn't have much to do with receptor upregulation or downregulation.


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2Thick

Moderator

Posts: 6253
From:Me, To You
Registered: Jun 2000

posted January 26, 2001 01:23 PM

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I would advise 6 months off while you re-evaluate your goals and focus on the joys of natural weight training.

You will come back refreshed!


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Stew Meat

Pro Bodybuilder

Posts: 328
From:Louisiana
Registered: Jul 2000

posted January 26, 2001 03:34 PM

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High anabolic hormone concentrations will not cause damage to DNA/. Some hormones actually increase mRNA transcription (make more). mRNA is what is transcripted from the myolen gene to tell the ribosomes to begin construction of additional contractile proteins. The androgens have nothing to do with nucleaic acids directly.

-Stew


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Stew Meat

Pro Bodybuilder

Posts: 328
From:Louisiana
Registered: Jul 2000

posted January 26, 2001 10:57 PM

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bump


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