Scientist Andy Dillin discovers the longevity fountain of youth with the PHA-4 gene while researching cures for Alzheimer’s Disease

There is a team of scientists that are closing in on the secret to keeping your youth over the span of your whole life. And the amazing thing is this new drug they are working on is said to even have the potential to double a person’s life span and take care of incurable diseases too!

We’ve all heard the old phrase, “Age is just a number.” But try approaching the 21 year-old hottie at the club with that line when your goatee and hair are generously decorated with white and gray speckles. Let’s just be honest, feel good lines like these aren’t going to cut it with the babes.

So what are we to do when we grow older and the girls we desire stay the same age? And what of other areas of life? Women aren’t the only thing to worry about as our bodybuilding and weightlifting performances can drop off as well once we are past our peak age ranges. So do we all just crawl off to the retirement communities of Florida to die off?

Not according to Andy Dillin, who is considered by many to be the best young scientist in the world. Dillin believes that one day in the near future we can, as he says, change the aging program. And what fascinates people the most is that he and his lab mates at Salk Institute in La Jolla, California may hold the key, or single drug, that could extend people’s youthfulness well into their later years and even double their lifespan. But before this can even be fathomed, we must go back to the beginning...

It all began with a worm. Not just any worm though. It was a worm that was part of a cell development project engineered by future Nobel Prize winner Sydney Brenner. However, this worm, named C. elegans, was still a worm nonetheless. But to University of California at San Francisco scientist Cynthia Kenyon, C. elegans was the worm that was going to change the way people thought about aging forever.

In the early 90’s, Kenyon mutated one of C. elegans genes and amazingly doubled the worm’s life span. This was an incredible feat considering she only changed one gene and this should have been huge news. But the exceptional experiment never really reached the mass public’s ears. It did however reach Andy Dillon’s as he got to work up close with Cynthia Kenyon years down the road and was enamored with the fact that she changed a living creature’s life span with rudimentary genetics.

Dillon was so obsessed with this finding that he set out to discover how Kenyon’s gene mutation actually worked and didn’t care how long it took as he said, “I wanted to find out how it specifically affected longevity and if it could affect longevity without affecting the other things. I figured it would take my entire career as a scientist.”

The incredible thing though is that he was able to accomplish this in just three years as he hit upon the gene that helps animals on diet restriction live longer. Basically, science had already known that animals who eat less than those who pig out live longer so, at first glance, there was no big deal here. But when Dillon put this gene, called PHA-4, out of commission it rendered diet restriction useless in regards to longevity and, when turned up, also made dieting unneeded. So eating tons of food no longer affected life span.

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This wasn’t all Dillon was discovering at the time as he found out that extending the life of his lab worms also gave them immunity to Alzheimer’s Disease. Due to the tweaking of the cellular functioning in the worms, this process was super-charged and became the preventer of Alzheimer’s Disease. Dillon noted this stunning achievement along with his findings on the PHA-4 gene in three separate papers he wrote.

And while the results of his work are fascinating, people could easily point to the fact that a worm is nothing like a human. Not in appearance, eating habits, daily functions, or really anything. Anything, that is, except for the longevity gene associated with dieting and their longevity proteins, which are essentially the same.

All of this leads us back to the point where Andy Dillon and his lab are holding the drug that could one day become the so-called fountain of youth. The point where Andy has yet to write a paper about.

Dillon’s lab workers had been working on a drug that would enable him to study the effects of the genes without changing them, which can’t be undone. What they ended up discovering, after testing thousands of compounds, was that one of them not only prevented Alzheimer’s better than mutating genes but also extended the worms’ lives. This prompted Salk Institute to have the compound altered so they could claim it as property and this is where the drug now stands.

What amazed Dillon so much about this drug that Salk Institute holds is that it can do so much yet is so simplistic. As he said, “I always thought that it was going to take a combination of drugs to increase life span. But the new drug is just a single compound, and it works so good.”

The theory of the way this drug is able to attain the desired effect of stopping Alzheimer’s is simple; limit the root cause of the disease caused by A-Beta toxicity. A-Beta throws cell proteins off and makes them misfold. But Dillon’s thinking is that the drug doesn’t block A-Beta so much as it promotes proper protein folding and youthfulness, or as he stated, “The essence of youthfulness is accuracy and precision of protein folding.”

He went on to say, “One drug. The dream is to develop one drug for diabetes, cancer, congestive heart failure, and Alzheimer\'s. You won\'t die of these things. You\'ll die at the end of your span. You\'ll die after you\'ve lived your life. It sounds science-fictiony, but we\'ve already done it in animals.”

By “span” Dillon means that the prime of people’s life will be lengthened so that there won’t be old age or diseases but rather their bodies just finally timing out. However, this is all just scientific speculation and what if he is wrong? “If I\'m wrong, people will be living to 250.” he said.

250!? And only if he is wrong! The mere mention of this thought brings some serious moral and ethical questions to mind right off the bat. The most imperative one being about overpopulation as humans are already reproducing at an alarming rate. If people are living to 250, and with the current population is steadily creeping towards 7 billion now, then how many billions will there be if this drug really works?

Dillon has already thought about this kind of stuff to himself plenty of times.

“Should we change the aging program in humans?” he pondered. “I can\'t make that decision. There has to be a regulatory body somewhere down the road that will make that decision. I have to believe that I\'m doing this for age-related disease, and I have faith that there will be regulation later on.”

Dillon went on to say, “You see, we\'re not getting pushback right now, because we can\'t do it yet. We don\'t have something in mice that says, hey, look what we can do. But we will probably be able to show that the drug we have up regulates longevity, and that puts us on a slippery slope.”

He also cleared up the marketing of the drug saying, “I mean the information will get out. Hey, this Alzheimer\'s drug, I mean, look what happened with Viagra. It was a heart drug. But guys who took it couldn\'t lay down on the beach. Now there are all these guys in La Jolla, seventy years old, dating girls my age. Viagra cut into my pool. All these baby boomers….they\'ve been f---ing my generation since we were born. Now they\'ve broken into the reproductive pool.”

Whether the ethics of the drug make sense or not, it looks as if Dillon and his team will continue to march on in their quest for a working Alzheimer’s (or possibly longevity) drug. But when, or if, it ever becomes available is largely a question mark. It’s hard to see the government allowing the average person to get their hands on a drug that could hurl the world as we know it into an entirely new existence. I mean just imagine it: a 200 year-old entering the before mentioned club scene and hitting on the 21 year-old chick. Now there’s an age difference!

But don’t ever expect this humorous little fantasy to happen without a fight. Many governments won’t even allow us to use drugs to enhance our muscles. Why would they let us have one that would help us live centuries beyond what is currently possible?
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Author: George Spellwin