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Do carrier oils really matter? (The things that make you go hmmm)
Yes it does matter for "some".. Carrier oils release at different rates, thus this will effect the serum levels of the parenting hormone, however the carrier really has little effect on a scale that you or anyone would even notice aside from its " kinetic profile under clinical investigation/studies" , although administration with certain carriers may yield different toxicological profiles for the same drug, some reaching supraphysiological serum testosterone levels, but this will vary with administered route (whether IM or subQ), different esters, individuals and so on..Also, different regions favor one oil over the other like western pharmacopoeia practice may often and commonly use Grape-seed, as in other regions of the world with therapies some use tea-seed oil,soy and cottonseed with the same promising returns (pro's and con's with both oils), much like Enanthate is manufactured in Europe for TRT, while Cypionate is manufactured in the U.S. Testosterone Cypionate and Enanthate both steroids have the same effects and functions, whilst there are studies claiming the longevity effect of Cypionate compared to Enanthate differ,but we know it's irrelevant on the small scale..The same can be seen and recognized with carriers to a degree, this is why most UGL's will use the same carriers to keep release time with-in a narrow range of others..
Now if we're talking about supraphysiological serum testosterone levels, with shorter esters in different carrier oils that possess different half-life/molecule weight (yes carrier half life's), with different routes of administration? Sure, we can see levels exceeding upper limits, but the extended release will balance out with a decline (ester dependent), this is just a quesstimation as there will be many variables to conciser (age,genetics) but you get the jist on the generalization here.
In the grand scheme of it all, It comes down to 90% allergies and oil-Viscosity..Site reaction,and immune response, and even hormone release (castor oil has a slow,stable,steady release for heavier esters due to its longer half-life)..However for most generally used carriers the viscosity really isn't that different when compared through kinematic viscosity measurement (mm2/s) - Fluid resistance..
When being measured they're off by a few digits, but that's so insignificant..It's mainly immune response/allergies/site irritation..
Below is a template of kinematic viscosity measurements (mm2/s) - Fluid resistance with most major carrier oils. Top being thickest, and last being thinnest..I hope this helps..
Castor 297.0
Crambe 53.6
High-Oleic Safflower 41.2
Peanut 39.6
Sunflower 37.1
Grapeseed 37.0
Sesame 35.3
Corn 34.9
Cottonseed 33.5
Soybean 32.6
Safflower 31.3
MCT 25-33
Here is a study explaining how "castor oil" has a longer half-life than most traditionally used carriers in general practice
Intramuscular injection of testosterone undecanoate for the treatment of male hypogonadism: phase I studies.
Behre HM1, Abshagen K, Oettel M, Hübler D, Nieschlag E.
Author information
Abstract
OBJECTIVE:
In the search for long-acting testosterone preparations suited for substitution therapy of hypogonadal men, testosterone undecanoate (TU) dissolved in either tea seed oil or castor oil was investigated.
DESIGN:
In study I, 1000 mg TU in tea seed oil (125 mg/ml) were injected in equal parts into the gluteal muscles of seven hypogonadal men. In study II, 1000 mg TU in castor oil (250 mg/ml) were injected into one gluteal muscle of 14 patients.
RESULTS:
In comparison with published data on testosterone enanthate, most widely used for i.m. injections, the kinetic profiles of both TU preparations showed extended half-lives and serum levels not exceeding the upper limit of normal. The castor oil preparation had a longer half-life than TU in tea seed oil (33.9+/-4.9 vs 20.9+/-6.0 days (mean pm S.E.M.)).
CONCLUSION:
The longer half-life and the smaller injection volume make TU in castor oil a strong candidate for further applications in substitution therapy and in trials for male contraception.
Abstract
In the search for long-acting testosterone preparations suited for substitution therapy of hypogonadal men, testosterone undecanoate (TU) dissolved in either tea seed oil or castor oil was investigated.In study I, 1000 mg TU in tea seed oil (125 mg/ml) were injected in equal parts into the gluteal muscles of seven hypogonadal men. In study II, 1000 mg TU in castor oil (250 mg/ml) were injected into one gluteal muscle of 14 patients.In comparison with published data on testosterone enanthate, most widely used for i.m. injections, the kinetic profiles of both TU preparations showed extended half-lives and serum levels not exceeding the upper limit of normal. The castor oil preparation had a longer half-life than TU in tea seed oil (33.9+/-4.9 vs 20.9+/-6.0 days (mean pm S.E.M.)).The longer half-life and the smaller injection volume make TU in castor oil a strong candidate for further applications in substitution therapy and in trials for male contraception.
Below is a great read about treatments, and serum levels with carrier oils!
Intramuscular injection of testosterone undecanoate for the treatment of male hypogonadism: Phase I studies
Last but not least let's talk about MCT oil?
One of the most user friendly carrier vehicle oils used in medical practices world wide. -
All Euro-Pharmacies oils are all synthetic and made with the finest pharma grade vehicle oils on the market,
some of these same carries are used world wide in clinics all around the world to avoid lymphatic acute reactions,
absolute NO food derivatives in order to avoid site irritation or localize swelling for utmost comfort!
Sensitive info
With Euro-Pharmacies Oil based compounds - Absolutely NO EO-OIL is used or other food derivatives for carrier delivery method of all parenting hormones due to allergic reactions with some carries.
EP's oil base products are smooth with less site irritation like most other carriers, while providing a more stable and longer shelf life of the suspended drugs.
EURO-PHARMACIES MANUFACTURING METHODS , SUPPLIES , SEMI PRODUCTS AND ALL OPERATING ELEMENTS ARE COMPLETELY/CONSTANTLY UP TO DATE WITH ALL THE LATEST GLOBAL STANDARDS.
1. Carrier Oils used in EP Injectable Products Line manufacturing processes are completely Pharmaceutical Grade.
100% Synthetic , Hypoallergenic and Completely Clear/Transparent in terms of Color properties.
(No tint- No impurity and Completely Infection/Contamination Proof)
A. Hormone Raw Materials batches applied in production processes Can Naturally differ in Color Tint Properties
Therefore it's sometimes possible that some particular EP Line Product Batches can differ in terms of color tint rate.(Due to 100% Clear - Transparent Carrier Oil Appearance Property)
2. Solely Pharmaceutical Grade Hormone Raw Materials used in EP Injectable Products Line manufacturing processes.
(Provided only by Official and Certified Pharmaceutical Manufacturers)
3. Solely Pharmaceutical Grade Hormone Raw Materials used in EP Oral Products Line manufacturing processes.
A. Professional and HIGHEST QUALITY Fillers applied to EP Oral Products Line. (ie. starch , PVP etc.)
More info
EP Line Crystal Clear|Pro. Carrier Oils Clarification
Original EP Line always used only Professional/Legit Pharma Grade Carrier Oils "Inside".
EP Line PG carrier Oils were SOLELY Created and Produced for "PG" AAS.
Of course products like Deca and all Trens are an exception clearly - due to their "essence" used ...
EP Line uses only Pharma Grade carrier oils (synthetic/hypoallergenic/smooth/most efficiently dissolved-merged with the "essence" - professional oil used only in Original Pharm. Grade Products)
No UGL on the market uses such Pro./Expensive Oils to our knowledge.Those carrier oils are available only to Legit/Registered Pharma Grade Manufacturers ... and to Us.
(We sincerely apologize if we EVENTUALLY missed anything on any UGL on the market about that matter)
EP Line carrier oils proved with 100% certainty:1. Second to None - Highly smooth and Painless injection experience.
2. Body/System 100% Smooth & Effective applicability and response.
3. 100% Pharma Grade Feature of: dissolving/applying with the "essence" in the system/body right from the start.
EP Line "Essence" Origin and Quality matches those PG Carrier Oils Fully naturally.
What is Miglyol 812?
Miglyol 812 is also a clear neutral oil. Miglyol 812 is a liquid form of an MCT oil. An MCT oil is a medium-chain triglyceride. A medium-chain triglyceride is a man-made fat that that is partially manmade. It is identified by the way the carbon atoms are rearranged in the structure. Many people use MCTs, which are typically derived from coconut and palms oils and dairy fats, for improved diet and weight management.
According to the Cleveland Clinic, MCTs decrease metabolic syndrome, reduce abdominal obesity, and boost weight loss. Like miglyol 840, miglyol 812 is desired in toxicology and pharmaceuticals because it improves the solubility and absorption of injectables and oral compounds. Miglyol is soluble at 20 degrees Celsius. Additional properties of miglyol 812 are spreadability, penetration-promoting application, and high stability compared to natural oils. When used as a lotion, cream, or any other spreadable application, miglyol 812 is permeable and non-greasy; therefore, it does not obstruct the skin’s natural respiration.
Whether we use miglyol 812 or miglyol 840, our process filter the oil before use. While natural oils may seem like a better solution for your needs, it is important to consider miglyol compounds because they are manufactured in a way that ensures stability and purity. They can also be more cost effective.
PSL Team Supervisor,
Vision
Yes it does matter for "some".. Carrier oils release at different rates, thus this will effect the serum levels of the parenting hormone, however the carrier really has little effect on a scale that you or anyone would even notice aside from its " kinetic profile under clinical investigation/studies" , although administration with certain carriers may yield different toxicological profiles for the same drug, some reaching supraphysiological serum testosterone levels, but this will vary with administered route (whether IM or subQ), different esters, individuals and so on..Also, different regions favor one oil over the other like western pharmacopoeia practice may often and commonly use Grape-seed, as in other regions of the world with therapies some use tea-seed oil,soy and cottonseed with the same promising returns (pro's and con's with both oils), much like Enanthate is manufactured in Europe for TRT, while Cypionate is manufactured in the U.S. Testosterone Cypionate and Enanthate both steroids have the same effects and functions, whilst there are studies claiming the longevity effect of Cypionate compared to Enanthate differ,but we know it's irrelevant on the small scale..The same can be seen and recognized with carriers to a degree, this is why most UGL's will use the same carriers to keep release time with-in a narrow range of others..
Now if we're talking about supraphysiological serum testosterone levels, with shorter esters in different carrier oils that possess different half-life/molecule weight (yes carrier half life's), with different routes of administration? Sure, we can see levels exceeding upper limits, but the extended release will balance out with a decline (ester dependent), this is just a quesstimation as there will be many variables to conciser (age,genetics) but you get the jist on the generalization here.
In the grand scheme of it all, It comes down to 90% allergies and oil-Viscosity..Site reaction,and immune response, and even hormone release (castor oil has a slow,stable,steady release for heavier esters due to its longer half-life)..However for most generally used carriers the viscosity really isn't that different when compared through kinematic viscosity measurement (mm2/s) - Fluid resistance..
When being measured they're off by a few digits, but that's so insignificant..It's mainly immune response/allergies/site irritation..
Below is a template of kinematic viscosity measurements (mm2/s) - Fluid resistance with most major carrier oils. Top being thickest, and last being thinnest..I hope this helps..
Castor 297.0
Crambe 53.6
High-Oleic Safflower 41.2
Peanut 39.6
Sunflower 37.1
Grapeseed 37.0
Sesame 35.3
Corn 34.9
Cottonseed 33.5
Soybean 32.6
Safflower 31.3
MCT 25-33
Here is a study explaining how "castor oil" has a longer half-life than most traditionally used carriers in general practice
Intramuscular injection of testosterone undecanoate for the treatment of male hypogonadism: phase I studies.
Behre HM1, Abshagen K, Oettel M, Hübler D, Nieschlag E.
Author information
Abstract
OBJECTIVE:
In the search for long-acting testosterone preparations suited for substitution therapy of hypogonadal men, testosterone undecanoate (TU) dissolved in either tea seed oil or castor oil was investigated.
DESIGN:
In study I, 1000 mg TU in tea seed oil (125 mg/ml) were injected in equal parts into the gluteal muscles of seven hypogonadal men. In study II, 1000 mg TU in castor oil (250 mg/ml) were injected into one gluteal muscle of 14 patients.
RESULTS:
In comparison with published data on testosterone enanthate, most widely used for i.m. injections, the kinetic profiles of both TU preparations showed extended half-lives and serum levels not exceeding the upper limit of normal. The castor oil preparation had a longer half-life than TU in tea seed oil (33.9+/-4.9 vs 20.9+/-6.0 days (mean pm S.E.M.)).
CONCLUSION:
The longer half-life and the smaller injection volume make TU in castor oil a strong candidate for further applications in substitution therapy and in trials for male contraception.
Abstract
In the search for long-acting testosterone preparations suited for substitution therapy of hypogonadal men, testosterone undecanoate (TU) dissolved in either tea seed oil or castor oil was investigated.In study I, 1000 mg TU in tea seed oil (125 mg/ml) were injected in equal parts into the gluteal muscles of seven hypogonadal men. In study II, 1000 mg TU in castor oil (250 mg/ml) were injected into one gluteal muscle of 14 patients.In comparison with published data on testosterone enanthate, most widely used for i.m. injections, the kinetic profiles of both TU preparations showed extended half-lives and serum levels not exceeding the upper limit of normal. The castor oil preparation had a longer half-life than TU in tea seed oil (33.9+/-4.9 vs 20.9+/-6.0 days (mean pm S.E.M.)).The longer half-life and the smaller injection volume make TU in castor oil a strong candidate for further applications in substitution therapy and in trials for male contraception.
Below is a great read about treatments, and serum levels with carrier oils!
Intramuscular injection of testosterone undecanoate for the treatment of male hypogonadism: Phase I studies
Last but not least let's talk about MCT oil?
All Euro-Pharmacies oils are all synthetic and made with the finest pharma grade vehicle oils on the market,
some of these same carries are used world wide in clinics all around the world to avoid lymphatic acute reactions,
absolute NO food derivatives in order to avoid site irritation or localize swelling for utmost comfort!
Sensitive info
With Euro-Pharmacies Oil based compounds - Absolutely NO EO-OIL is used or other food derivatives for carrier delivery method of all parenting hormones due to allergic reactions with some carries.
EP's oil base products are smooth with less site irritation like most other carriers, while providing a more stable and longer shelf life of the suspended drugs.
EURO-PHARMACIES MANUFACTURING METHODS , SUPPLIES , SEMI PRODUCTS AND ALL OPERATING ELEMENTS ARE COMPLETELY/CONSTANTLY UP TO DATE WITH ALL THE LATEST GLOBAL STANDARDS.
1. Carrier Oils used in EP Injectable Products Line manufacturing processes are completely Pharmaceutical Grade.
100% Synthetic , Hypoallergenic and Completely Clear/Transparent in terms of Color properties.
(No tint- No impurity and Completely Infection/Contamination Proof)
A. Hormone Raw Materials batches applied in production processes Can Naturally differ in Color Tint Properties
Therefore it's sometimes possible that some particular EP Line Product Batches can differ in terms of color tint rate.(Due to 100% Clear - Transparent Carrier Oil Appearance Property)
2. Solely Pharmaceutical Grade Hormone Raw Materials used in EP Injectable Products Line manufacturing processes.
(Provided only by Official and Certified Pharmaceutical Manufacturers)
3. Solely Pharmaceutical Grade Hormone Raw Materials used in EP Oral Products Line manufacturing processes.
A. Professional and HIGHEST QUALITY Fillers applied to EP Oral Products Line. (ie. starch , PVP etc.)
More info
EP Line Crystal Clear|Pro. Carrier Oils Clarification
Original EP Line always used only Professional/Legit Pharma Grade Carrier Oils "Inside".
EP Line PG carrier Oils were SOLELY Created and Produced for "PG" AAS.
Of course products like Deca and all Trens are an exception clearly - due to their "essence" used ...
EP Line uses only Pharma Grade carrier oils (synthetic/hypoallergenic/smooth/most efficiently dissolved-merged with the "essence" - professional oil used only in Original Pharm. Grade Products)
No UGL on the market uses such Pro./Expensive Oils to our knowledge.Those carrier oils are available only to Legit/Registered Pharma Grade Manufacturers ... and to Us.
(We sincerely apologize if we EVENTUALLY missed anything on any UGL on the market about that matter)
EP Line carrier oils proved with 100% certainty:1. Second to None - Highly smooth and Painless injection experience.
2. Body/System 100% Smooth & Effective applicability and response.
3. 100% Pharma Grade Feature of: dissolving/applying with the "essence" in the system/body right from the start.
EP Line "Essence" Origin and Quality matches those PG Carrier Oils Fully naturally.
What is Miglyol 812?
Miglyol 812 is also a clear neutral oil. Miglyol 812 is a liquid form of an MCT oil. An MCT oil is a medium-chain triglyceride. A medium-chain triglyceride is a man-made fat that that is partially manmade. It is identified by the way the carbon atoms are rearranged in the structure. Many people use MCTs, which are typically derived from coconut and palms oils and dairy fats, for improved diet and weight management.
According to the Cleveland Clinic, MCTs decrease metabolic syndrome, reduce abdominal obesity, and boost weight loss. Like miglyol 840, miglyol 812 is desired in toxicology and pharmaceuticals because it improves the solubility and absorption of injectables and oral compounds. Miglyol is soluble at 20 degrees Celsius. Additional properties of miglyol 812 are spreadability, penetration-promoting application, and high stability compared to natural oils. When used as a lotion, cream, or any other spreadable application, miglyol 812 is permeable and non-greasy; therefore, it does not obstruct the skin’s natural respiration.
Whether we use miglyol 812 or miglyol 840, our process filter the oil before use. While natural oils may seem like a better solution for your needs, it is important to consider miglyol compounds because they are manufactured in a way that ensures stability and purity. They can also be more cost effective.
PSL Team Supervisor,
Vision
