i cant remember how long it took to kick in, but accutane is fucking gnarly. its so liver toxic its ridiculous. pregnant women arent even allowed to touch the pills because of possible birth defects. ill never use that shit again. nose bleeds, dry lips, sensitvity to the sun. also made my skin so sensitive that when i wrestled, afterward my face would be so scraped up it looked like i got jumped. dont use unless absolutely nessesary. my .02