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Three new top bodybuilding drugs - Melanotan II, Hexarelin, and IGF-1 LR3. Enjoy!
Melanotan II
Melanotan II is an analog, or a peptide hormone known as alpha-melanocyte stimulating hormone (a-MSH) that tends to induce skin tanning. Melanotan II has the added effect of increasing libido, and doesn't just tan the skin.
Administering this hormone to the body directly is probably an effective method to cause “sunless tanning” or chemically induced tanning. There are no obvious toxic effects of Melanotan II and, in fact, because skin cancer is a major health concern, it may actually be able to combat it to a degree. This is because Melanotan II stimulates the body's natural tanning mechanism (Melanin) to create a tan without needing the stimulus of direct sunlight. This can reduce skin damage as a result of exposure to the Sun’s rays, that can eventually lead to skin cancer. Melanotan II would therefore seem to be a safe way to effectively tan without being exposed to the Sun.
In addition, Melanotan II also has demonstrated aphrodisiac properties. It would seem that this compound, when administered, is transformed into a metabolite which has potent aphrodisiac and let's just say it will really put lead in your pencil.
Melanotan is popular with athletes and fitness enthusiasts who wish to have the look of a tanned body, but would rather not expose themselves to the potentially harmful rays of the Sun.
Hexarelin
Hexarelin is a synthetic hexaptide which has GH-releasing properties. Hexarelin, administered subcutaneously produces a dose-dependent GH response from the Pituitary.
The advantages of having GH secreted in larger amounts in the body would be similar to what happens when injectable growth hormone is administered. Effects from GH include increased bone mineral density, increased mitosis and meiosis which leads to more muscle mass, triglyceride hydrolysis which causes prominent fat loss, connective tissue strengthening, and improved skin elasticity.
GH secretion also leads to the liver secreting more IGF-1 (Insulin-Like Growth Factor One), which by itself has a host of effects similar to GH. Users of IGF-1 typically experience increased strength and muscle mass, as well as a very pronounced fat loss.
Therefore, by injecting Hexarelin, the user will experience all of the effects of both Growth Hormone as well as IGF-1. However, since Hexarelin actually stimulates the body to produce more GH, it may be likely that the eventual shutdown of the body’s natural GH production may be avoided, as is seen with injectable GH. For this reason, many athletes use Hexarelin alone, but others have used it after a Growth Hormone or Insulin-Like Growth Factor one cycle, to “jumpstart” their own natural GH and IGF-1 production.
IGF-1 LR3
IGF1 is a peptide roughly the same structure and size as insulin, or about 70 amino acids long. It belongs to the peptide family of substances identified as growth factors. It is a highly anabolic hormone released in the liver as well as in peripheral tissues such as skeletal muscle. In the body, IGF-1 is released in response to the presence of Growth Hormone (GH). After intense resistance training, the body experiences a surge in GH and IGF, and this is one way that new muscle is built. Although GH is considered to be highly anabolic, in actuality, IGF-1 is suspected to be responsible for the primary anabolic activities of GH.
IGF-1 builds new muscle tissue by promoting nitrogen retention and protein synthesis. This causes the growth of muscles through both hyperplasia (which is an increase in number of muscle cells) and mitogenesis (which is the actual growth of new muscle fibers). Thus IGF-1 not only makes muscle fibers bigger, it makes more of them as well
IGF-1’s effects are not limited to building new muscle, however. It has a potent effect on lipid (fat) metabolism, and helps the body burn fat at a significantly elevated rate. In addition, IGF-1 is both a neuroprotector and neuropromotor, which improves mental functions such as reflexes, memory, and learning ability. IGF is also important for production of connective tissue and insuring proper bone density.
Although IGF-1 is very potent at building muscle and burning fat, the Lr3 IGF-1 version is roughly 2-3x as powerful.
Lr3IGF-1 (Long R3 Insulin-like Growth Factor-I or Long R3IGF-I) is an 83 amino acid analog of human IGF-I actually comprising the complete human IGF-1 sequence but with the substitution of an Arg for the Glu at position 3, as well as a 13 amino acid extension peptide at the N-terminus. This makes Long R3IGF-I significantly more potent (2-3x) than IGF-I in studies, because it has a lower affinity to be rendered inactive by IGF binding proteins, and consequently more potential activity in the body.
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