mundiiiiiiii!!!!
se te extrañaba por aca..
J Appl Toxicol. 2004 Jan-Feb;24(1):21-6. Related Articles, Links
Protective effect of alpha-lipoic acid against chloroquine-induced hepatotoxicity in rats.
Pari L, Murugavel P.
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu 608 002, India.
[email protected]
Oral administration of a-lipoic acid, a metavitamin, was investigated for its possible hepatoprotective effect in Wistar rats against chloroquine-induced toxicity. Rats were treated orally with alpha-lipoic acid (10, 30 and 100 mg x kg(-1) day(-1)) for 7 days before a single oral administration of chloroquine (970 mg x kg(-1) day(-1)) and alpha-lipoic acid treatment was continued for three more days. The increased level of serum enzymes (aspartate transaminase, alanine transaminase and alkaline phosphatase), bilirubin, lipids and plasma thiobarbituric acid-reactive substances (TBARS) and hydroperoxides observed in rats treated with chloroquine were very much reduced in rats treated with alpha-lipoic acid plus chloroquine. A significant decrease in plasma antioxidants such as reduced glutathione (GSH), vitamin C and vitamin E were observed in chloroquine-treated rats when compared with control rats. Administration of alpha-lipoic acid significantly improved the levels of plasma antioxidants GSH, vitamin C and vitamin E in chloroquine-treated rats. In the case of 100 mg x kg(-1) day(-1) the effect was highly significant compared with the other doses (10 and 30 mg x kg(-1) day(-1)).
The results of the study revealed that alpha-lipoic acid could offer protection against chloroquine-induced hepatotoxicity. alpha-Lipoic acid had a better protective effect when compared with silymarin, a reference drug. Copyright 2004 John Wiley & Sons, Ltd.
Bueno este es solo un estudio al asar, sobre ratas donde se indujo una intoxicación hepática y fue tratada con acido tioctico... pero hay muchos mas... el alpha-lipoic acid es el acido tioctico para los ke no lo saben , y si , es mucho mas efectivo ke la silimarin (Milk Thistle) . El hígado esta en constante trabajo siempre... y si lo exigimos mas con el uso de esteroides , al metabolizarlos el trabajo ke debe de hacer es todavía mayor , dependiendo del tipo de esteroide ke estemos usando... esto lo aliviana un poco... yo trato de usarlo solo los días ke no me alimento de una manera "sana" por decirlo asi... frituras... grasas.. y tal ves alguna copita jejej... no siempre.... y ganancias les aseguro ke no me resto.. vaa , no se , capas tendria ke estar mas grande
jejejej... es broma , al menos mi ultimo hepatograma me dio perfecto... veremos dentro de 1 mes ke me haga el próximo y les cuento.
Saludos muchachos...