one thing i;ve always wondered about ALA...

[danielson]

with say glucocorticoid (i think) steroids, if you take them for too long you can get atrophy of the adrenal glands due to long term negative feedback (i.e. because you are artifically introducing corticosteroids into the blood stream the adrenals produce less of their own and as a result shrink long term)

now i understand that the action of ALA is not that of insulin, it doesn;t act like a hormone but rather increases the insulin sensitivty of cells. but by doing so im curious as to whether the body realises that blood sugar levels are dropping faster than expected for the levels of insulin being secreted and thus reduces its pancreatic secreton of insulin

now im unaware of whether the pancreas will reduce its B-cells or if it even can but i am wondering whether it will reduce its insluin secreteons when taking ALA and whether it will bring them back up once it has finshed being taken.

i;ve not seen it anywhere in the readng i've done on the supplement which has been 100% postive (of R-ALA anyway), but i;d like to know if it is a concern.

it sounds like a great supp, and i really wanna shred up (having never got past 11%bf before) and this seems like the best way...any thoughts? be as technical as you need to....i have a science/bio background

 

[ZKaudio]

doesn't biotin have a role in preventing ^

 

[danielson]

by what mechanism? im unsure how it can as i;ve never seen biotin mentoned as an essential co-enzyme for insulins actions

 

[danielson]

bump for an answer....if it can help me looked toned i'd love to try it

 

[dr0832]

I thought your suppose to take ala when bulking?

 

[Clean]

you can take it when bulking or cutting

 

[danielson]

yup, i wanna take it when cutting

but the only thing stopping me and others i know from taking it is the long term effects it could have, since i have a genetic pre-disposition to developing diabetes.....

i;ve seen all the data about what it can do, but nothing about the long term effects on cells having the glut-4 receptor upregulated

 

[MuscleKSU]

I don't believe this would occur. Beta cells in the pancreas can be destroyed by autoimmune function (as in type 1 diabetes). However, that is a genetic defect. That is the only thing I know of that would cause beta cell destruction.

Ryan

 

[danielson]

bump again....i really wanna take it as do many friends but we're all concerned about any potential for reduction of insulin secreteion or action

 

[Lao Tzu]

what did you ever find out on the subject? I'm in the same boat you are diabetes runs in my family and i want to use ALA long term for weight loss maintenance.

there are diabetes drugs that already exist that increase insulin sensitivity called thiazolidinediones. I'm sure research has been done on them to detect for a negative feedback loop. My pharmacology book doesnt make any mention of negative feedback but studies may have been done on the subject.