CJC-1295 and MK-677

[STTM]

Just curious to see if any of you guys have tried this combination. I know CJC with DAC is frowned upon because it causes GH to "bleed" instead of "pulse". Pinning the no DAC version 2-3 times a day just isn't convenient for me. Was thinking that the MK-677 would work well with it. Looking at running 4mg a week of CJC, and 25mg a day of MK-677.

If no one one has ran these together, it would be cool if you could give me your opinions on them separately. Pro and Cons, and if you would run them again.

Thanks guys.

 

[Elvia1023]

Just curious to see if any of you guys have tried this combination. I know CJC with DAC is frowned upon because it causes GH to "bleed" instead of "pulse". Pinning the no DAC version 2-3 times a day just isn't convenient for me. Was thinking that the MK-677 would work well with it. Looking at running 4mg a week of CJC, and 25mg a day of MK-677.

If no one one has ran these together, it would be cool if you could give me your opinions on them separately. Pro and Cons, and if you would run them again.

Thanks guys.

I have never tried MK-677. But CJC-DAC I have tried It's my fav peptide. I could talk about it for hours haha. That bleed thing is nonsense in a sense. Guys say it mimics women's gh etc and you want to it to be in spikes like men naturally have. But when as natural and the best results ever gone together. I should add though it is hard work for your pituitary gland so common sense needs to be used. You cycle it on and off with long breaks.

4mg cjc-dac each week will give incredible results. The fat will melt off you and your muscles will constantly feel full. It as a long half life so it's convenient too. I know many who do it everyday but I prefer twice weekly dosing (2mg x 2). I have a thread on cjc-dac with an article I wrote in the sticky section. Plus I have a log on here too but I could only get 2mg per week but even at that dose the results are great.

If you decide to run it get some huperzine a tabs from ebay etc as that will make it more effective as it's acts as an acetylcholineesterase inhibitor. Green tea is also great to have when using cjc-dac as that can block it too.

 

[Elvia1023]

Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.

Teichman SL1, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA.
Author information

• 1WinPharm Associates, Alamo, CA 94507, USA.

Abstract

CONTEXT:

Therapeutic use of GHRH to enhance GH secretion is limited by its short duration of action.
OBJECTIVE:

The objective of this study was to examine the pharmacokinetic profile, pharmacodynamic effects, and safety of CJC-1295, a long-acting GHRH analog.
DESIGN:

The study design was two randomized, placebo-controlled, double-blind, ascending dose trials with durations of 28 and 49 d.
SETTING:

The study was performed at two investigational sites.
PARTICIPANTS:

Healthy subjects, ages 21-61 yr, were studied.
INTERVENTIONS:

CJC-1295 or placebo was administered sc in one of four ascending single doses in the first study and in two or three weekly or biweekly doses in the second study.
MAIN OUTCOME MEASURES:

The main outcome measures were peak concentrations and area under the curve of GH and IGF-I; standard pharmacokinetic parameters were used for CJC-1295.
RESULTS:

After a single injection of CJC-1295, there were dose-dependent increases in mean plasma GH concentrations by 2- to 10-fold for 6 d or more and in mean plasma IGF-I concentrations by 1.5- to 3-fold for 9-11 d. The estimated half-life of CJC-1295 was 5.8-8.1 d. After multiple CJC-1295 doses, mean IGF-I levels remained above baseline for up to 28 d. No serious adverse reactions were reported.
CONCLUSIONS:

Subcutaneous administration of CJC-1295 resulted in sustained, dose-dependent increases in GH and IGF-I levels in healthy adults and was safe and relatively well tolerated, particularly at doses of 30 or 60 microg/kg. There was evidence of a cumulative effect after multiple doses. These data support the potential utility of CJC-1295 as a therapeutic agent.

 

[John Juan]

CjcDAC is frowned upon by this who haven't tried it and merely regurgitate what they've read. CjcDAC is one of the most amazing peptides for fat loss, constant muscle fullness, and enhanced recovery. GH bleed may not mimic the bodies natural pulses but you still get a dozen gh pulses while using DAC. CjcDAC does NOT stop the pituitary gland from pulsing. Studies prove that. Constant GH bleed is similar to synthetic HGH as gh is present for an extended amount of time.

 

[Elvia1023]

CjcDAC is frowned upon by this who haven't tried it and merely regurgitate what they've read. CjcDAC is one of the most amazing peptides for fat loss, constant muscle fullness, and enhanced recovery. GH bleed may not mimic the bodies natural pulses but you still get a dozen gh pulses while using DAC. CjcDAC does NOT stop the pituitary gland from pulsing. Studies prove that. Constant GH bleed is similar to synthetic HGH as gh is present for an extended amount of time.

Exactly. Although add Huperzine A and it's a little different.

JJ has just started cjc-dac too. We basically copied eachothers cycle so I am doing LR3 and a few other bits soon

 

[STTM]

CjcDAC is frowned upon by this who haven't tried it and merely regurgitate what they've read. CjcDAC is one of the most amazing peptides for fat loss, constant muscle fullness, and enhanced recovery. GH bleed may not mimic the bodies natural pulses but you still get a dozen gh pulses while using DAC. CjcDAC does NOT stop the pituitary gland from pulsing. Studies prove that. Constant GH bleed is similar to synthetic HGH as gh is present for an extended amount of time.

Sounds great. Thanks for the input on this.

What are your thoughts on adding MK-677 with it?

 

[Elvia1023]

I had 3 vials of cjc-dac left so I dosed 1 vial (2mg) on Tues and will do again this Fri and next Tues. On Tues night I dosed it with 0.3mg prami and 83mcg GHRP-2 and I woke up and my hands were throbbing. Literally completely numb... more so than when I tried 10IU Riptropin. It's only a side effect but in the past when I have upped my dose or added something (gh related) my hands are more numb the next day so there is definitely a correlation between numbness and GH release with me.