Benzyl Alcohol Allergy and Respitory Reactions

[Genetic1der]

I have some info and a question.


INFO:
Use in Health Care
Benzyl alcohol is used as a bacteriostatic preservative at low concentration in intravenous medications. It is oxidized rapidly in healthy individuals to benzoic acid, conjugated with glycine in the liver, and excreted as hippuric acid. High concentrations can result in toxic effects including respiratory failure, vasodilation, hypotension, convulsions, and paralysis. Newborns, especially if critically ill, may not metabolize benzyl alcohol as readily as adults. Reports in the early 1980's of sixteen neonatal deaths associated with the use of saline flush solutions containing benzyl alcohol preservative led to recommendations to avoid its use in neonates.

Other research I have done like the following Medical Toxicology book:
Medical Toxicology By Richard C. Dart, E. Martin Caravati
page 1232

also seem to agree that this product can and does cause lung/respitory problems.

It does also note however that it must be in high doses and affects some individual more than others. There is no antidote for overdose.


Question:

Does anyone here have any first hand experience with a product called POSILAC.

thanks,

 

[eddymerckx]

how are your two points connected? is there a high concentration of BA in bovine growth hormone?

 

[Genetic1der]

the two points are not connected. I did want to contribute as well as learn. Therefore I gave to get.