yes, there are a few things you need to consider.
1. You have good running shoes, and i don't mean going to niketown etc and picking up what they consider to be good running shoes. Go to a proper running store and get on a treadmill with the trainers you are considering buying. Running shoes also expire within six to nine months.
2. Get a really good sports bra. Get a really good sports bra. I can't emphasis this enough. Actually, you are better getting two. There is no point in getting fit if you are going to do tremendous damage to your breasts, as running will do this. And no, it doesn't matter if your breasts are small.
3. If you have any issues with your knees/ankles/hips, it may not be the best for you. It is also advisable to rotate to different cardio training as running is quite hard on your joints.
4. Running for more than 45-60 minutes at any one time is going to suppress your immune system, so unless you are training for a marathon, keep your sessions to less time than this.