Re: ANDROSTENEDIOL REVISITED

Subject:

Comments:
: : : : : : QUESTION FOR THE PRO'S (UNIQUE,HULKSTER, ANIMAL ETC) : : : : : : I saw the previous postings about conveting DHEA to : : : : : : methandriol to methyltest. Did the recipe ever get : : : : : : posted??? Inquring muscles want to know... Has anyone : : : : : : had any success with the conversions? : : : : : : : : : : Maybe I have at one time. Methyl grignard reaction followed by hydrolysis and get rid : : : : : of the excess unreacted ketone with semicarbazide HCl. Then oppenauer oxidation : : : : : with Aluminium isopropoxide in toluene with cyclohexanone at reflux to get methyltest. : : : : : Workup of the oppenauer reaction is not easy though. : : : : : : : : : : : : : : PA : : : : : : : : : : if so where can : : : : : : I get the post(recipe) Also, Would it be better to : : : : : : prepare a DMSO solution of ANDOSTENE 50 instead of : : : : : : ingesting it? : : : : An alternative reaction would be to take DHEA, treat it : : : : with trimethylsulphonium iodide, separate out the tetrhydropyranyl ether : : : : via thin layer chromatography and reduce the latter via lithium : : : : aluminum hydride to methandriol--which can be oxidized via oppenauer to : : : : 17-meth. Of course, Pat's way of treating the DHEA with methylmagnesium : : : : bromide is a little easier. : : : : Keep up the fight : : : : Unique : : : No offense unique but your method makes little sense. Trimethylsulphonium iodide is not used : : : to make tetrahydropyranyl ethers. And LAH will reduce the 17 ketone to a secondary alcohol. : : : Where is the 17 methyl coming from? Or perhaps you meant methyl lithium instead of LAH? : : : And I think you were thinking of androstenedione as the starting material. If the conjugated 3-ketone : : : were protected (either as an enamine, enol ether etc.)then methyl lithium could be used to react at 17 C=O : : : : : : : : PA : : Pat, what are you even talking about? The above is a very common way of producing both methandriol and : : methytest. Methyllithium--HUH? Androstenedione--HUH? Dude, the trimethylsulphonium iodide will give : : a mixture of 17B,20-eopxy-21-norpregn-5-en-3B-ol and its methyl ether--ie the tetrahydropyranyl. The ether : : is reduced with LAH and then hydrolyzed (whoops, I missed this step, sorry!). It works and it's basic : : organic, steroid chemistry. : : Keep up the fight : : Unique : Well its a new one to me and I thought I was up on this. If you could provide a reference : I would be very appreciative : PA

Optional Link URL:
Link Title:
Optional Image URL: