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Little Rage
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Mavy:
regarding your original question: I agree to what you said in an older post. i don't feel this is a market for it: there are other similar drugs to it (nandrolone and primo). and i don't think the reason that it increase hunger would be a reason to use it for humans, b/c hey that's a myth too
Regarding the anxiety issue:
i completely agree that with many it is a placebo effect, but there are the cases of people having no previous knowledge of a possible increase of anxiety with its usage; and it does affect these people.
There have been reports of people getting anxiety from other substances too, such as tren and even test. Now it could be due to previous anxiety problems, a placebo effect, or just attributed to events causing anxiety in their life.
I personally have noticed an increase in anxiety with just about every type of gear i have used: though to different degrees. I have had anxiety problems before i started to use gear and it has continued while off cycle. I was ready for a slight increase in anxiety with eq, but it put me in a complete wreck at times. Then i tried tren, i was ready for anxiety to knock me on my ass b/c of its anxiety myths. However i experienced 0 to minimal increase in anxiety, and 2 bad attacks lasting about 5min. when i was on eq, my anxiety attacks lasted up to 1:30 HOURS!!! Now i'm not ignorant and won't deny that some of my anxiety is due to personal reasons and such, but i have never had an anxiety attack lasting over 15min or so. And when on eq, an attack of 45min-1hr was not uncommon. They were even in the range of 6-12 a week (i believe i had 15 in 3 days).
I came across your original post on this: fukkenshredded added his insight to this:
"EQ stimulates erythropoiesis, which can lead to high BP very quickly and anxiety can result from this alone.
Increased blood volume explains both anxiety as well as increased appetite. Its not across the board, but will affect many this way more often than not."
I also came across this study from a previous post:
Although the study does not deal with EQ specifically, I would be surprised if it did not have the same anxiety inducing effects as the other drugs.
It is also thought that anabolic steroids also act on the body's natural opioid system to somehow induce anxiety and aggressiveness.
The abstract shows that certain anabolic steroids increase the metabolism of serotinin, leading to low levels of serotonin in the body. This could be responsible for the anxiety felt by many steroid users, as well as for "roid rage" ( I personally think that a jerk will remain a jerk, and a mellow person will remain mellow on steroids.) It is particularly interesting that anadrol was the only agent to raise monamine oxidase levels. This is a key enzyme responsible for metabolizing serotonin. Anandrol is notorious for increasing aggression.
Br J Pharmacol 1999 Mar;126(6):1301-6
Increased dopaminergic and 5-hydroxytryptaminergic activities in male rat brain following long-term treatment with anabolic androgenic steroids.
Thiblin I, Finn A, Ross SB, Stenfors C.
Department of Forensic Medicine, Karolinska Institute, Stockholm, Sweden.
1. The effects of treating groups of rats with four different anabolic androgenic steroids (AAS) (testosterone, nandrolone methandrostenolone, and oxymetholone) on 5hydroxytryptamine (5-HT) and dopamine (DA) neurones in different brain regions were examined. The AAS was injected six times with 1 week's interval and the rats were sacrificed 2 days after the final injection. 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA), DA and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were measured. The effect on DA and 5-HT synthesis rate was analysed as the accumulation of 3,4-dihydroxyphenyl-alanine (DOPA) and 5-hydroxytryptophan (5-HTP), respectively, after inhibition of the amino acid
decarboxylase with NSD-1015 (3-hydroxy-benzylhydrazine dihydrochloride). Additionally, the monoamine oxidase (MAO) activity was analysed in the hypothalamus. 2. The DOPAC + HVA/DA ratio was increased in the striatum in all treatment groups. However, the synthesis rate of DA was significantly increased only in the methandrostenolone treated group. 3. The 5-HIAA/5-HT ratio was increased in all treatment groups in the hippocampus, in the frontal cortex in the methandrostenolone-treated animals and in the hypothalamus in the testosterone- and oxymetholone-treated rats, while the 5-HT synthesis rate was not affected by the AAS-treatments. 4. The MAO-A activity was increased in the oxymetholone-treated rats while the other treatment groups were unaffected. The MAO-B activity was not changed. 5. The results indicate that relatively high doses of AAS increase dopaminergic and 5-hydroxytryptaminergic metabolism in male rat brain, probably due to enhanced turnover in these monaminergic systems
Anyway you look at it, I don't think we will have a definite explanation of this for a long time... if ever.
regarding your original question: I agree to what you said in an older post. i don't feel this is a market for it: there are other similar drugs to it (nandrolone and primo). and i don't think the reason that it increase hunger would be a reason to use it for humans, b/c hey that's a myth too
Regarding the anxiety issue:
i completely agree that with many it is a placebo effect, but there are the cases of people having no previous knowledge of a possible increase of anxiety with its usage; and it does affect these people.
There have been reports of people getting anxiety from other substances too, such as tren and even test. Now it could be due to previous anxiety problems, a placebo effect, or just attributed to events causing anxiety in their life.
I personally have noticed an increase in anxiety with just about every type of gear i have used: though to different degrees. I have had anxiety problems before i started to use gear and it has continued while off cycle. I was ready for a slight increase in anxiety with eq, but it put me in a complete wreck at times. Then i tried tren, i was ready for anxiety to knock me on my ass b/c of its anxiety myths. However i experienced 0 to minimal increase in anxiety, and 2 bad attacks lasting about 5min. when i was on eq, my anxiety attacks lasted up to 1:30 HOURS!!! Now i'm not ignorant and won't deny that some of my anxiety is due to personal reasons and such, but i have never had an anxiety attack lasting over 15min or so. And when on eq, an attack of 45min-1hr was not uncommon. They were even in the range of 6-12 a week (i believe i had 15 in 3 days).
I came across your original post on this: fukkenshredded added his insight to this:
"EQ stimulates erythropoiesis, which can lead to high BP very quickly and anxiety can result from this alone.
Increased blood volume explains both anxiety as well as increased appetite. Its not across the board, but will affect many this way more often than not."
I also came across this study from a previous post:
Although the study does not deal with EQ specifically, I would be surprised if it did not have the same anxiety inducing effects as the other drugs.
It is also thought that anabolic steroids also act on the body's natural opioid system to somehow induce anxiety and aggressiveness.
The abstract shows that certain anabolic steroids increase the metabolism of serotinin, leading to low levels of serotonin in the body. This could be responsible for the anxiety felt by many steroid users, as well as for "roid rage" ( I personally think that a jerk will remain a jerk, and a mellow person will remain mellow on steroids.) It is particularly interesting that anadrol was the only agent to raise monamine oxidase levels. This is a key enzyme responsible for metabolizing serotonin. Anandrol is notorious for increasing aggression.
Br J Pharmacol 1999 Mar;126(6):1301-6
Increased dopaminergic and 5-hydroxytryptaminergic activities in male rat brain following long-term treatment with anabolic androgenic steroids.
Thiblin I, Finn A, Ross SB, Stenfors C.
Department of Forensic Medicine, Karolinska Institute, Stockholm, Sweden.
1. The effects of treating groups of rats with four different anabolic androgenic steroids (AAS) (testosterone, nandrolone methandrostenolone, and oxymetholone) on 5hydroxytryptamine (5-HT) and dopamine (DA) neurones in different brain regions were examined. The AAS was injected six times with 1 week's interval and the rats were sacrificed 2 days after the final injection. 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA), DA and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were measured. The effect on DA and 5-HT synthesis rate was analysed as the accumulation of 3,4-dihydroxyphenyl-alanine (DOPA) and 5-hydroxytryptophan (5-HTP), respectively, after inhibition of the amino acid
decarboxylase with NSD-1015 (3-hydroxy-benzylhydrazine dihydrochloride). Additionally, the monoamine oxidase (MAO) activity was analysed in the hypothalamus. 2. The DOPAC + HVA/DA ratio was increased in the striatum in all treatment groups. However, the synthesis rate of DA was significantly increased only in the methandrostenolone treated group. 3. The 5-HIAA/5-HT ratio was increased in all treatment groups in the hippocampus, in the frontal cortex in the methandrostenolone-treated animals and in the hypothalamus in the testosterone- and oxymetholone-treated rats, while the 5-HT synthesis rate was not affected by the AAS-treatments. 4. The MAO-A activity was increased in the oxymetholone-treated rats while the other treatment groups were unaffected. The MAO-B activity was not changed. 5. The results indicate that relatively high doses of AAS increase dopaminergic and 5-hydroxytryptaminergic metabolism in male rat brain, probably due to enhanced turnover in these monaminergic systems
Anyway you look at it, I don't think we will have a definite explanation of this for a long time... if ever.
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