Hola,
Si usas AAS que aromaticen, el exemestano es el inhibidor más indicado:
(1) Only exemestane induced a residual inhibition of aromatase activity after its removal, without any change in the aromatase protein level.
Cualquier otro inhibidor de la aromatasa regula al alza la aromatasa cuando dejas de usarlo, causando un rebote en el nivel de estrógenos.
La acción del exemestano sobre la aromatasa es irreversible, por lo que este rebote estrogénico es imposible.
(2) Suppression of estrogen, via estrogen receptor or aromatase blockade, is being investigated in the treatment of different conditions. Exemestane (Aromasin) is a potent and selective irreversible aromatase inhibitor. To characterize its suppression of estrogen and its pharmacokinetic (PK) properties in males, healthy eugonadal subjects (14–26 yr of age) were recruited. In a cross-over study, 12 were randomly assigned to 25 and 50 mg exemestane daily, orally, for 10 d with a 14-d washout period. Blood was withdrawn before and 24 h after the last dose of each treatment period. A PK study was performed (n = 10) using a 25-mg dose. Exemestane suppressed plasma estradiol comparably with either dose [25 mg, 38% (P 0.002); 50 mg, 32% (P 0.008)], with a reciprocal increase in testosterone concentrations (60% and 56%; P 0.003 for both). Plasma lipids and IGF-I concentrations were unaffected by treatment. The PK properties of the 25-mg dose showed the highest exemestane concentrations 1 h after administration, indicating rapid absorption. The terminal half-life was 8.9 h. Maximal estradiol suppression of 62 ± 14% was observed at 12 h. The drug was well tolerated. In conclusion, exemestane is a potent aromatase inhibitor in men and an alternative to the choice of available inhibitors. Long-term efficacy and safety will need further study. .
(1) - Comparison of In Vitro Exemestane Activity Versus Other Antiaromatase Agents -
http://www.electronicipc.com/journalEZ/detail.cfm?code=39560010015113
(2) - Pharmacokinetics and Dose Finding of a Potent Aromatase Inhibitor, Aromasin (Exemestane), in Young Males - Nelly Mauras, John Lima, Deval Patel, Annie Rini, Enrico di Salle, Ambrose Kwok and Barbara Lippe -
http://jcem.endojournals.org/cgi/content/full/88/12/5951
En el caso de una ginecomastia, lo lógico sería Nolvadex.
Salu2