Gene Variation Means Some Juicers Cannot Get Busted

Steroid users and juicing athletes have tried tons of things for years to avoid getting caught by sports governing bodies and authorities. But a new study shows that if any of them had this genetic variation they would not have to worry about ever getting caught using roids again.

Let me start this off by briefly going through a few of the ways that athletes and others have tried to help themselves beat steroid tests:

Diuretics: One way that athletes attempt to beat testing for roids is by using diuretics. Basically, these are used to dilute urine as they increase water excretion. The problem with this is that one’s specific gravity will be lower once they use diuretics making it more likely to show up in their urine. This means all a tester has to do is employ a specific gravity test on a person making diuretics a very bad way to avoid getting caught.

Blocking Agents: These are drugs that athletes use because they think blocking agents will allow them to keep juicing right up until their competition takes place. The truth is though that drugs like Probenecid aren’t as effective at masking steroids and, even if they were, most blocking agents show up on drug tests too.

Catheterization: Of all the extreme, and most painful, ways that an athlete could use to beat a steroid text, this one ranks at the top. Catheterization involves shoving a tube through the urethra to the bladder and emptying the dirty (steroid-filled) urine. After this is done, a person then puts clean urine back into their body like seen in the old football movie “The Program”. This method can work but problems include that it isn’t 100% effective and catheterization can very dangerous because infection could arise during the process.

Cycling: This is by far the most effective way to beat steroid testing as a user juices during their off-season and quits closer to competition time. This ensures that they get a lot of the benefits steroids provide during training and don’t get caught. However, the downside is that some of the gains will be lost after going off roids and, even with cycle and half-cycle guidelines laid out for most drugs, there are no guarantees that all of the steroids will be out of one’s system come testing time.

As you can see, these ways of trying to beat steroid testing are both not always effective and sometimes dangerous. That’s why steroid users and athletes still look for ways to beat the tests while testers are always finding new ways to combat those who break their rules. And in the end, it seems like the testers are often the ones who win out.

However, there is no winning for steroid testers in a new development that has Olympic officials extremely scared that the Beijing event will be tainted. And other sports governing bodies are also worried that people will be breaking their rules if things come to pass.

A study done at Sweden’s Karolinska Institute has revealed that people who lack the gene known as UGT2B17 can effectively use testosterone all they want and not have it show up on a drug test. And this might not seem like a very big deal at first as most would write it off as some freak of nature thing where only a small percentage of people would lack the UGT2B17 gene. But in reality the Karolinska Institute study revealed a lot bigger problem for worried testers.

In the study, scientists at the Karolinska Institute researched 55 men and injected them all with the same amount of testosterone. The scientists then checked the men regularly over a 15 day period for high levels of testosterone. Six days after the 15 day period (when testosterone levels peaked) the athletes were tested for testosterone levels to see if they were high enough to be detected on a drug test.

When the results were in, a full 100 percent of the men who had the UGT2B17 gene tested high enough to fail a testosterone drug test. On the contrary, 41 percent of the men who lacked the UGT2B17 gene easily passed the test while some of the other 59 percent had levels under the what the people who had the gene possessed.

So what’s the reason for why people who don’t have the UGT2B17 gene did so much better on the tests than those who do have it? Well according to one of the researchers at the Karlolinska Institute named Jenny Shulze there is a very good reason for why this is so. She said, “Genetic factors may play an important role in the accuracy and sensitivity of testosterone doping tests. If you don’t have the gene you don’t secrete testosterone in your urine.” Shulze went on to say that, “Nearly half of the individuals in our study who carried this genetic variation would go undetected in a regular doping test.”

Besides the simple fact that people who are lacking this gene can go undetected in a drug test, another interesting thing to point out is that race weighs in heavily on who actually has the gene and who doesn’t. In other words, there is one particular race that is very susceptible to not having the UGT2B17 gene.

According to the researchers, the lack of this gene is actually pretty rare among Caucasians and African Americans as less than 10 percent of these races are missing it. On the other hand, Asians who live in Korea, China, and Japan lack the UGT2B17 gene an astounding 65 percent of the time.

Shulze claims that despite the race disparity Olympic officials and other sports authorities will probably still be alarmed by the numbers. She mentioned, “When you talk about genetic variations, 10 percent is still quite a high number.” And she’s probably right as positive testosterone tests make up over 43 percent of the overall positive drug tests during the Olympics.

One very notable athlete that was busted for testosterone and has to sit out the Beijing Olympics is Justin Gatlin. Gatlin won the most heralded Olympic event in the 100 meters at Athens and also won the 2005 World Championship 100 meters and 200 meters. And it’s almost a foregone conclusion that many more will join him in suspension, and possibly have their medals revoked like Marion Jones, after the 2008 Beijing Olympics.

But the question is who will be getting away with using performance enhancing drugs like testosterone and who will be walking away unscathed from the mess just because they lack a certain gene. My guess is that the news of this research will already have athletes checking to see if they have the gene and, consequently, if can get away with using testosterone in the future.

But once again, Jenny Shulze has her own opinion as she believes there may be a way to catch more people who lack the UGT2B17 gene and use testosterone. She stated, “Genotyping as a complement to the conventional urine analysis would improve the sensitivity of the test.”

Still, this would be a pretty complicated process and, like some of the ways juicers use to beat steroid tests, it would be very controversial too. In the end though, I’m not really so concerned about what athletes or Olympians do to cheat steroid tests or gain a competitive edge in the field. I’m a lot more concerned about people being able to legally use steroids for their own personal gains.

However, the problem is that stories like people missing the UGT2B17 gene and being able to take testosterone or athletes using steroids to set world records makes roids synonymous with cheating. And since they become synonymous with cheating, people don’t look at steroids for what they are and that is drugs used to build muscle.

They can be used responsibly or can be abused and the choice is really up to the user themselves. But one thing is for sure and that is our rights are being abused in that we can’t legally juice without worrying about being looked down upon by the law and media.

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