since its basically DHT, if you're predisposed to MPB, it will of course accelerate that process.
additionally, whether u are or arent predisposed to MPB, high enuf doses (depends on ur tolerence) will cause a Telogen Effluvium which sucks alot. If ur mpb predisposed it may not grow back, if ur not mpb-predisposed you'll get most if not all of it back (but look like a dog with mange for a few months lol).
I found I can minimize the effect of androgens on my scalp with high doses of B-5 (1500 mg 3 or 4 times a day). Probably has to do with mitigating the oil-related stranagulation of the follicle.