busdriver1 said:
I love fina, dont get me wrong, It has giving me gyno 2 times ...
I am taking *test-fina-winny*, I am also on *nolva, femara, and bromo*. I still got freakin gyno!
Pet peeve...Postings that say "<fill in blank> is doing <blank>". But then we find out that actually several <fill in the blanks> are involved.
Let's try killing this myth again...
There is NO SUCH THING as "progesterone-induced Gyno".
I know, I know...stupid statement, after all we've all seen progesterone gyno posted thousands of times on the boards. (Including from me.) We'll it's not so stupid...
Several hormones are involved in breast development but only *estrogen* is involved in duct growth. No estrogen, no gyno.
What many people don't realize is that Trenbolone (Fina) DOWN-regulates Estrogen Receptors. Taking bromo, according to the theory, lowers progestin levels which would counter Trenbolone's down-regulation of estrogen receptors. It's effect on the PR probably upregulates the Estrogen Receptor. Winny is also used as a progesterone blocker by some fina users, but the medical research shows that while it binds to the PR it does not block progesterone production. Progesterone blockers are a PROVEN inducer of gynocomastia. To finish the trifecta, add in a bunch of testosterone and watch the excess aromatise into estrogen.
In this cycle Nolvadex and Femara would reduce the aromatase, however larger doses than what were taken were probably necessary. Especially with the combination of Bromo and Winny making the ER more sensitive.
For those who are ready to shoot me down, show me medical evidence (and gyno has seen lots of research) that ductal tissue grows without the presence of estrogen.
Here is some documentation (most found by Nandi12):
http://www.endotext.org/male/male14/male14.htm
http://www.bromocriptine.com/
http://www.femara.com/home/index.jsp
Int J Biol Markers 1995 Jan-Mar;10(1):47-54
Progesterone agonists and antagonists induce down- and up-regulation of estrogen receptors and estrogen inducible genes in human breast cancer cell lines.
Int J Biochem Cell Biol 1997 Feb;29(2):361-6
Antiandrogenic effect of RU-486 in the mouse kidney.
Tovar A, Sanchez-Capelo A, Galindo JD, Cremades A, Penafiel R.
Department of Biochemistry, Faculty of Medicine University of Murcia, Spain.
Case report: finasteride-induced gynecomastia in a 62-year-old man.
Am J Med Sci 1995 Jun;309(6):322-5
Volpi R, Maccarini PA, Boni S, Chiodera P, Coiro V.
Thompson DF, Carter J: Drug-induced gynecomastia. Pharmacotherapy 13(1): 37-45, 1993
Tamoxifen for flutamide/finasteride-induced gynecomastia.
Staiman VR, Lowe FC.
Fortschr Med 1998 Dec 20;116(35-36):18-22
Gynecomastia in men
Bullmann C, Jockenhovel F.