SELEGILINE for Prolactin

[MTS]

I'm taking Tren and started to get some prolactin sides really fast...i took SELEGILINE CITRATE and the sides when away by the next day. SELEGILINE CITRATE is really great for prolactin and i would recommend anyone wanting to save money on a tren cycle try SELEGILINE instead of CABERGOLINE.

 

[macrophage69alpha]

highly reccomend selegiline, not just for prolactin issues but also for its nootropic and neuronal health benefits

 

[SlimJim300]

This is deprenyl, correct?

 

[doublefister]

highly reccomend selegiline, not just for prolactin issues but also for its nootropic and neuronal health benefits

What is the recommended dosage for preventing prolactin issues? Are there any articles on selegine for this because all I see is that its for cushings disease, parkinson's disease, depression. Everything but for prolactin issues.

 

[macrophage69alpha]

What is the recommended dosage for preventing prolactin issues? Are there any articles on selegine for this because all I see is that its for cushings disease, parkinson's disease, depression. Everything but for prolactin issues.

Clin Neuropharmacol. 2003 Jul-Aug;26(4):193-5. Links
Selegiline in the treatment of sexual dysfunction in schizophrenic patients maintained on neuroleptics: a pilot study.Kodesh A, Weizman A, Aizenberg D, Hermesh H, Gelkopf M, Zemishlany Z.
Lev Hasharon Mental Health Medical Center, Pardessiya, Israel.

A double-blind, placebo-controlled crossover study was undertaken in 10 neuroleptic-treated male schizophrenic outpatients to assess the effect of coadministration of selegiline 15 mg/day for 3 weeks on their sexual dysfunction. Selegiline was not found to be effective in improving any domain of sexual functioning despite a significant decrease in prolactin levels (P < 0.05). This study emphasizes the complex nature of sexual dysfunction in schizophrenic-treated patients and the need for placebo-controlled trials for this condition.

 

[macrophage69alpha]

Pharmacopsychiatria. 1983 Sep;16(5):143-6. Links
An early phase II trial with L-deprenyl for the treatment of neuroleptic-induced parkinsonism.Perenyi A, Bagdy G, Arato M.
The effect of L-deprenyl on neuroleptic-induced parkinsonism was evaluated in eleven patients. No significant improvement was observed during the treatment with L-deprenyl in the overall assessment. Four patients, however, were considered responders as their total scores on the modified version of Neurological Rating Scale decreased by at least 50%. No somatic or mental complications were observed during the study. The pretreatment platelet monoamine oxidase activity of the responders was slightly but not significantly higher than that of the non-responders. The plasma prolactin (PRL) levels of the patients with high pretreatment levels decreased significantly during the administration of L-deprenyl.

 

[trader]

Something AG guys needs to look into offering.

 

[MTS]

What is the recommended dosage for preventing prolactin issues? Are there any articles on selegine for this because all I see is that its for cushings disease, parkinson's disease, depression. Everything but for prolactin issues.

i used 2.5 the first day and followed up with 1.25 three days later, and maintained 1.25 every three days.
I am only 25 so the dosage might be higher in older males

 

[vitamix]

Something AG guys needs to look into offering.

Agreed. They should be dabbling in other nootropics as well.

 

[macrophage69alpha]

get it from IAS smart-drugs.

quite dissapointed with the "research" places

 

[Smokescreen]

highly reccomend selegiline, not just for prolactin issues but also for its nootropic and neuronal health benefits

Macro, would it be total overkill to use both Selegine and Dostinex at the same time?

 

[MR. BMJ]

Macro, What would you recommend as a dose for Selegiline to combat prolactin (low end-high end dosing)?

Also,

How effective is Tyramine in combatting prolactin? and an effective dose?

Thanks buddy!

BMJ

 

[MR. BMJ]

Bump for Macro....

BMJ

 

[macrophage69alpha]

Macro, What would you recommend as a dose for Selegiline to combat prolactin (low end-high end dosing)?

Also,

How effective is Tyramine in combatting prolactin? and an effective dose?

Thanks buddy!

BMJ

5-20mg

varies, can be quite effective. 100mg-200mg 2-3 times a day.

if you use both use only low dose selegiline high dose can inhibit mao-a causing you to get too much tyramine

do not take tyramine with mao-a inhbitors

 

[MR. BMJ]

Cool! Thanks Macro!

Maybe i'll try out AlTyr from AF in the future for this purpose. At 5-20mg/d of deprenyl, that can get expensive.....although I do like the cognitive benefits that it adds.

Do you think the addition of B6 with altyr will be of any synergistic benefit?

BMJ

 

[Triple J]

you may find a lower dose effective, macro's is a pretty high dose of selegiline, although that may be what studies show. i'm just saying the dose is highly individual. the advantage of the liquid selegiline citrate products is you can easily titrate the dose to meet your needs.

carth asked about taking selegiline with dostinex and i would strongly advise against this practice

for naturally combatting prolactin you may want to consider B6, I think around 200-300mg/d (time released or divided 2/3x day) and tyrosine

 

[macrophage69alpha]

you can use a lower dose with the selegiline citrate, though you also need to take it sublingually and the solution tends to make the mouth water often causing "washing away" reducing the benefit over the HCL tablets. still ratio wise better than the hcl tablets for uptake, but not as good as it could be.

20mg is the high end dosing, generally 5-10mg is sufficient

b6 can be effective (ultra high dose 600mg per day), though many report no effect. Because the lowering effect is considerably less than found with dopaminergic drugs (studies indicate 30-50% vs.80-95%)

 

[macrophage69alpha]

^^

 

[posthuman]

Could someone post data that shows that tren or any other AAS increases prolactin levels?

Thanks.

 

[MR. BMJ]

You will not find any human studies/data.

Here is from a post that cockdezl posted a few years back:

"APMIS 2000 Dec;108(12):838-46"

"Characterisation of the affinity of different anabolics and synthetic hormones to the human androgen receptor, human sex hormone binding globulin and to the bovine progestin receptor."

Bauer ER, Daxenberger A, Petri T, Sauerwein H, Meyer HH.

Institut fur Physiologie, Research Center for Milk and Food Weihenstephan, Technical University Munich, Germany.

"For the steroidal growth promoters trenbolone acetate (TBA) and melengestrol acetate (MGA) neither the complete spectrum of biological activities nor the potential endocrine disrupting activity of their excreted metabolites in the environment is fully understood. The potency of these substances in [3H]dihydrotestosterone ([3H]-DHT) displacement from the recombinant human androgen receptor (rhAR) and from human sex-hormone binding globulin (hSHBG) was evaluated. In addition, the potency for [3H]-ORG2058 displacement from the bovine uterine progestin receptor (bPR) was tested. For comparison, different anabolics and synthetic hormones were also tested for their binding affinities. For 17beta-trenbolone (17beta-TbOH), the active compound after TBA administration, an affinity the rhAR similar to dihydrotestosterone (DHT) and a slightly higher affinity to the bPR than progesterone were demonstrated. The affinity of the two major metabolites, 17alpha-trenbolone and trendione, was reduced to less than 5% of the 17beta-TbOH-value. The affinity of these three compounds and of MGA to the hSHBG was much lower compared with DHT. MGA showed a 5.3-fold higher affinity than progesterone to the bPR but only a weak affinity to the rhAR. The major MGA metabolites have an affinity to the bPR between 85% and 28% of the affinity of progesterone. In consequence, MGA and TBA metabolites may be hormonally active substances, which will be present in edible tissues and in manure. We conclude that detailed investigations on biodegradation, distribution and bio-efficacy of these substances are necessary."

"NOTE: this study showed that tren had a HIGHER affinity to the PR than did PROGESTERONE."

BMJ

 

[MR. BMJ]

Didn't really state that it raised prolactin levels, but felt like posting it anyway. I'm too lazy to look for anything right now.

BMJ

 

[posthuman]

Didn't really state that it raised prolactin levels, but felt like posting it anyway. I'm too lazy to look for anything right now.

BMJ

Yeah exactly, haven't seen ANY data showing these steroids raise prolactin. I have however seen data showing nandrolone for example does NOT raise prolactin.