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First, I have taken 100mgs/dose without problems. I simply love A50, and A50 loves me. Unfortunately, for the very large majority of the people, the receptor affinity of anadrol will be VERY low. This is the sole reason the drug is produced in 50mg only strength. Sure, you may find some smaller dosages out there, but how common or popular are they?

Now then, the people who stand against A50 will piont out that it will very rapidly convert into other compounds, which might quickly lead to gyno, massive H20 retention, hair lose, and acne. However, this will only occur in those whom are -

A) Predisposed to MPB, and fat storage around the chest region.
B) With very low receptor affinity to the drug, as well as low receptor population.

I personally would not use under 50mgs a dose. Some people say it will be best used in smaller quantities over time, due to less overall conversion. However, this is largely misconception. The drug does not instantly convert because there's 50mgs of it around. Think about it, how many people get gyno from 75mgs of testosterone propinate a day, or better yet, 50mgs of suspension a day? Very few. The reason for the drugs rapid conversion is as stated above, low receptor affinity and population, leading to the free floating levels of the drug to be higher, and anything in the human metabolism will eventually get used or converted for another purpose, if not simply destroyed by the body immune system.

Basicly, the safety of the drug is completely dependant on the user, when refering to side effects. I have used over 300mgs/day, no nolvadex, and not gained much water at all. I personally believe this is due to my personal genetic receptor shaping and population being exceptionally avaliable to uptake the chemical. However, if you are subject to MPB, acne, gyno, and what not, using smaller doses may not be a terrible idea. Unfortunately, you will still have a low receptor affinity to the drug, which is not dependant on the dosage at all. If you react that badly to A50, I would simply stay away, and leave it for the freak shows of the human race (like myself) which can use the drug without problems. We are the VERY SMALL minority in this case, but I have bumped into a couple people over time that haven't had problems with super dosages.