Hello guys! This is my first post!
There are actually some compounds that have shown a slow to fast muscle fiber transformation..
Some of them are:
clenbuterol-albuterol(and all the b-2 adrenergic agonists and maybe everything that mimics adrenaline),
T3
cyclosporine a - FK506 (via inhibition of calcineurin)
vitamin D3
coenzyme q10
I also think that forskolin can do that, via activation of cAMP..
Maybe, this is how clenbuterol also acts to muscle fiber phenotype..So, maybe phosphodiesterase-4 inhibitors like rolipram,hesperidin,luteolin, etc could work...
Some supplements that inhibit calcineurin are
caffeic acid, catnip, punicalagin(from pomegranate), kaempferol, quercetin, salvia miltiorrhiza...
Calcineurin inhibitors, also protect from clenbuterol-induced cardiac hypertrophy..
Sure there are many others,also acting through another pathways..
Lastly, electrical muscle stimulation of high frequency (120hz)
converts some slow twich fibers to fast ones...