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needtogetaas
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receptor cross over
OK so let brake things down into simple terms first before I go into detail about "receptor cross over"
First thing is first lets talk about hormones and hormone receptors and how they work. The most simple way I have seen it explained is this. Hormones are keys and your receptors are like locks. I have also seen it explained hormones are cars and the receptors are parking lots.
But for this one we will use Keys and locks. Keep this in mine through out this thread/post. Keys and locks.
What happens is a hormone is ether placed in the body (by an out side source) or it is produced with in the body. This hormone we will call a "key". The hormone then sets out to find a "lock" that it can fit into,turn, and sequentially open up the
components inside.
Imagine your receptors are little treasure chest. Inside the chest is a set of instructions. This set of instructions can be a number of things. It can be directions to another chest or a task that must now be carried out. With out something to open the chest the instructions can never be carried out or the next chest found and opened. Following me ?
Lets go deeper. Some hormones are more like AAAAAH hmmm "dummy keys" will call them. They will find a "lock" and set them self into the "Lock hole" but then that is it. They never turn the key and open up whats inside. HMMMM interesting I think. So we have the following
1. Key fits a lock. AKA a hormone found a lock and set its self into it. Pretty simple
2. Key was not a dummy key and when it set its self into the lock it turned and opened up the chest letting out the instructions inside that will now be carried out.
This is the simple part that almost everyone on every forum understands. Estrogens keys fit into the ER( estrogen receptor) key hole. Progesterones fit into the PR ( progesterone receptor) key hole. Androgens fit into the AR (androgen receptor) key holes. So on and so forth, its pretty simple and almost everyone knows and understands this.
However its not as simple as everyone has accustom to believing. Receptor cross over dose happen and more then one would think. How would one explain receptor cross over? Well again I will first make it simple.
"master keys" We will call them. Or "Muti function keys"
A subject not much talked about on any of the steroid forums or even in many articles I have come across is the fact that. In respect to anabolic steroids (out side source of hormones) most of them have all been explained as just "lock" and "key" . However the truth is pro hormones,designer steroids and steroids all have "Multi function" and some even "Master key" functions.
Even with as simple as I have explained things I am sure by now you are asking yourself "what this guy talking about?" Of course you are, keep reading!!!!
Ok to start off lets take A few threads like these
http://www.elitefitness.com/forum/gynecomastia/halotestin-gyno-667063.html
http://www.elitefitness.com/forum/gynecomastia/so-how-does-anadrol-cause-gyno-514327.html
http://www.elitefitness.com/forum/gynecomastia/anadrol-gyno-454985.html
And even every once in a wile
http://www.elitefitness.com/forum/gynecomastia/winny-gyno-535505.html
http://www.elitefitness.com/forum/gynecomastia/uhhhh-winny-gyno-269237.html
http://www.elitefitness.com/forum/anabolic-steroids/so-i-found-out-709815.html
SO as we can see there is a lot of people shooting in the dark at a target they can not see. When some one can not explain something there reaction is OOOO you must not have real winny or ya abomb cause estrogen sides, or even things like " your anavar must be fake"
Only when you look more into things you will find that both anadrol and winny Are dht derivatives, nether can convert to estrogen or prgesterone. Nether can anavar.
So then what?
AAAHHH In walks receptor cross over aka "Multi function" "master keys"
"Mutli function" Or "master key"<-- Simple terms
Or as I like to call it
"receptor cross over"
What happens is The body recognizes the androgen/hormone but to the body it may also look a bit like another hormone. When the drug flows through the body enough times (through taking it over and over through out a cycle). Some times the body will except it into a receptor it was not meant for.
Receptor crossover Is what happens when a steroid hormone acts at a receptor other then what it was meant for. It binds to or interacts with a receptor other then what everyone normally knows or expects it to do so. This intercommunication between hormones and there non native receptors results in ether activation/blocking or semi agonism ( a stimulation of the receptor that results in less activation then the receptors parent hormone.
This is why we often see threads made by people talking about how they got gyno during a winny only, var only, beastdrol only cycle. Leaving many people saying " o then you must have gotten fake var" or Your winny must have been mixed with dbol"
The fact is all hormones to a lesser degree ( and some more then others) cross activate other receptors directly or indirectly. And the answer is not always " you got sold the wrong steroid.
It should also be taken into account that every persons dna/genetic make is different. This is why many steroids act completely different in there results and side effects from one user to the next.
Although there is not a lot of studies done on this subject the topic is getting disused more and more by scientist and industry leaders. I have no doubt that its a topic we will be hearing much more of in the years to come.
I know I will be watching this subject closely and I am happy to say I am one of the first to attempt to bring it into the mainstream.
In the event of receptor cross over causing gyno there is a questions that is left unanswered. Its a question that I have seen many people stuck with. Going over the threads I linked to above, and many others like it. you can see there is a pattern. A pattern that has gone one for a long time.
Reading over these threads you may dismiss it as some one getting aomething other then the drug they think they got. But what about that person? For them they are not so dismissive. Often they know for a fact they got the drug they paid for and even in some cases have tested the drug and seen with there own eyes that it is in fact the drug they paid for.
Because its isolated and the people it effects are few and far between it has been easy for the rest of the steroid world to ignore ans dismiss the facts.
For the people that have this problem how do they take care of it? I think the only way is to block the receptor?
Now when it comes to blocking the ER this is easy we have compounds like nolva and clomid for this. What about blocking the PR though? We do have compounds that reduce progesterone and also compounds that reduce or block prolatin but thus far nothing common that blocks the pr with out causing activation....
Though I have seen some studies showing things like methoxy or the day after birth control pill being able to block the PR, not much is known or written about this. Maybe we will see more in the future
OK so let brake things down into simple terms first before I go into detail about "receptor cross over"
First thing is first lets talk about hormones and hormone receptors and how they work. The most simple way I have seen it explained is this. Hormones are keys and your receptors are like locks. I have also seen it explained hormones are cars and the receptors are parking lots.
But for this one we will use Keys and locks. Keep this in mine through out this thread/post. Keys and locks.
What happens is a hormone is ether placed in the body (by an out side source) or it is produced with in the body. This hormone we will call a "key". The hormone then sets out to find a "lock" that it can fit into,turn, and sequentially open up the
components inside.
Imagine your receptors are little treasure chest. Inside the chest is a set of instructions. This set of instructions can be a number of things. It can be directions to another chest or a task that must now be carried out. With out something to open the chest the instructions can never be carried out or the next chest found and opened. Following me ?
Lets go deeper. Some hormones are more like AAAAAH hmmm "dummy keys" will call them. They will find a "lock" and set them self into the "Lock hole" but then that is it. They never turn the key and open up whats inside. HMMMM interesting I think. So we have the following
1. Key fits a lock. AKA a hormone found a lock and set its self into it. Pretty simple
2. Key was not a dummy key and when it set its self into the lock it turned and opened up the chest letting out the instructions inside that will now be carried out.
This is the simple part that almost everyone on every forum understands. Estrogens keys fit into the ER( estrogen receptor) key hole. Progesterones fit into the PR ( progesterone receptor) key hole. Androgens fit into the AR (androgen receptor) key holes. So on and so forth, its pretty simple and almost everyone knows and understands this.
However its not as simple as everyone has accustom to believing. Receptor cross over dose happen and more then one would think. How would one explain receptor cross over? Well again I will first make it simple.
"master keys" We will call them. Or "Muti function keys"
A subject not much talked about on any of the steroid forums or even in many articles I have come across is the fact that. In respect to anabolic steroids (out side source of hormones) most of them have all been explained as just "lock" and "key" . However the truth is pro hormones,designer steroids and steroids all have "Multi function" and some even "Master key" functions.
Even with as simple as I have explained things I am sure by now you are asking yourself "what this guy talking about?" Of course you are, keep reading!!!!
Ok to start off lets take A few threads like these
http://www.elitefitness.com/forum/gynecomastia/halotestin-gyno-667063.html
http://www.elitefitness.com/forum/gynecomastia/so-how-does-anadrol-cause-gyno-514327.html
http://www.elitefitness.com/forum/gynecomastia/anadrol-gyno-454985.html
And even every once in a wile
http://www.elitefitness.com/forum/gynecomastia/winny-gyno-535505.html
http://www.elitefitness.com/forum/gynecomastia/uhhhh-winny-gyno-269237.html
http://www.elitefitness.com/forum/anabolic-steroids/so-i-found-out-709815.html
SO as we can see there is a lot of people shooting in the dark at a target they can not see. When some one can not explain something there reaction is OOOO you must not have real winny or ya abomb cause estrogen sides, or even things like " your anavar must be fake"
Only when you look more into things you will find that both anadrol and winny Are dht derivatives, nether can convert to estrogen or prgesterone. Nether can anavar.
So then what?
AAAHHH In walks receptor cross over aka "Multi function" "master keys"
"Mutli function" Or "master key"<-- Simple terms
Or as I like to call it
"receptor cross over"
What happens is The body recognizes the androgen/hormone but to the body it may also look a bit like another hormone. When the drug flows through the body enough times (through taking it over and over through out a cycle). Some times the body will except it into a receptor it was not meant for.
Receptor crossover Is what happens when a steroid hormone acts at a receptor other then what it was meant for. It binds to or interacts with a receptor other then what everyone normally knows or expects it to do so. This intercommunication between hormones and there non native receptors results in ether activation/blocking or semi agonism ( a stimulation of the receptor that results in less activation then the receptors parent hormone.
This is why we often see threads made by people talking about how they got gyno during a winny only, var only, beastdrol only cycle. Leaving many people saying " o then you must have gotten fake var" or Your winny must have been mixed with dbol"
The fact is all hormones to a lesser degree ( and some more then others) cross activate other receptors directly or indirectly. And the answer is not always " you got sold the wrong steroid.
It should also be taken into account that every persons dna/genetic make is different. This is why many steroids act completely different in there results and side effects from one user to the next.
Although there is not a lot of studies done on this subject the topic is getting disused more and more by scientist and industry leaders. I have no doubt that its a topic we will be hearing much more of in the years to come.
I know I will be watching this subject closely and I am happy to say I am one of the first to attempt to bring it into the mainstream.
In the event of receptor cross over causing gyno there is a questions that is left unanswered. Its a question that I have seen many people stuck with. Going over the threads I linked to above, and many others like it. you can see there is a pattern. A pattern that has gone one for a long time.
Reading over these threads you may dismiss it as some one getting aomething other then the drug they think they got. But what about that person? For them they are not so dismissive. Often they know for a fact they got the drug they paid for and even in some cases have tested the drug and seen with there own eyes that it is in fact the drug they paid for.
Because its isolated and the people it effects are few and far between it has been easy for the rest of the steroid world to ignore ans dismiss the facts.
For the people that have this problem how do they take care of it? I think the only way is to block the receptor?
Now when it comes to blocking the ER this is easy we have compounds like nolva and clomid for this. What about blocking the PR though? We do have compounds that reduce progesterone and also compounds that reduce or block prolatin but thus far nothing common that blocks the pr with out causing activation....
Though I have seen some studies showing things like methoxy or the day after birth control pill being able to block the PR, not much is known or written about this. Maybe we will see more in the future
