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The Luteinizing hormone and HCG: Distinguishing the unique physiologic roles
June 2018 By Vision PuritySourceLabs.ru
If you're reading this chances are you're researching PED's, there abilities and the enhancement effects for recovery,
I'm going to speculate that you may already have heard of HCG by now - (human chorionic gonadotropin)
Let's discuss what it is, and it's potentials with recovery and raising testosterone?
The most basic and common literature available with HCG human chorionic gonadotropin (hCG) & Luteinizing hormone (LH) are that they both are integral components of the hypothalamic–pituitary–gonadal axis, thus this untimely controls the capability of an organism to reproduce and functionality HCG is what synthetic testosterone is to natural testosterone only mimics luteinizing hormone. Luteinizing hormone is a hormone produced by gonadotropic cells in the anterior pituitary gland also most regularly referred to as “LH” is the hormone that signals the testes to produce testosterone.
So why is HCG mot commonly used during a PCT or even during a cycle?
Some major factors rest on the properties that that it may hinder and ultimately minimize the amount of testicular shrinkage during AAS intake or after..
There's a complex interplay in which HCG sends a signal to gonads to try and achieve optimal LH output or signaling at least!
However if and when in the event that you decide to discontinuation the treatment/usage of testosterone "the exogenous hormone" you posses what is known as secondary hypogonadism and/or "PRIMARY" hypogonadism.
What is this Primary hypogonadism to be exact?
This is a last ditch effort or a cascade of events with metabolites, most importantly this will take place when the pituitary gland or hypothalamus when there's a signals/seizes manufacturing of testosterone or decreasing in a great amount, in fact in almost all cases 75-100% hindrance!
Therefore to implement the use of HCG in such instances is pivotal intended to help achieve LH levels to possible restore or function back to a healthy and stable producing enlivenment on you're own, of course with the assistance, and sometimes multiple applications is necessary, but blood work will indicate if that is important..
Right about now your most likely asking yourself exactly "How effective is HCG and is it for me"?
This has been a cloaked topic over the years with regurgitated bro-science vs real actual clinical findings, and over the years specialists have emphasize the truth of an assertion or importance, especially one contrary to what might be expected or what has been asserted by others to be misleading, supporting real actual therapeutic advantages, while others claim it to not be necessary (in some instances that holds some truth, but this is not a one size firs all way of life).. Doses and protocols will vary from one to the next, the kinetic profile under clinical investigation/studies shown administration with certain dosages may yield different toxicological profiles for the same users, some reaching supraphysiological serum testosterone levels and some reaching within the gold standard text book parameters, but this will vary with administered route
Some fast take home notes:Whether IM or sub-Q and individual-sensitivities, age, genetics and metabolites that are presence and the cascade of events that transpire with signaling, activation and deactivation of transcelluar groups will all yield different results, keep in mind that all HORMONES are "chemical messengers" that relay messages to cells that display specific receptors for each hormone and respond to the signaling..individual metabolization ratio with the hormone can/may make changes directly to a cell, by changing the genes that are activated, or by making changes indirectly to a cell by stimulating other signaling pathways inside a specific cell group that is effected and effect other processes, thus this can "initiate" an intracellular cascade of events.
How do I know what dosages is for me?
First and foremost, one must ask themselves or through prior AAS experiences knowing if they possess a greater affinity with the aromatase enzyme, in which this converts the estrogen ratio into circulation, as HCG can induce elevated estrogen..Starting at 250ius x 2 a week is MORE than sufficient in most cases and can/will avoid destination with greater response, and less chances of a shift in estrogen..Bare in mind that HCG is just as detrimental as AAS with elivating estrogen levels,and it can activate the ER/PR receptors inducing glandular duct agitation and activation causing gynocomastia thus it's pivotal and highly suggested to utilize AI's (aromatsa inhibators) to suppress the conversion ratio while providing the effects with desired added advantage to continue his treatment to stimulate LH and Testosterone production without the interference or fear of activating ER's or experiences estrogen side effects..Using a serm such as Tamoxifen is ideal and a great lock and key method type binding agent for the ER's as a agonists and antagonists..
Baseline bloods, pre-prior and post is a great indicator to keep personal notes on where you were, where you went and where you may be heading and if you in fact fully recovered!
Added bonus: For those that may experience a sudden loss in libido during cycle or blast - HCG can temporarily increase almost anyone's libido. However, after your body gets adjusts to HCG or you decrease or cease your dosage, the glands that produce testosterone are no longer stimulated, therefore utilizing it for this particular reason should be done with intervals, blast and repeat when need..Low dose 250ius can achieve almost dramatic effects for anyone, and some report libido stimulation last or staying recovered for long durations.
Mixing Euro-Peptides HCG with this instructions you will have the best directions on how to reconstitute HCG.
Add 2ml of bac water to a 5000 (lyophilized powder)unit vial of HCG..Keep in mind if you use a slin pin the 10 mark on a slin pin will give you 250 ius
In order to assure greater quality and product efficiency, EP would like to point out some crucial principals in regards with reconstituting Euro-Pharmacies/Peptides HCH and other "lyophilized powders"
If by chance you are reading this you might already have interests in Euro-Pharmacies "Euro-Peptides HCG", or your seeking information with how to reconstitute EP's HCG and you are about to begin the process..Stop!
Please read here as EP would like to assure greater quality with its products,so you can achieve greater success and reap your just rewards though the positive benefits of Euro-Peptides HCG ,by utilizing the preferred method suggested
Whether your a seasoned Vet or just doing research, it's crucial that you know about HCG and the several typed of water utilized for reconstitution of the hormone..
Let's start with the standard by naming a few shall we?
The first one comes to mind with notoriety would be Bacteriostatic water (0.9% sodium chloride), this is most commonly used aside from Plain sterile water (we will cover that in a moment)..Its one of the most favored methods, and recommend principles to achieve greater stability due to pH levels in the Bac, and the slight preservative properties of the sodium chloride..Euro-pharmacies supplies a 1mL ampule of Bacteriostatic water (0.9% sodium chloride) due to the friendly nature it possess with easily degradable compounds such as peptides/proteins/aa's, as it is slightly acidic pH value of 5.5 for optimal protein and peptide stability, this eliminates the need to use acetic acid solutions,which often causes inconvenience handling peptides.. This diluent allows multiple-use..Highly suggested for all peptide/HCG use..Degradation is not a factor or a concern, making this a peptide friendly diluent.
Plain sterile wateris next in line as a recognized and common practice for reconstitution of peptides, as it can be easily purchased in some regions, and/or simple to manufacture under the appropriate conditions with some know-how..Unfortunately enough, this method fails to yield the advantage of providing a shelf life for peptides..Sterile water should only be considered when a single use is desired such as 10mL within 24hrs due to the fact that it does not posses any agents to mitigate bacterial growth,because it fails to provide any antimicrobial properties, this should be utilized for singular-usage (within 24hrs if peptide has been stored in 36-46 degrees Fahrenheit or 2-6 degrees centigrade).
Bacteriostic water (0.9% benzyl alcohol 9mg/mL) is one of the most controversial diluents out there,many swear by it advocating its properties to extended shelf life because of its clinical/treatment preservative properties..Unbeknownst to many, this is quite possibly the worst agent to consider when reconstituting peptides, because it can create an unstable environment within the protein molecules.. Because of the antimicrobial preservatives in Benzyl Alcohol it accelerates the aggregation of protein molecules..By introducing Ba with it's increasing antimicrobial preservative levels it increases the hydrophobicity of a formulation by effecting the proteins aqueous solubility,considerably destabilization of the proteins (degradation of the aa's)..Because of the physical and chemical manipulation during the reconstitution/storage process as this can happen during every step, formulation aggregation of proteins is almost certain where at some point protein molecules will align and unfold, exposing their hydrophobic regions for charged-based association (BA,shaking,long term-moderate storage,stirring and shearing),agitation induces aggregation is almost certain within the proteins minimizing efficiency (this applies for all peptides,HCG, AND hgh orhemoglobin,and insulin)..This reconstitution method should not be considered under any circumstance,this is critical to preventing significant loss
HCG mixing (reconstitution) instruction:
Remove the plastic cap/flip top carefully from the top of the Euro-Peptide HCG vial/or peptides and clean the rubber-stopper with a medical alcohol pad/swab...
Take Bacteriostatic water (0.9% sodium chloride)Ampule and utilize a pen cap to snap the neck off (this assures a clean/crisp brake)..If you do NOT receive an ample but rather a Euro-Pharmacies 2mL vial of bac, use the same fashion as stated prior with opening flip tops.
Take a NEW syringe and pull the full amount of 2mL from the ampule/vial into the pin.
Note: regardless of how much water you use (be it 1ml or 2ml) the mixture still has the same overall strength, you'll just need to adjust the dosages accordingly, Water is just a transport vehicle method for the peptides, HCG.
You now have 2ml of water in the syringe. Push the needle through the rubber cap of the Euro-HCG vial, but position it sideways so that the water will slide down the inside wall of the vial SLOWLY... Do not inject directly into the powder with force, rather let the water slide out SLOWLY...Majority of the white powder will dissolve within seconds, but there will be some lumps left over. Do not shake the vial in an attempt to get them to dissolve. If you are in a hurry, you can gently roll the vial between your fingers. If you do this for a few minutes all of the powder will dissolve. Alternatively you can let the vial sit in the refrigerator for 15 - 30 minutes.
By that time the HCG (lyophilized powder) will dissolve completely..Before pulling the liquid HCG into the insulin syringe, give the vial a few turns between your fingers to gently mix the solution. The HCG vials are under vacuum (negative air pressure) which makes it harder to pull the liquid out. To relieve the vacuum inject a full syringe of air into the top of the vial (do not make the liquid bubble).You know have reconstituted Euro-Pharmacies HCG.. Same protocol can apply for all peps and HGH, dose depending!
Below is a MS/LC testing essay lab report regarding EP HCG
All testing from 3rd party: Janoshik "[email protected]"
To get your balls back, click below!
June 2018 By Vision PuritySourceLabs.ru
If you're reading this chances are you're researching PED's, there abilities and the enhancement effects for recovery,
I'm going to speculate that you may already have heard of HCG by now - (human chorionic gonadotropin)
Let's discuss what it is, and it's potentials with recovery and raising testosterone?
The most basic and common literature available with HCG human chorionic gonadotropin (hCG) & Luteinizing hormone (LH) are that they both are integral components of the hypothalamic–pituitary–gonadal axis, thus this untimely controls the capability of an organism to reproduce and functionality HCG is what synthetic testosterone is to natural testosterone only mimics luteinizing hormone. Luteinizing hormone is a hormone produced by gonadotropic cells in the anterior pituitary gland also most regularly referred to as “LH” is the hormone that signals the testes to produce testosterone.
So why is HCG mot commonly used during a PCT or even during a cycle?
Some major factors rest on the properties that that it may hinder and ultimately minimize the amount of testicular shrinkage during AAS intake or after..
There's a complex interplay in which HCG sends a signal to gonads to try and achieve optimal LH output or signaling at least!
However if and when in the event that you decide to discontinuation the treatment/usage of testosterone "the exogenous hormone" you posses what is known as secondary hypogonadism and/or "PRIMARY" hypogonadism.
What is this Primary hypogonadism to be exact?
This is a last ditch effort or a cascade of events with metabolites, most importantly this will take place when the pituitary gland or hypothalamus when there's a signals/seizes manufacturing of testosterone or decreasing in a great amount, in fact in almost all cases 75-100% hindrance!
Therefore to implement the use of HCG in such instances is pivotal intended to help achieve LH levels to possible restore or function back to a healthy and stable producing enlivenment on you're own, of course with the assistance, and sometimes multiple applications is necessary, but blood work will indicate if that is important..
Right about now your most likely asking yourself exactly "How effective is HCG and is it for me"?
This has been a cloaked topic over the years with regurgitated bro-science vs real actual clinical findings, and over the years specialists have emphasize the truth of an assertion or importance, especially one contrary to what might be expected or what has been asserted by others to be misleading, supporting real actual therapeutic advantages, while others claim it to not be necessary (in some instances that holds some truth, but this is not a one size firs all way of life).. Doses and protocols will vary from one to the next, the kinetic profile under clinical investigation/studies shown administration with certain dosages may yield different toxicological profiles for the same users, some reaching supraphysiological serum testosterone levels and some reaching within the gold standard text book parameters, but this will vary with administered route
Some fast take home notes:Whether IM or sub-Q and individual-sensitivities, age, genetics and metabolites that are presence and the cascade of events that transpire with signaling, activation and deactivation of transcelluar groups will all yield different results, keep in mind that all HORMONES are "chemical messengers" that relay messages to cells that display specific receptors for each hormone and respond to the signaling..individual metabolization ratio with the hormone can/may make changes directly to a cell, by changing the genes that are activated, or by making changes indirectly to a cell by stimulating other signaling pathways inside a specific cell group that is effected and effect other processes, thus this can "initiate" an intracellular cascade of events.
How do I know what dosages is for me?
First and foremost, one must ask themselves or through prior AAS experiences knowing if they possess a greater affinity with the aromatase enzyme, in which this converts the estrogen ratio into circulation, as HCG can induce elevated estrogen..Starting at 250ius x 2 a week is MORE than sufficient in most cases and can/will avoid destination with greater response, and less chances of a shift in estrogen..Bare in mind that HCG is just as detrimental as AAS with elivating estrogen levels,and it can activate the ER/PR receptors inducing glandular duct agitation and activation causing gynocomastia thus it's pivotal and highly suggested to utilize AI's (aromatsa inhibators) to suppress the conversion ratio while providing the effects with desired added advantage to continue his treatment to stimulate LH and Testosterone production without the interference or fear of activating ER's or experiences estrogen side effects..Using a serm such as Tamoxifen is ideal and a great lock and key method type binding agent for the ER's as a agonists and antagonists..
Baseline bloods, pre-prior and post is a great indicator to keep personal notes on where you were, where you went and where you may be heading and if you in fact fully recovered!
Added bonus: For those that may experience a sudden loss in libido during cycle or blast - HCG can temporarily increase almost anyone's libido. However, after your body gets adjusts to HCG or you decrease or cease your dosage, the glands that produce testosterone are no longer stimulated, therefore utilizing it for this particular reason should be done with intervals, blast and repeat when need..Low dose 250ius can achieve almost dramatic effects for anyone, and some report libido stimulation last or staying recovered for long durations.
Mixing Euro-Peptides HCG with this instructions you will have the best directions on how to reconstitute HCG.
Add 2ml of bac water to a 5000 (lyophilized powder)unit vial of HCG..Keep in mind if you use a slin pin the 10 mark on a slin pin will give you 250 ius
In order to assure greater quality and product efficiency, EP would like to point out some crucial principals in regards with reconstituting Euro-Pharmacies/Peptides HCH and other "lyophilized powders"
If by chance you are reading this you might already have interests in Euro-Pharmacies "Euro-Peptides HCG", or your seeking information with how to reconstitute EP's HCG and you are about to begin the process..Stop!
Please read here as EP would like to assure greater quality with its products,so you can achieve greater success and reap your just rewards though the positive benefits of Euro-Peptides HCG ,by utilizing the preferred method suggested
Whether your a seasoned Vet or just doing research, it's crucial that you know about HCG and the several typed of water utilized for reconstitution of the hormone..
Let's start with the standard by naming a few shall we?
The first one comes to mind with notoriety would be Bacteriostatic water (0.9% sodium chloride), this is most commonly used aside from Plain sterile water (we will cover that in a moment)..Its one of the most favored methods, and recommend principles to achieve greater stability due to pH levels in the Bac, and the slight preservative properties of the sodium chloride..Euro-pharmacies supplies a 1mL ampule of Bacteriostatic water (0.9% sodium chloride) due to the friendly nature it possess with easily degradable compounds such as peptides/proteins/aa's, as it is slightly acidic pH value of 5.5 for optimal protein and peptide stability, this eliminates the need to use acetic acid solutions,which often causes inconvenience handling peptides.. This diluent allows multiple-use..Highly suggested for all peptide/HCG use..Degradation is not a factor or a concern, making this a peptide friendly diluent.
Plain sterile wateris next in line as a recognized and common practice for reconstitution of peptides, as it can be easily purchased in some regions, and/or simple to manufacture under the appropriate conditions with some know-how..Unfortunately enough, this method fails to yield the advantage of providing a shelf life for peptides..Sterile water should only be considered when a single use is desired such as 10mL within 24hrs due to the fact that it does not posses any agents to mitigate bacterial growth,because it fails to provide any antimicrobial properties, this should be utilized for singular-usage (within 24hrs if peptide has been stored in 36-46 degrees Fahrenheit or 2-6 degrees centigrade).
Bacteriostic water (0.9% benzyl alcohol 9mg/mL) is one of the most controversial diluents out there,many swear by it advocating its properties to extended shelf life because of its clinical/treatment preservative properties..Unbeknownst to many, this is quite possibly the worst agent to consider when reconstituting peptides, because it can create an unstable environment within the protein molecules.. Because of the antimicrobial preservatives in Benzyl Alcohol it accelerates the aggregation of protein molecules..By introducing Ba with it's increasing antimicrobial preservative levels it increases the hydrophobicity of a formulation by effecting the proteins aqueous solubility,considerably destabilization of the proteins (degradation of the aa's)..Because of the physical and chemical manipulation during the reconstitution/storage process as this can happen during every step, formulation aggregation of proteins is almost certain where at some point protein molecules will align and unfold, exposing their hydrophobic regions for charged-based association (BA,shaking,long term-moderate storage,stirring and shearing),agitation induces aggregation is almost certain within the proteins minimizing efficiency (this applies for all peptides,HCG, AND hgh orhemoglobin,and insulin)..This reconstitution method should not be considered under any circumstance,this is critical to preventing significant loss
HCG mixing (reconstitution) instruction:
Remove the plastic cap/flip top carefully from the top of the Euro-Peptide HCG vial/or peptides and clean the rubber-stopper with a medical alcohol pad/swab...
Take Bacteriostatic water (0.9% sodium chloride)Ampule and utilize a pen cap to snap the neck off (this assures a clean/crisp brake)..If you do NOT receive an ample but rather a Euro-Pharmacies 2mL vial of bac, use the same fashion as stated prior with opening flip tops.
Take a NEW syringe and pull the full amount of 2mL from the ampule/vial into the pin.
Note: regardless of how much water you use (be it 1ml or 2ml) the mixture still has the same overall strength, you'll just need to adjust the dosages accordingly, Water is just a transport vehicle method for the peptides, HCG.
You now have 2ml of water in the syringe. Push the needle through the rubber cap of the Euro-HCG vial, but position it sideways so that the water will slide down the inside wall of the vial SLOWLY... Do not inject directly into the powder with force, rather let the water slide out SLOWLY...Majority of the white powder will dissolve within seconds, but there will be some lumps left over. Do not shake the vial in an attempt to get them to dissolve. If you are in a hurry, you can gently roll the vial between your fingers. If you do this for a few minutes all of the powder will dissolve. Alternatively you can let the vial sit in the refrigerator for 15 - 30 minutes.
By that time the HCG (lyophilized powder) will dissolve completely..Before pulling the liquid HCG into the insulin syringe, give the vial a few turns between your fingers to gently mix the solution. The HCG vials are under vacuum (negative air pressure) which makes it harder to pull the liquid out. To relieve the vacuum inject a full syringe of air into the top of the vial (do not make the liquid bubble).You know have reconstituted Euro-Pharmacies HCG.. Same protocol can apply for all peps and HGH, dose depending!
Below is a MS/LC testing essay lab report regarding EP HCG
All testing from 3rd party: Janoshik "[email protected]"
To get your balls back, click below!
