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Don't take huuuuuge amounts of vitamin C at a time !
Dr. Levine and his colleagues have found that the body's absorption of orally ingested vitamin C decreases as the dose increases.
Thus while 80 per cent of a 100 mg dose is fully absorbed less than 50 per cent of a 1250 mg dose is actually absorbed.
Dr. Levine concludes that doses greater than 500 mg contribute little to plasma or tissue stores. He also estimates that even at doses of 1000 mg it is extremely difficult to achieve a blood plasma concentration much above 100 micromol/L.
Intravenous infusions, on the other hand, can achieve plasma levels as high as 5000 micromol/L with a dose of 5 to 10 grams.
Padayatty, Sebastian J. and Mark Levine. New insights into the
physiology and pharmacology of vitamin C. Canadian Medical Association Journal, Vol. 164, February 6, 2001, pp. 353-55 Hoffer, L. John.
Dr. Levine and his colleagues have found that the body's absorption of orally ingested vitamin C decreases as the dose increases.
Thus while 80 per cent of a 100 mg dose is fully absorbed less than 50 per cent of a 1250 mg dose is actually absorbed.
Dr. Levine concludes that doses greater than 500 mg contribute little to plasma or tissue stores. He also estimates that even at doses of 1000 mg it is extremely difficult to achieve a blood plasma concentration much above 100 micromol/L.
Intravenous infusions, on the other hand, can achieve plasma levels as high as 5000 micromol/L with a dose of 5 to 10 grams.
Padayatty, Sebastian J. and Mark Levine. New insights into the
physiology and pharmacology of vitamin C. Canadian Medical Association Journal, Vol. 164, February 6, 2001, pp. 353-55 Hoffer, L. John.
