Ibuprofen and Training

[Temple]

I didn't get to see all of it but from what I gathered CU is conducting a study on the effect of ibuprofen use and training. It seems they think that taking ibuprofen prior to training may negate some of the benefits of exercise primarily on bone strength. I also read in a seperate article while researching my back problem that use of ibuprofen and tylenol will interfere with healing when injured.
MS or W6 -do either of you know anything about this?

 

[bignate73]

from what ive heard, ibuprofin is hard on the liver as well. but then again....what isnt?

 

[JJFigure]

I read something about ibuprofen interfering with the muscle tear/re-build process of weightlifting, so I tend to completely avoid it. I'm sure it probably only interferes if you're taking a lot, but better safe than sorry.

 

[JJFigure]

I must have been hallucinating. I've been trying some web searches to see if I can find more info on whether or not ibuprofen has a negative influence on weight training, and I'm coming up with nada.

 

[wilson6]

This is what you're looking for.

Am J Physiol

Vol. 282, Issue 3, E551-E556, March 2002

Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis

T. A. Trappe1, F. White1, C. P. Lambert1, D. Cesar2, M. Hellerstein2, and W. J. Evans1

We examined the effect of two commonly consumed over-the-counter analgesics, ibuprofen and acetaminophen, on muscle protein synthesis and soreness after high-intensity eccentric resistance exercise. Twenty-four males (25 ± 3 yr, 180 ± 6 cm, 81 ± 6 kg, and 17 ± 8% body fat) were assigned to one of three groups that received either the maximal over-the-counter dose of ibuprofen (IBU; 1,200 mg/day), acetaminophen (ACET; 4,000 mg/day), or a placebo (PLA) after 10-14 sets of 10 eccentric repetitions at 120% of concentric one-repetition maximum with the knee extensors. Postexercise (24 h) skeletal muscle fractional synthesis rate (FSR) was increased 76 ± 19% (P < 0.05) in PLA (0.058 ± 0.012%/h) and was unchanged (P > 0.05) in IBU (35 ± 21%; 0.021 ± 0.014%/h) and ACET (22 ± 23%; 0.010 ± 0.019%/h). Neither drug had any influence on whole body protein breakdown, as measured by rate of phenylalanine appearance, on serum creatine kinase, or on rating of perceived muscle soreness compared with PLA. These results suggest that over-the-counter doses of both ibuprofen and acetaminophen suppress the protein synthesis response in skeletal muscle after eccentric resistance exercise. Thus these two analgesics may work through a common mechanism to influence protein metabolism in skeletal muscle.

W6