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To serious bodybuilders and athletes, the idea of buying fitness in a pill or bottle is laughable at best. For me, the mere thought conjures up images of some chubby, middle-aged man who can't pull himself away from an Ice Road Truckers marathon long enough to do a single push-up - yet still thinks that he can get fit just by using a product.
The fitness industry has played guys like this for years while selling billions in supplements. Luckily, most of us aren't like this guy and know that products alone won't make you ripped. But if there's anything I've seen that comes remarkably close to fitness in a bottle, it's the compound known as GW-1516.
Also called GW501516 or Cardarine, GW-1516 greatly intrigues researchers due to its ability to significantly increase endurance and burn body fat in test subjects. No, this isn't just some B.S. fat-burning compound that you find on Walmart shelves, but rather the real deal. In fact, GlaxoSmithKline once thought that this drug could be the cure for diabetes, obesity and cardiovascular disease. Despite seeing great results during trials, GSK chose to stop trialing the drug, which we'll discuss later. But first, let's dive further into how GW-1516 works and cover some of its amazing benefits.
How GW-1516 Dramatically Cuts Fat and Improves Athletic Performance
GW-1516 is a selective activator of the PPARD (Peroxisome proliferator-activated receptor delta) gene, which is involved in the building and regulation of muscle. When the PPARD is activated, it helps develop more slow-twitch muscle fibers and shifts the body's metabolism to burn fat for fuel, rather than sugars or muscle. The end result is that test subjects can cut fat while exercising without simultaneously losing muscle mass.
Studies performed by Ronald M. Evans and Salk Institute showed that GW-1516 helped mice shed weight even when they were on high-fat diets. Additionally, the drug caused the rodents to put on muscle mass as well.
Not only were the mice gaining muscle and losing fat, but their endurance also increased quite a bit. The Salk Institute researchers used GW-1516 in combination with the AICAR peptide to create a synergistic effect. Both drugs already have excellent effects on endurance when used in isolation. However, when used together they helped mice run 44% further than their non-dosed counterparts.
Obviously it can be seen that GW-1516 has some very positive effects on test subjects. Assuming you're interested in using this compound for research purposes, I highly recommend that you try SuperiorPeptide.com. They offer the best quality peptides and research liquids on the market, and their service is excellent.
Now, before we move on, here's a recap of the GW-1516 benefits:
- Shifts metabolism to burn fat for energy, instead of carbs or muscle
- Fights obesity, even on high-fat diets
- Increases endurance
- Delivers an incredible endurance boost when combined with AICAR
- Staves off cardiovascular disease
- Can increase lean muscle mass
Highly Popular among Athletes
Some athletes and bodybuilders have chosen to use themselves as GW-1516 test subjects. Champion Russian cyclist Valery Kakov is one of the more famous examples since he was suspended from competition in 2013 after testing positive for GW-1516. Just one week after Kakov's positive test, four professional Costa Rican cyclists were suspended for using the drug to improve their endurance.
Before 2009, there was no reliable test for GW-1516. This caused widespread concern before the 2008 Beijing Olympics regarding athletes using the compound to gain a major edge. A researcher was able to develop a reliable urine test, though, and the World Anti-Doping Agency subsequently banned the drug.
Not everybody who uses GW-1516 is a professional and/or Olympic athlete. A quick look across many bodybuilding forums will show you that the compound is very popular among recreational users. Multiple logs from bodybuilders have shown a sharp decrease in body fat, increased endurance and strength, and a better overall physique with few side effects. But again, it's recommended that those purchasing GW-1516 stick to research purposes only.
GlaxoSmithKline Controversy
After GSK cleared GW-1516 for use through pre-clinical studies, they began dosing humans in trials. The compound passed two Phase II clinical trials, producing some very successful results along the way.However, GSK was also using the drug on rats and noticed that it rapidly caused cancer in the rodents. Following this discovery, GSK scrapped their trials.
Since then, GSK's studies have come under scrutiny because they used 100 times the average human dosage on mice. Furthermore, the creatures were dosed for 104 straight weeks, which is far longer than any normal study involving the drug.
GW-1516 Dosage
A good recommended starting dosage when administering GW-1516 to test subjects is 5mg a day. Experienced subjects may get more benefits from 10mg daily dosages. As for cycling the drug, a 2 to 3-month cycle is generally advised during studies.
PS here are some related links to discussions about GW and AICAR on the EliteFitness.com forums:
3. Gw501516
5. Any one Cutting FAT using GW501516 and Aicar
6. Aicar + gw ?
7. Aicar