fogg88 said:As far as actual bioavailability goes, the chemical structure of a synthetic vitamin is no different that that of a 'natural' vitamin. Your body doesn't know the difference. As long as there are macronutrients (protein, carbs, fat) in the digestive system for the vitamins to bind to, they will cross into the bloodstream just as well as food-based vitamins.
I was talking about bioavailability in the sense of absorption. Not necessarily the body's absorption rate chemically.
If the tab does not allow for ease of transport across the GI barrier, then it lowers the bioavailability.