Gloveg, lo que tienes ahi es un anti-progestin no un anti-estrogeno. La forma es que trabaja es mediante el bloqueo de receptores de progesterona ya que el Danazol es en si una progestina debil.
Nunca la e usado pero aqui te tengo un articulo. Si quieres que te lo tradusca lo hago con mucho gusto:
Danazol:
An isoxazole derivative of ethisterone (17alpha-ehtinyl testosterone) with weak progestational and androgenic activities, is used to suppress ovarian function. Danazol inhibits the midcycle surge of LH and FSH and can prevent the compensatory increase in LH and FSH following castration in animals, but it does not significantly lower or suppress basal LH or FSH levels in normal women. Danazol binds to androgen, progesterone, and glucocorticoid receptors and can translocate the androgen-specific RNA synthesis. It does not bind to sex hormone-binding globulin (SHBG) and corticosteroid-binding globulins (CBG). It inhibits its p450scc, but does not inhibit aromatase. It increases the mean clearance rate of progesterone, probably by competing with the hormone for binding proteins, and may have similar effects on other active steroid hormones. Ethisterone, a major metabolite, has both pogestational and mild androgenic effects.
Danazol is slowly metabolized in humans, having a half-life of over 15 hours. This results in stable circulating levels when the drug is administered twice daily. It has been found to be highly concentrated in the liver, adrenals, and kidneys and is excreted in both feces and urine.
Danazol has been employed as an inhibitor of gonadal functions and has found its major use in the treatment of endometriosis. For this purpose, it can be given in a dosage of 600 mg/day. The dosage is reduced to 400mg/day after 1 month and to 200mg/day in 2 months. About 85% of patients show marked improvement in 3-12 months.
Major adverse effects are weight gain, edema, decreased breast size, acne and oily skin, increased hair growth, deepening of the voice, headache, hot flashes, changes in libido, and muscle crapms. Although mild adverse effects are very common, it is seldom necessary to discontinue the drug because of them.
Danazol should be used with great caution in patients with hepatic dysfunction, since it has been reported to produce mild to moderate hepatocellular damage in some patients, as evidenced by enzyme changes. It is also contraindicated during pregnancy and breast feeding, as it may produce urogential abnormalities in the offspring.
It is under the heading ESTROGEN & PROGESTERONE INHIBITORS AND ANTAGONISTS grouped with Tamoxifen (nolvadex) Clomiphene, Mifepristone.
IB
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